Method for preventing and treating thrombosis

Claim 1

A method for treating a condition in an individual comprising administering a compound in an amount effective to prevent aggregation of blood platelets to an individual in need of said treatment wherein said condition is selected from the group consisting of arterial thrombosis and venous thromboembolism and wherein said compound is selected from the group having the formulas. X 1 --N═N--Y 1 --Q--Y 2 --N═N--X 2 and ##STR10## and salts thereof wherein X 1 and X 2 are ##STR11## Y 1 and Y 2 are ##STR12## Z 1 , Z 2 and Z 3 are benzyl groups substituted in one or more positions with hydrogen groups, carboxyl groups or hydroxyl groups, Q is a bond between the adjacent aryl or substituted aryl groups or a ureylene group or an alkylene or substituted alkylene group, and R 1 -R 7 is selected from the group consisting of hydrogen, a hydroxyl group, an amino group, a sulfate group, a phosphate group, a nitrate group, a nitrite group, a carboxyl group, an ester group, an ether group, an alkyl group, and salts of the aforementioned acidic substituents; and R 8 -R 12 is selected from the group consisting of hydrogen, a lower alkyl group, an alkyl ether group and a lower alkanoyl oxy group, and salts thereof.

Claim 2

A method for treating a condition in an individual comprising administering a compound in an amount effective to prevent aggregation of blood platelets to an individual in need of said treatment wherein said condition is selected from the group consisting of arterial thrombosis and venous thromboembolism and wherein said compound is selected from the group having the formulas. X 1 --N═N--Y 1 --Q--Y 2 --N═N--X 2 and ##STR10## and salts thereof wherein X 1 and X 2 are ##STR11## Y 1 and Y 2 are ##STR12## Z 1 , Z 2 and Z 3 are benzyl groups substituted in one or more positions with hydrogen groups, carboxyl groups or hydroxyl groups, Q is a bond between the adjacent aryl or substituted aryl groups or a ureylene group or an alkylene or substituted alkylene group, and R 1 -R 7 is selected from the group consisting of hydrogen, a hydroxyl group, an amino group, a sulfate group, a phosphate group, a nitrate group, a nitrite group, a carboxyl group, an ester group, an ether group, an alkyl group, and salts of the aforementioned acidic substituents; and R 8 -R 12 is selected from the group consisting of hydrogen, a lower alkyl group, an alkyl ether group and a lower alkanoyl oxy group, and salts thereof.

Claim 3

A method for treating thrombosis in an individual comprising administering a compound in an amount effective to prevent aggregation of blood platelets to an individual in need of said treatment wherein said compound is selected from the group having the formulas X 1 --N═N--Y 1 --Q--Y 2 --N═N--X 2 and ##STR13## and salts thereof wherein X 1 and X 2 are ##STR14## Y 1 and Y 2 are ##STR15## Z 1 , Z 2 and Z 3 are benzyl groups substituted in one or more positions with hydrogen groups, carboxyl groups or hydroxyl groups, Q is a bond between the adjacent aryl or substituted aryl groups or a ureylene group or an alkylene or substituted alkylene group, and R 1 -R 7 is selected from the group consisting of hydrogen, a hydroxyl group, an amino group, a sulfate group, a phosphate group, a nitrate group, a nitrite group, a carboxyl group, an ester group, an ether group, an alkyl group, and salts of the aforementioned acidic substituents; and R 8 -R 12 is selected from the group consisting of hydrogen, a lower alkyl group, an alkyl ether group and a lower alkanoyl oxy group, and salts thereof.

Claim 4

A method for treating thrombosis in an individual comprising administering a compound in an amount effective to prevent aggregation of blood platelets to an individual in need of said treatment wherein said compound is selected from the group having the formulas X 1 --N═N--Y 1 --Q--Y 2 --N═N--X 2 and ##STR13## and salts thereof wherein X 1 and X 2 are ##STR14## Y 1 and Y 2 are ##STR15## Z 1 , Z 2 and Z 3 are benzyl groups substituted in one or more positions with hydrogen groups, carboxyl groups or hydroxyl groups, Q is a bond between the adjacent aryl or substituted aryl groups or a ureylene group or an alkylene or substituted alkylene group, and R 1 -R 7 is selected from the group consisting of hydrogen, a hydroxyl group, an amino group, a sulfate group, a phosphate group, a nitrate group, a nitrite group, a carboxyl group, an ester group, an ether group, an alkyl group, and salts of the aforementioned acidic substituents; and R 8 -R 12 is selected from the group consisting of hydrogen, a lower alkyl group, an alkyl ether group and a lower alkanoyl oxy group, and salts thereof.

Claim 5

The method of claims 1 or 2, wherein said compound is selected from the group having the formula X 1 --N═N--Y 1 --Q--Y 2 --N═N--X 2 and salts thereof wherein X 1 and X 2 are ##STR16## Y 1 and Y 2 are ##STR17## Q is a bond between the adjacent aryl or substituted aryl groups or a ureylene group or an alkylene or substituted alkylene group, and R 1 -R 7 is selected from the group consisting of hydrogen, a hydroxyl group, an amino group, a sulfate group, a phosphate group, a nitrate group, a nitrite group, a carboxyl group, an ester group, an ether group, an alkyl group, and salts of the aforementioned acidic substituents; and R 8 -R 12 is selected from the group consisting of hydrogen, a lower alkyl group, an alkyl ether group and a lower alkanoyl oxy group.

Claim 14

A method for dissociating platelet aggregates comprising administering a platelet aggregate disassociating amount of a compound selected from the group consisting of aurin tricarboxylic acid, analogs of aurin tricarboxylic acid, agonists of aurin tricarboxylic acid, triphenyl methyl dyes, analogs of triphenyl methyl dyes, agonists of triphenyl methyl dyes, and naphthalene sulfonic acid substituted compounds to an individual in need of said treatment.

Claim 15

A method for dissociating platelet aggregates comprising administering a platelet aggregate disassociating amount of a compound selected from the group consisting of aurin tricarboxylic acid, analogs of aurin tricarboxylic acid, agonists of aurin tricarboxylic acid, triphenyl methyl dyes, analogs of triphenyl methyl dyes, agonists of triphenyl methyl dyes, and naphthalene sulfonic acid substituted compounds to an individual in need of said treatment.

Claim 16

The method of claims 1 or 2 wherein said compound is selected from the group having the formula ##STR18## and salts thereof wherein Z 1 , Z 2 and Z 3 are benzyl groups substituted in one or more positions with hydrogen groups, carboxyl groups or hydroxyl groups.