US5085630A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxygenated fluorocarbon nutrient solution
Assignee: Thomas Jefferson University
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Filing: 1990-05-21
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Granted: 1992-02-04
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Expires: 2010-05-21
Abstract
Abstract The invention provides novel improved oxygenated fluorocarbon nutrient solutions for treatment of hypoxic-ischemic neurologic tissue in mammals. The invention also provides methods of making such nutrient solution and methods of administering them.
Inventors
- 👤 Jewell L. Osterholm
- 👤 Glenn D. Frazer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:02
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K9/0029; A61M; A61M3/00; A61M3/02; A61M25/00; A61M25/01; A61M25/02; A61M2025/028; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
109 words
A method of treating hypoxic-ischemic neurologic tissue in mammals, comprising: (a) providing a physiologically acceptable synthetic oxygenatable fluid comprising bis-perflurobutyl ethylene with a synthetic electrolyte-containing cerebrospinal aqueous fluid to produce a physiologically acceptable emulsion; (b) oxygenating said oxygenatable fluid to produce an oxygenated fluid; (c) injecting a substantially continuous stream of said oxygenated fluid into the cerebrospinal fluid pathway, at a first injection point; (d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygenated fluid in the vicinity of said ischemic tissue, whereby ischemic neurologic tissue will be oxygenated and otherwise nourished by said fluid.
Claim 2
Independent Claim
109 words
A method of treating hypoxic-ischemic neurologic tissue in mammals, comprising: (a) providing a physiologically acceptable synthetic oxygenatable fluid comprising bis-perflurobutyl ethylene with a synthetic electrolyte-containing cerebrospinal aqueous fluid to produce a physiologically acceptable emulsion; (b) oxygenating said oxygenatable fluid to produce an oxygenated fluid; (c) injecting a substantially continuous stream of said oxygenated fluid into the cerebrospinal fluid pathway, at a first injection point; (d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygenated fluid in the vicinity of said ischemic tissue, whereby ischemic neurologic tissue will be oxygenated and otherwise nourished by said fluid.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein said first point is within a cerebral ventricle.
Claim 4
Dependent Claim
14 words
The method of claim 2 wherein said second point is within the lateral ventricle.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein said second point is within a subarachnoid space.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein said second point is within a cerebral cistern.
Claim 7
Dependent Claim
13 words
The method of claim 5 wherein said cerebral cistern is the cisterna magna.
Claim 8
Dependent Claim
14 words
The method of claim 4 wherein said subarachnoid space is a spinal subarachnoid space.
Claim 9
Dependent Claim
16 words
The method of claim 7 wherein said spinal subarachnoid space is a lumbar spinal subarachnoid space.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-02-03 | 1995-08-05 | 1996-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-02-03 | 1999-08-05 | 2000-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-02-03 | 2003-08-05 | 2004-02-04 | $7700.00 | Window Closed / Lapsed |