US5149321A
Expired / Lapsed
US
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Brain resuscitation device and method for performing the same
Assignee: Organ Recovery Systems Inc
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Filing: 1990-10-10
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Granted: 1992-09-22
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Expires: 2010-10-10
Abstract
Abstract This invention discloses a method for resuscitating the brain as a result of ischemic and anoxic injuries whereby the patient survives neurologically intact. The method includes the steps of catheterizing the patient's circulatory system and introducing a temperature controlled solution to cool the brain to a coma and a state of hypothermic shock, further driving the brain into a submetabolic coma, oxygenating the brain and inhibiting free radical damage, and continuing additional efforts at life support. The temperature controlled brain resuscitation solution includes barbituates, perfluorocarbons, antioxidants, brain and neurologic tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines.
Inventors
- 👤 Ronald M. Klatz
- 👤 Robert M. Goldman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:09
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/14; A01N1/142; A01N1/143; A61; A61B; A61B16/00; A61M; A61M16/00; A61M16/0054; A61M16/021; A61M16/022; A61M5/00; A61M5/14; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/30; A61M60/36; A61M60/38; A61M60/50; A61M60/508; A61M60/538; A61M60/546; A61M60/554; A61M60/585; A61P; A61P25/00; A61P9/00; A61P9/10; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2210/00; A61M2210/06; A61M2210/0693
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
110 words
A method of treating anoxic or ischemic brain and associated nervous tissue injury comprising: a. establishing an artificial circulation in a patient's circulatory system by cathertizing said patient at an injection point; b. driving the brain into a comatose state by introducing barbiturates through said catheter; c. oxygenating the brain by introducing oxygen carrying agents through said catheter; d. lowering the brain temperature by introducing cooled fluid through said catheter, said cooled fluid being at a temperature below body temperature; e. inhibiting free radical damage by introducing free radical scavengers through said catheter; whereby metabolic rates of said tissues are slowed during treatment and said patient remains substantially neurologically intact.
Claim 2
Independent Claim
110 words
A method of treating anoxic or ischemic brain and associated nervous tissue injury comprising: a. establishing an artificial circulation in a patient's circulatory system by cathertizing said patient at an injection point; b. driving the brain into a comatose state by introducing barbiturates through said catheter; c. oxygenating the brain by introducing oxygen carrying agents through said catheter; d. lowering the brain temperature by introducing cooled fluid through said catheter, said cooled fluid being at a temperature below body temperature; e. inhibiting free radical damage by introducing free radical scavengers through said catheter; whereby metabolic rates of said tissues are slowed during treatment and said patient remains substantially neurologically intact.
Claim 3
Dependent Claim
42 words
The method of claim 1, wherein said method involves the initial step of applying means to said patient for shunting all effective cardiac output away from the lower extremities and lower abdomen to the internal organs including the heart and the brain.
Claim 4
Dependent Claim
25 words
The method of claim 1, wherein said method further involves the step of introducing nervous tissue protecting agents and damage reversing agents through said catheter.
Claim 5
Dependent Claim
15 words
The method of claim 1, wherein said injection point is at least one blood vessel.
Claim 6
Dependent Claim
15 words
The method of claim 4, wherein said blood vessel is at least one carotid artery.
Claim 7
Dependent Claim
59 words
The method of claim 5, wherein said artificial circulation establishing step further includes using a balloon catheter with a valve at a distal point on said catheter, and inflating said balloon once said catheter is completely inserted into said external carotid artery to block said external carotid artery, limiting reverse blood flow through said blood vessel toward the heart.
Claim 8
Dependent Claim
12 words
The method of claim 1, wherein said oxygen carrying agents include perfluorocarbons.
Claim 9
Dependent Claim
15 words
The method of claim 1, wherein said fluid is cooled to approximately 40 degrees Fahrenheit.
Claim 10
Dependent Claim
12 words
The method of claim 1, wherein said free radical scavengers include antioxidants.
Claim 11
Dependent Claim
24 words
The method of claim 9, wherein said antioxidants comprise: Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 12
Dependent Claim
13 words
The method of claim 3, wherein said protecting and reversing agents include Lazaroids.
Claim 13
Independent Claim
68 words
A method of treating anoxic and/or ischemic brain and associated nervous tissue injury comprising: a. providing a solution including barbiturates, free radical scavengers and oxygen carrying agents; b. oxygenating said solution; c. cooling said solution to a temperature substantially below body temperature; d. introducing said solution into a patient at an injection point within said patient's body; whereby metabolic rates of said nervous tissues are slowed during treatment.
Claim 14
Independent Claim
68 words
A method of treating anoxic and/or ischemic brain and associated nervous tissue injury comprising: a. providing a solution including barbiturates, free radical scavengers and oxygen carrying agents; b. oxygenating said solution; c. cooling said solution to a temperature substantially below body temperature; d. introducing said solution into a patient at an injection point within said patient's body; whereby metabolic rates of said nervous tissues are slowed during treatment.
Claim 15
Dependent Claim
42 words
The method of claim 12 wherein said method involves the initial step of applying means to said patient for shunting all effective cardiac output away from the lower extremities and lower abdomen to the internal organs including the heart and the brain.
Claim 16
Dependent Claim
24 words
The method of claim 12, wherein injection step further includes providing said solution with nervous tissue protecting agents and nervous tissue damage reversing agents.
Claim 17
Dependent Claim
12 words
The method of claim 12, wherein said oxygen carrying agents include perfluorocarbons.
Claim 18
Dependent Claim
27 words
The method of claim 12, wherein said injection point is at least one blood vessel whereby said solution uses the circulatory system in moving to the brain.
Claim 19
Dependent Claim
32 words
The method of claim 12, further including the step of employing a balloon catheter with a distal end valve, said catheter limiting reverse blood flow through the blood vessel toward the heart.
Claim 20
Dependent Claim
28 words
The method of claim 12, wherein said free radicals scavengers include the antioxidants: Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA, and Hydergine.
Claim 21
Dependent Claim
15 words
The method of claim 12, wherein said solution is cooled to approximately 40 degrees Fahrenheit.
Claim 22
Dependent Claim
20 words
The method of claim 14, wherein said nervous tissue protecting agents and said nervous tissue damage reversing agents include Lazaroids.
Claim 23
Independent Claim
136 words
A method of treating anoxic and/or ischemic brain and associated nervous tissue injury comprising: a. providing a portable brain resuscitation device including: i. at least one fluid reservoir containing brain resuscitation solution; ii. oxygenating means in fluid communication with said reservoir; iii. means for controlling the temperature of said resuscitation solution, said temperature controlling means being in fluid communication with said reservoir; iv. injection means for moving said solution from said device to a patient, said injecting means being removably attached to said portable brain resuscitation device at a point in communication with said temperature adjusting means; b. cooling said brain resuscitation solution to substantially below body temperature so as to slow the metabolic rate of the brain and associated nervous tissues; c. injecting said cooled fluid into an injection point along the patient's circulatory system.
Claim 24
Independent Claim
136 words
A method of treating anoxic and/or ischemic brain and associated nervous tissue injury comprising: a. providing a portable brain resuscitation device including: i. at least one fluid reservoir containing brain resuscitation solution; ii. oxygenating means in fluid communication with said reservoir; iii. means for controlling the temperature of said resuscitation solution, said temperature controlling means being in fluid communication with said reservoir; iv. injection means for moving said solution from said device to a patient, said injecting means being removably attached to said portable brain resuscitation device at a point in communication with said temperature adjusting means; b. cooling said brain resuscitation solution to substantially below body temperature so as to slow the metabolic rate of the brain and associated nervous tissues; c. injecting said cooled fluid into an injection point along the patient's circulatory system.
Claim 25
Dependent Claim
42 words
The method of claim 21, wherein said method involves the initial step of applying means to a patient for shunting all effective cardiac output away from the lower extremities and lower abdomen to the internal organs including the heart and the brain.
Claim 26
Dependent Claim
12 words
The method of claim 21, wherein said oxygenating means includes an oxygenator.
Claim 27
Dependent Claim
14 words
The method of claim 21, wherein said temperature controlling means includes a heat exchanger.
Claim 28
Dependent Claim
20 words
The method of claim 21, wherein said injecting means includes a balloon catheter with a valve at its distal end.
Claim 29
Dependent Claim
15 words
The method of claim 21, wherein said injection point is at least one blood vessel.
Claim 30
Dependent Claim
26 words
The method of claim 21, wherein said solution is cooled to approximately 40 degrees Fahrenheit, so as to hypothermically shock the brain and associated neurologic tissues.
Claim 31
Dependent Claim
76 words
The method of claim 21, wherein said brain resuscitation solution comprises: a. barbiturates, in an amount effective to induce a coma in the brain and associated nervous tissues, whereby metabolic rates of said tissues are slowed; b. oxygen carrying agents in an amount effective to transport oxygen to the brain and associated nervous tissues; and c. free radical scavengers, in an amount effective to reverse the oxidative state and inhibit free radical production within said tissues.
Claim 32
Dependent Claim
25 words
The method of claim 28 wherein said brain resuscitation fluid additionally comprises an effective amount of nervous tissue protecting and nervous tissue damage reversing agents.
Claim 33
Dependent Claim
12 words
The method of claim 28 wherein said oxygen carrying agents include perfluorocarbons.
Claim 34
Dependent Claim
12 words
The method of claim 28 wherein said free radicals scavengers include antioxidants.
Claim 35
Dependent Claim
24 words
The method of claim 31, wherein said antioxidants comprise: Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA, and Hydergine.
Claim 36
Dependent Claim
18 words
The method of claim 29, wherein said nervous tissue protecting and nervous tissue damage reversing agents include Lazaroids.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-09-22 | 1996-03-23 | 1996-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-22 | 2000-03-23 | 2000-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-22 | 2004-03-23 | 2004-09-22 | $7700.00 | Window Closed / Lapsed |