Patent US3568760A successfully refreshed from Google Patents.
US5874537A
Expired / Lapsed
US
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Method for sealing tissues with collagen-based sealants
Assignee: CR Bard Inc
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Filing: 1996-03-05
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Granted: 1999-02-23
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Expires: 2016-03-05
Abstract
Abstract Collagen-based compositions as adhesives and sealants for medical use and preparation thereof are described. Prior to polymerization, soluble or partially fibrillar collagen monomers in solution are chemically modified with an acylating agent, sulfonating agent or a combination of the foregoing. The collagen compositions prepared accordingly can be used as medical adhesives for bonding soft tissues or be made in to a sealant film for a variety of medical uses such as wound closures and tendon wraps for preventing adhesion formation following surgery.
Inventors
- 👤 Charles D. Kelman
- 👤 Dale P. DeVore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:23
CPC Classifications
C; C08; C08H; C08H1/00; C08H1/06; A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F9/00; A61F9/007; A61F9/0079; A61F9/008; A61F9/00802; A61F9/00817; A61F9/00819
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
59 words
A method of sealing an opening in a tissue comprising: (1) applying to said tissue a polymerizable collagen composition to cover said opening in said tissue; (2) exposing said polymerizable collagen composition to an initiator so as to initiate polymerization of said polymerizable collagen composition, whereby said exposed polymerizable composition forms a seal over the opening in said tissue.
Claim 2
Independent Claim
59 words
A method of sealing an opening in a tissue comprising: (1) applying to said tissue a polymerizable collagen composition to cover said opening in said tissue; (2) exposing said polymerizable collagen composition to an initiator so as to initiate polymerization of said polymerizable collagen composition, whereby said exposed polymerizable composition forms a seal over the opening in said tissue.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said opening is an incision.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein said opening is a wound.
Claim 5
Dependent Claim
36 words
The method according to claim 3, wherein said polymerizable collagen composition comprises a collagen selected from the group consisting of purified Type I collagen, purified Type III collagen, purified Type IV collagen and collagen rich tissue.
Claim 6
Dependent Claim
19 words
The method according to claim 4, wherein the Type I collagen is derived from human tissue or animal tissue.
Claim 7
Dependent Claim
15 words
The method according to claim 5, wherein the Type I collagen comprises autogenic human tissue.
Claim 8
Dependent Claim
29 words
The method of claim 1 wherein the polymerizable collagen composition is formed by a reaction between a collagen and at least one of an acylating agent and sulfonating agent.
Claim 9
Dependent Claim
29 words
The method according to claim 7, wherein the sulfonating agent is selected from the group consisting of anthraquinone-1,5-disulfonic acid, 2-(chlorosulfonyl)-anthraquinone, 2-acrylamido-2-methyl-1-propane sulfonic acid, 8-hydroxyquinoline-5-sulfonic acid, and beta-styrene sulfonyl chloride.
Claim 10
Dependent Claim
15 words
The method according to claim 8, wherein the sulfonating agent is 2-(chlorosulfonyl)-anthraquinone or anthraquinone-1,5-disulfonic acid.
Claim 11
Dependent Claim
50 words
The method according to claim 7, wherein the acylating agent is selected from the group consisting of glutaric anhydride, succinic anhydride, lauric anhydride, diglycolic anhydride, methyl succinic anhydride, methyl glutaric anhydride, dimethyl glutaric anhydride, exo-3,6-epoxy-1,2,3,4-tetrahydrophthalic anhydride, 3,6-endoxo-3-methyl hexahydrophthalic anhydride, endo-3,6-dimethyl-3,6-endoxohexahydrophthalic anhydride, methacrylic anhydride, succinyl chloride, glutaryl chloride, and lauryl chloride.
Claim 12
Dependent Claim
13 words
The method according to claim 10, wherein the acylating agent is glutaric anhydride.
Claim 13
Dependent Claim
13 words
The method according to claim 10, wherein the acylating agent is methacrylic anhydride.
Claim 14
Dependent Claim
13 words
The method according to claim 10, wherein the acylating agent is exo-3,6-epoxy-1,2,3,4-tetrahydrophthalic anhydride.
Claim 15
Dependent Claim
28 words
The method according to claim 1, wherein the initiator is UV irradiation, sodium persulfate, sodium thiosulfate, ferrous chloride tetrahydrate, sodium bisulfite, an oxidative enzyme, or a combination thereof.
Claim 16
Dependent Claim
11 words
The method according to claim 14, wherein UV irradiation is used.
Claim 17
Dependent Claim
11 words
The method according to claim 14, wherein sodium persulfate is used.
Claim 18
Dependent Claim
15 words
The method according to claim 14, wherein the oxidative enzyme is peroxidase or catechol oxidase.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2002-02-22 | 2002-08-24 | 2003-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-22 | 2006-08-24 | 2007-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-22 | 2010-08-24 | 2011-02-23 | $7700.00 | Window Closed / Lapsed |