US4451251A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
Assignee: Thomas Jefferson University
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Filing: 1982-09-30
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Granted: 1984-05-29
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Expires: 2002-09-30
Abstract
Abstract A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Inventors
- 👤 Jewell L. Osterholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:25
CPC Classifications
A; A61; A61M; A61M3/00; A61M3/02; A61M3/0204; A61M3/0212; A61M2202/00; A61M2202/04; A61M2202/0464; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653; A61M2210/00; A61M2210/06; A61M2210/0693
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
116 words
An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said reservoir for oxygenating said emulsion, to produce an oxygenated liquid; (c) cerebrospinal injection means disposed in fluid communication with said oxygenator means for injecting said oxygenated liquid into an extravascular cerebrospinal body pathway; (d) cerebrospinal withdrawal means for withdrawing liquid from said extravascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said pathway; and (e) monitoring means in communication with said pathway for monitoring a physical/chemical characteristic of said withdrawn liquid.
Claim 2
Independent Claim
116 words
An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said reservoir for oxygenating said emulsion, to produce an oxygenated liquid; (c) cerebrospinal injection means disposed in fluid communication with said oxygenator means for injecting said oxygenated liquid into an extravascular cerebrospinal body pathway; (d) cerebrospinal withdrawal means for withdrawing liquid from said extravascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said pathway; and (e) monitoring means in communication with said pathway for monitoring a physical/chemical characteristic of said withdrawn liquid.
Claim 3
Dependent Claim
18 words
The invention of claim 1 wherein said withdrawal means comprises means for withdrawing liquid from a subarachnoid space.
Claim 4
Dependent Claim
19 words
The invention of claim 1 wherein said monitoring means comprises means for monitoring the temperature of said oxygenated liquid.
Claim 5
Dependent Claim
19 words
The invention of claim 1 wherein said monitoring means comprises means for monitoring the osmolarity of said oxygenated liquid.
Claim 6
Dependent Claim
21 words
The invention of claim 1 wherein said monitoring means comprises means for monitoring the concentrations of compounds comprising said withdrawn liquid.
Claim 7
Dependent Claim
23 words
The invention of claim 1 wherein said apparatus comprises output analysis means for monitoring at least one chemical characteristic of said withdrawn fluid.
Claim 8
Dependent Claim
37 words
The invention of claim 6 wherein said apparatus comprises means for comparing at least one of said output characteristics with corresponding characteristics of the oxygenated liquid, and for selectively altering said oxygenated liquid characteristics in response thereto.
Claim 9
Dependent Claim
47 words
The invention of claim 6 wherein said chemical compounds include at least one compound selected from the group consisting of: oxygen; carbon dioxide; sodium; calcium; lactic acid; carbohydrates; magnesium; potassium; fluoride; chloride; GABA; amino acids; catabolic enzyme; ammonia; neurotransmitter; metabolites; cellular organelles; myelin fragments; protein; polypeptides; lipids.
Claim 10
Dependent Claim
17 words
The invention of claim 6 wherein said monitoring means comprises means for monitoring the concentration of glucose.
Claim 11
Dependent Claim
17 words
The invention of claim 6 wherein said monitoring means comprises means for monitoring the concentration of dextrose.
Claim 12
Dependent Claim
17 words
The invention of claim 6 wherein said monitoring means comprises means for monitoring the concentration of LDH.
Claim 13
Dependent Claim
49 words
The invention of claim 7 wherein said injection means further comprises a cerebral catheter means for insertion into at least a brain ventricle for injecting a liquid therein, said cerebral catheter having an arrangement of outlet holes disposed as a series of slits radially spaced around the tip thereof.
Claim 14
Dependent Claim
42 words
The invention of claim 1 wherein said withdrawal means further comprises a catheter having a tip with multiple perforations disposed therein, said catheter further comprising means for attaching at least a portion thereof to tissue in the region of said subarachnoid space.
Claim 15
Dependent Claim
28 words
The invention of claim 13 wherein said means for attaching comprises a staple for attaching a noncollapsable portion of said catheter to a lumbar region of the skin.
Claim 16
Independent Claim
116 words
An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said reservoir for oxygenating said emulsion, to produce an oxygenated liquid; (c) cerebrospinal injection means disposed in fluid communication with said oxygenator means for injecting said oxygenated liquid into an extravascular cerebrospinal body pathway said injection means comprising a spinal catheter means for injecting said liquid into a spinal subarachnoid space; and (d) cerebrospinal withdrawal means for withdrawing liquid from said extravascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said pathway.
Claim 17
Independent Claim
116 words
An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said reservoir for oxygenating said emulsion, to produce an oxygenated liquid; (c) cerebrospinal injection means disposed in fluid communication with said oxygenator means for injecting said oxygenated liquid into an extravascular cerebrospinal body pathway said injection means comprising a spinal catheter means for injecting said liquid into a spinal subarachnoid space; and (d) cerebrospinal withdrawal means for withdrawing liquid from said extravascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said pathway.
Claim 18
Independent Claim
139 words
An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said reservoir for oxygenating said emulsion, to produce an oxygenated liquid; (c) cerebrospinal injection means disposed in fluid communication with said oxygenaor means for injecting said oxygenated liquid into an extravascular cerebrospinal body pathway said injection means comprising a cerebral catheter means for insertion into at least a brain ventricle for injection of liquid therein, and means for preventing the portion of the catheter located within said ventricle from damaging tissues surrounding said ventricle; and (d) cerebrospinal withdrawal means for withdrawing liquid from said extravascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said pathway.
Claim 19
Independent Claim
139 words
An apparatus for treating patients suspected of having hypoxic-ischemic central nervous system tissue, comprising: (a) a reservoir containing an oxygenatable fluorocarbon emulsion for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means disposed in fluid communication with said reservoir for oxygenating said emulsion, to produce an oxygenated liquid; (c) cerebrospinal injection means disposed in fluid communication with said oxygenaor means for injecting said oxygenated liquid into an extravascular cerebrospinal body pathway said injection means comprising a cerebral catheter means for insertion into at least a brain ventricle for injection of liquid therein, and means for preventing the portion of the catheter located within said ventricle from damaging tissues surrounding said ventricle; and (d) cerebrospinal withdrawal means for withdrawing liquid from said extravascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said pathway.
Claim 20
Dependent Claim
15 words
The invention of claim 16 wherein said means for preventing comprises an inflatable balloon tip.
Claim 21
Dependent Claim
30 words
The invention of claim 16 wherein said cerebral catheter means further comprises means for fixing at least a portion thereof with respect to the skull to thereby ensure catheter stability.
Claim 22
Dependent Claim
22 words
The invention of claim 1 wherein said monitoring means comprises means for monitoring at least the oxygen content of said oxygenated liquid.
Claim 23
Dependent Claim
21 words
The invention of claim 1 wherein said monitoring means comprises means for monitoring the CO 2 content of said oxygenated liquid.
Claim 24
Dependent Claim
22 words
The invention of claim 1 wherein said monitoring means comprises means for monitoring the pressure under which said oxygenated liquid is injected.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |