US5073171A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible materials comprising albumin-binding dyes
Assignee: Individual
•
Filing: 1989-01-12
•
Granted: 1991-12-17
•
Expires: 2009-01-12
Abstract
Abstract A biocompatible prosthetic device is provided which comprises a solid polymeric body incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. A method of increasing the albumin-binding ability of a prosthetic device is also provided.
Inventors
- 👤 John W. Eaton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:56
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/12; A61L33/128; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
43 words
A biocompatible prosthetic device having a solid polymeric body incorporating an amount of an albumin-binding dye effective to provide a means to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
Claim 2
Dependent Claim
43 words
A biocompatible prosthetic device having a solid polymeric body incorporating an amount of an albumin-binding dye effective to provide a means to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
Claim 3
Dependent Claim
16 words
The biocompatible prosthetic device of claim 1 wherein said albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 4
Dependent Claim
25 words
The biocompatible prosthetic device of claim 2 wherein said aromatic albumin-binding dye comprises a diazo dye; a sulfonic acid dye; or the physiologically-acceptable salts thereof.
Claim 5
Dependent Claim
41 words
The biocompatible prosthetic device of claim 3 wherein said aromatic albumin-binding dye is selected from the group consisting of Reactive Blue 2, Evans Blue, Trypan Blue, Bromcresol Green, Bromcresol Purple, Methyl Orange, 2-(4'-hydroxyazobenzene)benzoic acid, Procion red HE 3B, and mixtures thereof.
Claim 6
Dependent Claim
19 words
The biocompatible prosthetic device of claim 1 wherein said albumin-binding dye is conjugated to a physiologically acceptable water-soluble polysaccharide.
Claim 7
Dependent Claim
12 words
The biocompatible prosthetic device of claim 5 wherein said polysaccharide comprises dextran.
Claim 8
Dependent Claim
16 words
The biocompatible prosthetic device of claim 6 wherein said albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 9
Dependent Claim
40 words
The biocompatible prosthetic device of claim 7 wherein said aromatic albumin-binding dye comprises a diazo dye; a physiologically acceptable salt of said diazo dye; a sulfonic acid dye; a physiologically acceptable salt of said sulfonic acid dye; or mixtures thereof.
Claim 10
Dependent Claim
41 words
The biocompatible prosthetic device of claim 8 wherein said aromatic albumin-binding dye is selected from the group consisting of Reactive Blue 2, Evans Blue, Trypan Blue, Bromcresol Green, Bromcresol Purple, Methyl Orange, 2-(4'-hydroxyazobenzene)benzoic acid, Procion red HE 3B, and mixtures thereof.
Claim 11
Dependent Claim
23 words
The biocompatible prosthetic device of claim 1 wherein said solid polymeric body comprises a polyurethane, a silicone elastomer, a polycarbonate, or mixtures thereof.
Claim 12
Dependent Claim
14 words
The biocompatible prosthetic device of claim 10 wherein said polyurethane comprises a polyether polyurethane.
Claim 13
Dependent Claim
16 words
The biocompatible prosthetic device of claim 10 wherein said silicone elastomer comprises a medical grade elastomer.
Claim 14
Dependent Claim
15 words
The biocompatible prosthetic device of claim 1 wherein the endogenous albumin is human serum albumin.
Claim 15
Dependent Claim
13 words
The biocompatible prosthetic device of claim 1 wherein said device is a catheter.
Claim 16
Dependent Claim
14 words
The biocompatible prosthetic device of claim 1 wherein said device is a heart valve.
Claim 17
Dependent Claim
14 words
The biocompatible prosthetic device of claim 1 wherein said device is a vascular graft.
Claim 18
Dependent Claim
20 words
The biocompatible prosthetic device of claim 1 wherein the physiological fluid is blood, lymph, saliva, urine, tears or cerebro-spinal fluid.
Claim 19
Independent Claim
74 words
A method of increasing the albumin-binding ability of a prosthetic device having a solid polymeric body, said method comprising the step of: (a) incorporating into said polymeric body an amount of an albumin-binding dye; wherein the amount of the albumin binding dye is effective to provide a means to form a coating of endogenous albumin on a surface of said polymeric body when the surface is in contact with a physiological fluid containing albumin.
Claim 20
Independent Claim
74 words
A method of increasing the albumin-binding ability of a prosthetic device having a solid polymeric body, said method comprising the step of: (a) incorporating into said polymeric body an amount of an albumin-binding dye; wherein the amount of the albumin binding dye is effective to provide a means to form a coating of endogenous albumin on a surface of said polymeric body when the surface is in contact with a physiological fluid containing albumin.
Claim 21
Dependent Claim
14 words
The method of claim 18 wherein the albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 22
Dependent Claim
38 words
The method of claim 19 wherein the aromatic albumin-binding dye comprises a diazo dye; a physiologically acceptable salt of said diazo dye; a sulfonic acid dye; a physiologically acceptable salt of said sulfonic acid dye; or mixtures thereof.
Claim 23
Dependent Claim
39 words
The method of claim 20 wherein the aromatic albumin-binding dye is selected from the group consisting of Reactive Blue 2, Evans Blue, Trypan Blue, Bromcresol Green, Bromcresol Purple, Methyl Orange, 2-(4-hydroxyazobenzene)benzoic acid, Procion red HE 3B, and mixtures thereof.
Claim 24
Dependent Claim
18 words
The method of claim 18 wherein the physiological fluid is blood, lymph, saliva, urine, tears, or cerebrospinal fluid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-16 | 1995-06-17 | 1995-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-16 | 1999-06-17 | 1999-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-16 | 2003-06-17 | 2003-12-17 | $7700.00 | Window Closed / Lapsed |