Patent US2258462A successfully refreshed from Google Patents.
Patent US5827222A successfully refreshed from Google Patents.
US5827222A
Expired / Lapsed
US
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Method of treating at least one of brain and associated nervous tissue injury
Assignee: Organ Recovery Systems Inc
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Filing: 1995-06-07
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Granted: 1998-10-27
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Expires: 2015-06-07
Abstract
Abstract The invention discloses a method for treating brain and associated nervous tissue injury. The invention also discloses a method for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. Also disclosed is a method for organ preservation which employs body cavity perfusion. The methods include the introduction of temperature-controlled solutions to slow the metabolism of the brain, associated nervous tissue or organ(s) to inhibit degeneration thereof. A device which performs these methods is also disclosed. The device includes a fluid reservoir, an oxygen source, a heat exchanger and removable catheter lines.
Inventors
- 👤 Ronald M. Klatz
- 👤 Robert M. Goldman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:39
CPC Classifications
A; A61; A61H; A61H31/00; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/142; A01N1/143; A61B; A61B16/00; A61M; A61M16/00; A61M16/0054; A61M16/021; A61M16/022; A61M5/00; A61M5/14; A61M60/00; A61M60/10; A61M60/122; A61M60/126; A61M60/13; A61M60/20; A61M60/295; A61M60/30; A61M60/36; A61M60/38; A61M60/40; A61M60/497; A61B17/00; A61B2017/00969; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2210/00; A61M2210/06; A61M2210/0693; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
108 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. establishing an artificial circulation in the circulatory system of a patient; b. driving the brain of the patient into a comatose state; c. oxygenating the brain by introducing oxygen carrying agents into the artificial circulation; and d. lowering the brain temperature by introducing cooled fluid to at least one of the brain and associated nervous tissue, said cooled fluid being at a temperature below body temperature; whereby metabolic rates of at least one of the brain and associated nervous tissue are slowed and said patient remains substantially neurologically intact.
Claim 2
Independent Claim
108 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. establishing an artificial circulation in the circulatory system of a patient; b. driving the brain of the patient into a comatose state; c. oxygenating the brain by introducing oxygen carrying agents into the artificial circulation; and d. lowering the brain temperature by introducing cooled fluid to at least one of the brain and associated nervous tissue, said cooled fluid being at a temperature below body temperature; whereby metabolic rates of at least one of the brain and associated nervous tissue are slowed and said patient remains substantially neurologically intact.
Claim 3
Dependent Claim
32 words
The method of claim 1, wherein said method comprises shunting all effective cardiac output away from the lower extremities and lower abdomen to the internal organs, including the heart and the brain.
Claim 4
Dependent Claim
24 words
The method of claim 1, wherein the brain of said patient is driven into a comatose state by introducing barbiturates into said artificial circulation.
Claim 5
Dependent Claim
12 words
The method of claim 1, wherein said oxygen carrying agents include perfluorocarbons.
Claim 6
Dependent Claim
15 words
The method of claim 1, wherein said fluid is cooled to approximately 40 Degrees Fahrenheit.
Claim 7
Dependent Claim
21 words
The method of claim 1, wherein said step of establishing an artificial circulation comprises catheterizing a blood vessel of the patient.
Claim 8
Dependent Claim
69 words
The method of claim 1, wherein said step of establishing an artificial circulation includes inserting a balloon catheter with a valve at a distal point on said catheter into a blood vessel of said patient and inflating said balloon of said catheter once said catheter is completely inserted into a blood vessel to block the blood vessel, thereby limiting reverse blood flow through said blood vessel toward the heart.
Claim 9
Dependent Claim
37 words
The method of claim 1, wherein said method further comprises the step of introducing nervous tissue protecting agents and damage reversing agents to at least one of the brain and associated nervous tissue through said artificial circulation.
Claim 10
Dependent Claim
24 words
The method of claim 8, wherein said protecting and damage reversing agents include at least one member selected from the group consisting of Lazaroids.
Claim 11
Dependent Claim
42 words
The method of claim 1, further comprising a step of introducing a solution comprising a free radical scavenger into the circulatory system of the patient, in an amount effective to prevent an oxidative burst of free radicals, prior to the oxygenating step.
Claim 12
Dependent Claim
30 words
The method of claim 10, wherein the introduction of a solution comprising a free radical scavenger is done prior to driving the brain of the patient into a comatose state.
Claim 13
Dependent Claim
26 words
The method of claim 1, wherein said method further comprises the step of inhibiting free radical damage by introducing free radical scavengers into said artificial circulation.
Claim 14
Dependent Claim
12 words
The method of claim 12, wherein said free radical scavengers include antioxidants.
Claim 15
Dependent Claim
34 words
The method of claim 13, wherein said antioxidants include at least one member selected from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 16
Dependent Claim
15 words
The method of claim 1, wherein said introducing is through at least one blood vessel.
Claim 17
Dependent Claim
18 words
The method of claim 15, wherein said at least one blood vessel is at least one carotid artery.
Claim 18
Dependent Claim
60 words
The method of claim 16, wherein said artificial circulation establishing step includes using a balloon catheter with a valve at a distal point on said catheter, and inflating said balloon of said catheter once said catheter is completely inserted into said at least one carotid artery, limiting reverse blood flow through said at least one carotid artery toward the heart.
Claim 19
Independent Claim
73 words
A method of treating at least one of brain and associated nervous tissue injury, comprising: a. providing a solution including barbiturates, free radical scavengers and oxygen carrying agents; b. oxygenating said solution; c. cooling said solution to a temperature below body temperature; d. introducing said solution into a patient at an introduction point within said patient's body; whereby metabolic rates of at least one of the brain and associated nervous tissue are slowed.
Claim 20
Independent Claim
73 words
A method of treating at least one of brain and associated nervous tissue injury, comprising: a. providing a solution including barbiturates, free radical scavengers and oxygen carrying agents; b. oxygenating said solution; c. cooling said solution to a temperature below body temperature; d. introducing said solution into a patient at an introduction point within said patient's body; whereby metabolic rates of at least one of the brain and associated nervous tissue are slowed.
Claim 21
Dependent Claim
32 words
The method of claim 18, wherein said method comprises shunting all effective cardiac output away from the lower extremities and lower abdomen to the internal organs, including the heart and the brain.
Claim 22
Dependent Claim
12 words
The method of claim 18, wherein said oxygen carrying agents include perfluorocarbons.
Claim 23
Dependent Claim
16 words
The method of claim 18, wherein said introduction point is through at least one blood vessel.
Claim 24
Dependent Claim
34 words
The method of claim 18, wherein the introducing step includes the step of employing a balloon catheter with a distal end valve, said catheter limiting reverse blood flow through blood vessels toward the heart.
Claim 25
Dependent Claim
39 words
The method of claim 18, wherein said at least one of said radical scavenger includes at least one member from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 26
Dependent Claim
15 words
The method of claim 18, wherein said fluid is cooled to approximately 40 Degrees Fahrenheit.
Claim 27
Dependent Claim
53 words
The method of claim 18, wherein the solution including barbiturates, free radical scavengers and oxygen carrying agents is divided into two portions, and a first portion of said solution is introduced into the patient prior to the oxygenating and cooling steps, in an amount effective to prevent an oxidative burst of free radicals.
Claim 28
Dependent Claim
18 words
The method of claim 18, wherein said solution additionally comprises nervous tissue protecting agents and damage reversing agents.
Claim 29
Dependent Claim
13 words
The method of claim 26, wherein said nervous tissue protecting agents include Lazaroids.
Claim 30
Independent Claim
130 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. providing a portable brain resuscitation device including: i. at least one fluid reservoir containing brain resuscitation solution; ii. an oxygenator in fluid communication with said at least one reservoir; iii. a temperature controller for said resuscitation solution, said temperature controller being in operative communication with said at lease one reservoir; iv. a conduit for moving said solution from said device to a patient, said conduit being attached to said portable brain resuscitation device; b. cooling said brain resuscitation solution below body temperature; and c. introducing said cooled fluid into the circulatory system of said patient, to slow the metabolic rate of at least one of the brain and associated nervous tissue.
Claim 31
Independent Claim
130 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. providing a portable brain resuscitation device including: i. at least one fluid reservoir containing brain resuscitation solution; ii. an oxygenator in fluid communication with said at least one reservoir; iii. a temperature controller for said resuscitation solution, said temperature controller being in operative communication with said at lease one reservoir; iv. a conduit for moving said solution from said device to a patient, said conduit being attached to said portable brain resuscitation device; b. cooling said brain resuscitation solution below body temperature; and c. introducing said cooled fluid into the circulatory system of said patient, to slow the metabolic rate of at least one of the brain and associated nervous tissue.
Claim 32
Dependent Claim
25 words
The method of claim 28, wherein said conduit is attached to said portable brain resuscitation device at a point in communication with said temperature controller.
Claim 33
Dependent Claim
32 words
The method of claim 28, wherein said method comprises shunting all effective cardiac output away from the lower extremities and lower abdomen to the internal organs, including the heart and the brain.
Claim 34
Dependent Claim
13 words
The method of claim 28, wherein said temperature controller includes a heat exchanger.
Claim 35
Dependent Claim
33 words
The method of claim 28, wherein a balloon catheter with a valve at its distal end is attached to the conduit, and the introducing step includes flowing the solution through the balloon catheter.
Claim 36
Dependent Claim
17 words
The method of claim 28, wherein a point of said introducing is at least one blood vessel.
