US4453939A
Expired / Lapsed
US
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Composition for sealing and healing wounds
Assignee: HORMO-CHEMIE MUNCHEN GmbH
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Filing: 1982-02-11
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Granted: 1984-06-12
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Expires: 2002-02-11
Abstract
Abstract A composition and its use for sealing and healing of wounds, comprising a collagen carrier which is coated on one face or all faces with a mixture of (1) a fibrinogen component which contains fibrinogen, factor XIII-containing fibrinogen or a mixture thereof, and (2) a thrombin component which contains thrombin, a substance which liberates thrombin in the presence of body fluid or a mixture of such substances. The mixture of (1) and (2) optionally may additionally contain conventional additives, such as calcium ions, protease inhibitors, heparin antagonists, substances which promote the infiltration and growth of fibroblasts, such as fibronectin, as well as antibiotics and/or bactericides.
Inventors
- 👤 Eberhard Zimmerman
- 👤 Ulrich Schiele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:55
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L24/106; A61L2400/00; A61L2400/04; Y; Y10; Y10S; Y10S602/00; Y10S602/90
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
114 words
A process for the preparation of a composition for sealing and healing wounds which comprises adding a mixture of (1) a fibrinogen component containing fibrinogen, factor XIII-containing fibrinogen or a mixture thereof, and (2) a thrombin component containing thrombin, a substance which liberates thrombin in the presence of body fluid, or a mixture of such substances, to an organic solvent, in the absence of water, homogenizing the resulting slurry to form a homogeneous suspension of the mixture in the solvent, applying the said suspenion to one or more surfaces of a collagen carrier and evaporating the organic solvent, whereby particles of the said mixture remain adhering to the surface or surfaces of the collagen.
Claim 2
Dependent Claim
114 words
A process for the preparation of a composition for sealing and healing wounds which comprises adding a mixture of (1) a fibrinogen component containing fibrinogen, factor XIII-containing fibrinogen or a mixture thereof, and (2) a thrombin component containing thrombin, a substance which liberates thrombin in the presence of body fluid, or a mixture of such substances, to an organic solvent, in the absence of water, homogenizing the resulting slurry to form a homogeneous suspension of the mixture in the solvent, applying the said suspenion to one or more surfaces of a collagen carrier and evaporating the organic solvent, whereby particles of the said mixture remain adhering to the surface or surfaces of the collagen.
Claim 3
Dependent Claim
45 words
A process according to claim 1, in which the mixture of (1) and (2) also includes one or more conventional additives selected from the group consisting of calcium ions, protease inhibitors, heparin antagonists, substances which promote the infiltration and growth of fibroblasts and anti-infection medicaments.
Claim 4
Dependent Claim
37 words
A process according to claim 1, in which the organic solvent is a straight-chain or branched C 1 -C 5 alkanol, an aliphatic halogenated hydrocarbon, an ester, a nitrile, a ketone or an aliphatic or cycloaliphatic ether.
Claim 5
Dependent Claim
70 words
A composition for sealing and healing wounds prepared by the process according to claim 1 and comprising a collagen carrier which is coated on one face or all faces with a mixture of (1) a fibrinogen component containing fibrinogen, factor XIII-containing fibrinogen or a mixture thereof, and (2) a thrombin component, containing thrombin, a substance which liberates thrombin in the presence of body fluid, or a mixture of such substances.
Claim 6
Dependent Claim
45 words
A composition according to claim 4, in which the mixture of (1) and (2) also includes one or more conventional additives selected from the group consisting of calcium ions, protease inhibitors, heparin antagonists, substances which promote the infiltration and growth of fibroblasts and anti-infection medicaments.
Claim 7
Dependent Claim
16 words
A composition according to claim 4 or 5, wherein the collagen carrier is a collagen foam.
Claim 8
Dependent Claim
22 words
A composition according to claim 4 or 5, wherein the amount of the fibrinogen component is 0.05 to 20 mg/cm 2 .
Claim 9
Dependent Claim
20 words
A composition according to claim 7, wherein the amount of the fibrinogen component is 0.5 to 5 mg/cm 2 .
Claim 10
Dependent Claim
23 words
A composition according to claim 4 or 5, wherein the amount of the thrombin component is 1 μg to 5 mg/cm 2 .
Claim 11
Dependent Claim
21 words
A composition according to claim 9, wherein the amount of the thrombin component is 50 μg to 1 mg/cm 2 .
Claim 12
Dependent Claim
20 words
A composition according to claim 5, wherein the conventional additive which promotes the infiltration and growth of fibroblasts is fibronectin.
Claim 13
Dependent Claim
78 words
A method for the treatment of wounds, which comprises administering to the wound a composition prepared by the process according to claim 10 and comprising a collagen carrier which is coated on one face or all faces with a mixture of (1) a fibrinogen component containing fibrinogen, factor XIII-containing fibrinogen or a mixture thereof, and (2) a thrombin component, containing thrombin, a substance which liberates thrombin in the presence of body fluid, or a mixture of such substances.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |