US5173295A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor
Assignee: Advance Biofactures Corp
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Filing: 1990-10-05
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Granted: 1992-12-22
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Expires: 2010-10-05
Abstract
Abstract The regeneration of injured nerves is enhanced by supplying collagenase to the zone of injury of the nerve. Growth of nerve sprouts over the zone of injury is aided by the presence of effective amounts of collagenase during the regeneration process. If the nerve has been severed, collagenase is supplied to the ends of the proximal and distal stumps. A nerve graft may be interposed between the stumps. Natural fibrin has been used as glue to join nerve stumps, and collagenase is effective when used in admixture with fibrin.
Inventors
- 👤 Peter Wehling
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:28
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/4886; A61L24/001; A61L24/0015; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/254
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
29 words
A method of enhancing the regeneration of injured nerves which comprises administering an effective amount of collagenase to the zone of injury of the nerve during the regeneration process.
Claim 2
Independent Claim
29 words
A method of enhancing the regeneration of injured nerves which comprises administering an effective amount of collagenase to the zone of injury of the nerve during the regeneration process.
Claim 3
Dependent Claim
25 words
A method according to claim 1 wherein the nerve has been severed and collagenase is administered to the ends of the proximal and distal stumps.
Claim 4
Dependent Claim
17 words
A method according to claim 2 wherein fibrin containing collagenase is used as adhesive for the stumps.
Claim 5
Dependent Claim
11 words
A method according to claim 3 wherein the ends are sutured.
Claim 6
Dependent Claim
18 words
A method according to claim 4 wherein the sutured region is coated with a fibrin and collagenase mixture.
Claim 7
Dependent Claim
14 words
A method according to claim 1 wherein injury has resulted in neuroma in continuity.
Claim 8
Dependent Claim
19 words
A method according to claim 1 wherein the stumps of individual served fascicles of fascicle groups are separately co-apted.
Claim 9
Dependent Claim
15 words
A method according to claim 2 wherein a nerve graft is interposed between the stumps.
Claim 10
Dependent Claim
12 words
A method according to claim 8 wherein interfascicular nerve grafts are employed.
Claim 11
Dependent Claim
24 words
A method according to claim 1 wherein collagenase is supplied in a pharmaceutically acceptable medium containing about 200 to 2,500 ABC units of collagenase/ml.
Claim 12
Dependent Claim
12 words
A method according to claim 10 wherein the medium comprises normal saline.
Claim 13
Dependent Claim
24 words
A method according to claim 1 wherein collagenase is supplied in a pharmaceutically acceptable medium containing about 500 to 1,000 ABC units of collagenase/ml.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-22 | 1996-06-22 | 1996-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-22 | 2000-06-22 | 2000-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-22 | 2004-06-22 | 2004-12-22 | $7700.00 | Window Closed / Lapsed |