US5356614A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process of preparing microparticulate collagen collagen-based products produced thereby and method of applying same
Assignee: Micro-Collagen Pharmaceutics Ltd
•
Filing: 1992-12-02
•
Granted: 1994-10-18
•
Expires: 2012-12-02
Abstract
Abstract There is disclosed a collagen preparation of improved adhesive properties and formed of microparticulate collagen of a particle size of from 0.5 to 2 μm, preferably 0.5 to 1.0 μm preferably submicrosized in a delivery system, such as an aerosol, and thus in sprayable form as a wound dressing alone, or with releasing drugs or other active agents. The microparticulate collagen is formed by ball milling collagen for a time sufficient to form the microparticulate collagen having a particle size of from 0.5 to 2 μm, preferably 0.5 to 1 μm.
Inventors
- 👤 Vinay K. Sharma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:09
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/42; A61K9/00; A61K9/70; A61K9/7015; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L26/0052; A61L26/0061; A61L26/0066; A61L26/0076; A61P; A61P17/00; A61P43/00; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/41; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/62; A61L2300/622
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
46 words
A process for particulating collagen, which comprises: a) introducing collagen with an inert media into a ball mixing zone; b) ball milling for a time sufficient to form microparticulate collagen having a particle size of from 0.1 to 5.0 μm; and c) recovering said microparticulate collagen.
Claim 2
Dependent Claim
46 words
A process for particulating collagen, which comprises: a) introducing collagen with an inert media into a ball mixing zone; b) ball milling for a time sufficient to form microparticulate collagen having a particle size of from 0.1 to 5.0 μm; and c) recovering said microparticulate collagen.
Claim 3
Dependent Claim
30 words
The process as defined in claim 1 wherein ball milling is effected for a time sufficient to produce submicroparticulate collagen of a particle size of from 0.5 to 2.0 μm.
Claim 4
Dependent Claim
17 words
The process as defined in claim 1 wherein said inert media is a low molecular weight alcohol.
Claim 5
Dependent Claim
21 words
The process as defined in claim 2 wherein collagen to inert liquid is in a ratio of from 1:5 to 1:50.
Claim 6
Dependent Claim
15 words
The process as defined in claim 3 wherein said ratio is preferably 1:10 to 1:15.
Claim 7
Dependent Claim
18 words
The process as defined in claim 1 wherein ball milling is effected for from 60 to 90 hours.
Claim 8
Dependent Claim
16 words
The process as defined in claim 6 wherein ball milling is effected for about 72 hours.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-17 | 1998-04-18 | 1998-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-17 | 2002-04-18 | 2002-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-17 | 2006-04-18 | 2006-10-18 | $7700.00 | Window Closed / Lapsed |