Abstract A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischmeic and other diseased neurologic tissue during treatment are provided.
A method of treating hypoxic-ischemic central nervous system tissue comprising: (a) providing a physiologically acceptable oxygenated fluorocarbon emulsion as treatment fluid; (b) establishing a circulation of said fluid through an oxygenator at a first preselected flow rate to oxygenate said fluid; (c) injecting said oxygenated fluid into the cerebrospinal pathway at a first injecting point and at a second preselected rate; (d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygented fluid in the vicinity of said hypoxic-ischemic tissue sufficient to support significant aerobic respiration of a portion of said tissue, whereby said portion of said tissue will be metabolically sustained during said treatment.
Claim 2
Independent Claim
118 words
A method of treating hypoxic-ischemic central nervous system tissue comprising: (a) providing a physiologically acceptable oxygenated fluorocarbon emulsion as treatment fluid; (b) establishing a circulation of said fluid through an oxygenator at a first preselected flow rate to oxygenate said fluid; (c) injecting said oxygenated fluid into the cerebrospinal pathway at a first injecting point and at a second preselected rate; (d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygented fluid in the vicinity of said hypoxic-ischemic tissue sufficient to support significant aerobic respiration of a portion of said tissue, whereby said portion of said tissue will be metabolically sustained during said treatment.
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein step (b) further comprises establishing a circulation of said fluid through a heat exchanger to adjust the temperature of said fluid prior to injection.
Claim 4
Dependent Claim
34 words
The invention of claim 2 wherein step (a) further comprises providing a reservoir means for containing said fluid and step (b) further comprises establishing a separate circulation through said heat exchanger to said reservoir.
Claim 5
Dependent Claim
17 words
The method of claim 3 wherein said separate circulation is established at a third preselected flow rate.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein step (c) further comprises first forcing said fluid through a filter.
Claim 7
Dependent Claim
12 words
The method of claim 5 wherein said filter is a bacterial filter.