US5443458A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Multilayered biodegradable stent and method of manufacture
Assignee: Abbott Cardiovascular Systems Inc
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Filing: 1993-12-03
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Granted: 1995-08-22
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Expires: 2013-12-03
Abstract
Abstract A stent of multilayered laminated construction wherein one layer addresses the structural requirements of the stent and additional layers release drugs at predictable rates. Both the structural layer as well as the drug releasing layers are eventually completely resorbed by the body.
Inventors
- 👤 Robert P. Eury
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:58
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/92; A61L; A61L31/00; A61L31/04; A61L31/06; A61L31/08; A61L31/10; A61L31/14; A61L31/148; A61L31/16; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2002/072; A61F2210/00; A61F2210/0004; A61F2210/0076; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/40; A61L2300/416; A61L2300/42; A61L2300/45; A61L2300/60; A61L2300/602; A61L2300/606; A61L2300/608; A61L2420/00; A61L2420/08
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
99 words
A method of fabricating a biodegradable, drug releasing stent for implantation within a lumen, comprising the steps of: forming a first layer of biodegradable material having physical properties necessary to enable a stent to maintain patency of said lumen; forming a second layer of biodegradable material which releases a selected drug upon exposure to an environment such as is encountered within said lumen; and superposing said second layer on said first layer to provide a laminated structure that is biodegradable, drug releasing and has the physical properties necessary for said stent to perform its structural function within said lumen.
Claim 2
Independent Claim
99 words
A method of fabricating a biodegradable, drug releasing stent for implantation within a lumen, comprising the steps of: forming a first layer of biodegradable material having physical properties necessary to enable a stent to maintain patency of said lumen; forming a second layer of biodegradable material which releases a selected drug upon exposure to an environment such as is encountered within said lumen; and superposing said second layer on said first layer to provide a laminated structure that is biodegradable, drug releasing and has the physical properties necessary for said stent to perform its structural function within said lumen.
Claim 3
Dependent Claim
43 words
The method of claim 1 further comprising the steps of: forming a third layer of biodegradable material which releases a selected drug upon exposure to an environment such as is encountered within said lumen; and superposing said third layer to said first layer.
Claim 4
Dependent Claim
22 words
The method of claim 2, wherein said second and third layers are joined to said first layer with the application of heat.
Claim 5
Dependent Claim
22 words
The method of claim 2 wherein said second and third layers are joined to said first layer with the use of solvents.
Claim 6
Dependent Claim
19 words
The method of claim 1, wherein said first layer is formed by extrusion and orientation of a polymeric material.
Claim 7
Dependent Claim
12 words
The method of claim 5, wherein said polymeric material comprises poly-L-lactic acid.
Claim 8
Dependent Claim
12 words
The method of claim 5 wherein said polymeric material comprises polyglycolic acid.
Claim 9
Dependent Claim
19 words
The method of claim 1, wherein said second layer comprises a mixture of said drug and a polymeric material.
Claim 10
Dependent Claim
12 words
The method of claim 8 wherein said polymeric material comprises poly-DL-lactic acid.
Claim 11
Dependent Claim
12 words
The method of claim 8 wherein a polymeric material comprises a polycaprolactone.
Claim 12
Dependent Claim
20 words
The method of claim 1, wherein said second layer is joined to said first layer with the application of heat.
Claim 13
Dependent Claim
20 words
The method of claim 1, wherein said second layer is joined to said first layer with the use of solvents.
Claim 14
Dependent Claim
109 words
An expandable stent for implantation in a vessel, comprising: a first layer formed of a first resorbable material selected to impart structural rigidity to said stent for maintaining patency of the vessel; and second layer formed of a second resorbable material, superposed on and laminated to said first layer and selected to release a therapeutic drug at a predictable rate upon implantation; said first layer and said second layer rolled up to form a cylinder for delivery to the site at which the stent is to be implanted; and said stent providing a desired degree of structural support to said vessel, and releasing said drug at said predictable rate.
Claim 15
Dependent Claim
109 words
An expandable stent for implantation in a vessel, comprising: a first layer formed of a first resorbable material selected to impart structural rigidity to said stent for maintaining patency of the vessel; and second layer formed of a second resorbable material, superposed on and laminated to said first layer and selected to release a therapeutic drug at a predictable rate upon implantation; said first layer and said second layer rolled up to form a cylinder for delivery to the site at which the stent is to be implanted; and said stent providing a desired degree of structural support to said vessel, and releasing said drug at said predictable rate.
Claim 16
Dependent Claim
23 words
The stent of claim 13, wherein said material of said first layer further is selected to impart high tensile strength to said stent.
Claim 17
Dependent Claim
12 words
The stent of claim 13, wherein said first layer comprises poly-L-lactic acid.
Claim 18
Dependent Claim
12 words
The stent of claim 13, wherein said first layer comprises polyglycolic acid.
Claim 19
Dependent Claim
12 words
The stent of claim 13, wherein said second layer comprises poly-DL-lactic acid.
Claim 20
Dependent Claim
11 words
The stent of claim 13, wherein said second layer comprises polycaprolactone.
Claim 21
Dependent Claim
29 words
The stent of claim 13, wherein said stent is implantable in a lumen upstream from a cancerous growth and said second layer is selected to release a chemotherapeutic drug.
Claim 22
Dependent Claim
14 words
The stent of claim 13, wherein said second layer is selected to release heparin.
Claim 23
Dependent Claim
23 words
The stent of claim 20, wherein said second layer is selected to release angiopeptin, and said third layer is selected to release heparin.
Claim 24
Dependent Claim
61 words
The stent of claim 13, wherein a third layer of resorbable material is superposed on and laminated to said first layer and selected to release a therapeutic drug at a predictable rate therefrom, whereby upon implantation, said stent initially provides a desired degree of structural support to said vessel, releases said drugs at the predictable rates, and eventually is completely resorbed.
Claim 25
Dependent Claim
18 words
The stent of claim 22, wherein the drugs released by said second and said third layer are identical.
Claim 26
Dependent Claim
18 words
The stent of claim 22, wherein the drugs released by said second and said third layer are different.
Claim 27
Dependent Claim
63 words
The stent of claim 24, wherein said stent is implantable within a coronary artery, said second layer is superposed on and laminated to the outer side of said stent's first layer and releases a drug that addresses restenosis, and said third layer is superposed on and laminated to the inner side of said stent's first layer and releases a drug that addresses thrombosis.
References Cited (Backward Citations)
US4321711A
Cited
US4850999A
Cited
US4902289A
Cited
US4743252A
Cited
US5028597A
Cited
US5306286A
Cited
WO1989003233A1
Cited
WO1990001969A1
Cited
EP0364787B1
Cited
WO1990004982A1
Cited
WO1990006094A1
Cited
US5100429A
Cited
US5084065A
Cited
WO1991017744A1
Cited
WO1991017789A1
Cited
WO1992010218A1
Cited
EP0493788A1
Cited
WO1993006792A1
Cited
US5234457A
Cited
US5282860A
Cited
US5306294A
Cited
US5342348A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-08-21 | 1999-02-20 | 1999-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-08-21 | 2003-02-20 | 2003-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-08-21 | 2007-02-20 | 2007-08-22 | $7700.00 | Window Closed / Lapsed |