Claim 37
Dependent Claim
44 words
The method of claim 28, wherein the brain resuscitation solution comprises a free readical scavenger and a first portion of said solution is introduced into the patient prior to the cooling step, in an amount effective to prevent an oxidative burst of free radicals.
Claim 38
Dependent Claim
15 words
The method of claim 28, wherein said solution is cooled to approximately 40 Degrees Fahrenheit.
Claim 39
Dependent Claim
14 words
The method of claim 35, wherein said brain resuscitation solution comprises: free radical scavengers.
Claim 40
Dependent Claim
12 words
The method of claim 35, wherein said free radical scavengers include antioxidants.
Claim 41
Dependent Claim
33 words
The method of claim 36, wherein said antioxidants include at least one member from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 42
Dependent Claim
32 words
The method of claim 35, wherein said brain resuscitation solution comprises: oxygen carrying agents in an amount effective to transport oxygen to at least one of said brain and associated nervous tissues.
Claim 43
Dependent Claim
28 words
The method of claim 39, wherein said brain resuscitation solution additionally comprises: barbiturates in an amount effective to induce a coma in the brain and associated nervous tissue.
Claim 44
Dependent Claim
12 words
The method of claim 39, wherein said oxygen carrying agents include perfluorocarbons.
Claim 45
Dependent Claim
20 words
The method of claim 39, wherein said brain resuscitation solution additionally comprises: an effective amount of nervous tissue protecting agents.
Claim 46
Dependent Claim
13 words
The method of claim 35, wherein said nervous tissue protecting agents include Lazaroids.
Claim 47
Dependent Claim
21 words
The method of claim 39, wherein said brain resuscitation solution additionally comprises: an effective amount of nervous tissue damage reversing agents.
Claim 48
Dependent Claim
14 words
The method of claim 44, wherein said nervous tissue damage reversing agents include Lazaroids.
Claim 49
Independent Claim
127 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. establishing an artificial circulation in the cardiovascular system of a patient; b. utilizing a control system to cool and oxygenate a fluid; c. oxygenating and lowering the metabolism of the brain by introducing the oxygenated, cooled fluid to at least one of the brain and associated nervous tissue via the artificial circulation, said cooled fluid being at a temperature below body temperature; and d. introducing a solution comprising a free radical scavenger into the circulatory system of the patient, in an amount effective to prevent an oxidative burst of free radicals, prior to the step of oxygenating and lowering the metabolism whereby said patient remains substantially neurologically intact.
Claim 50
Independent Claim
127 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. establishing an artificial circulation in the cardiovascular system of a patient; b. utilizing a control system to cool and oxygenate a fluid; c. oxygenating and lowering the metabolism of the brain by introducing the oxygenated, cooled fluid to at least one of the brain and associated nervous tissue via the artificial circulation, said cooled fluid being at a temperature below body temperature; and d. introducing a solution comprising a free radical scavenger into the circulatory system of the patient, in an amount effective to prevent an oxidative burst of free radicals, prior to the step of oxygenating and lowering the metabolism whereby said patient remains substantially neurologically intact.
Claim 51
Independent Claim
145 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. establishing an artificial circulation in the cardiovascular system of a patient; b. utilizing a control system to cool and oxygenate a fluid; c. oxygenating and lowering the metabolism of the brain by introducing the oxygenated, cooled fluid to at least one of the brain and associated nervous tissue via the artificial circulation, said cooled fluid being at a temperature below body temperature; and d. prior to introducing the oxygenated, cooled fluid to the at least one of the brain and associated nervous tissue via the artificial circulation, introducing an unoxygenated, uncooled fluid to the at least one of the brain and associated nervous tissue via the artificial circulation to prevent an oxidative burst of free radicals into the patient whereby said patient remains substantially neurologically intact.
Claim 52
Independent Claim
145 words
A method of treating at least one of brain and associated nervous tissue injury, comprising the steps of: a. establishing an artificial circulation in the cardiovascular system of a patient; b. utilizing a control system to cool and oxygenate a fluid; c. oxygenating and lowering the metabolism of the brain by introducing the oxygenated, cooled fluid to at least one of the brain and associated nervous tissue via the artificial circulation, said cooled fluid being at a temperature below body temperature; and d. prior to introducing the oxygenated, cooled fluid to the at least one of the brain and associated nervous tissue via the artificial circulation, introducing an unoxygenated, uncooled fluid to the at least one of the brain and associated nervous tissue via the artificial circulation to prevent an oxidative burst of free radicals into the patient whereby said patient remains substantially neurologically intact.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-10-26 | 2002-04-27 | 2002-10-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-10-26 | 2006-04-27 | 2006-10-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-10-26 | 2010-04-27 | 2010-10-27 | $7700.00 | Window Closed / Lapsed |