US5059123A — Periodontal barrier and method for aiding periodo…

Claim 1

Independent Claim 126 words

A method for aiding and guiding periodontal tissue regeneration, comprising the steps of: incorporating at least one carrier agent and time-release microshapes encapsulating at least one chemotherapeutic agent into a biocompatible periodontal barrier so as to provide for sustained, controlled delivery and improved cellular uptake of said at least one chemotherapeutic agent to a localized periodontal regeneration site in a mammalian body; and implanting said barrier at said localized periodontal regeneration site, wherein said time-release microshapes will begin to release said at least one chemotherapeutic agent at said localized periodontal regeneration site in a sustained, controlled manner, and further wherein said at least one carrier agent will provide for the improved cellular uptake of said at least one chemotherapeutic agent at the localized periodontal treatment site.

Claim 2

Independent Claim 126 words

A method for aiding and guiding periodontal tissue regeneration, comprising the steps of: incorporating at least one carrier agent and time-release microshapes encapsulating at least one chemotherapeutic agent into a biocompatible periodontal barrier so as to provide for sustained, controlled delivery and improved cellular uptake of said at least one chemotherapeutic agent to a localized periodontal regeneration site in a mammalian body; and implanting said barrier at said localized periodontal regeneration site, wherein said time-release microshapes will begin to release said at least one chemotherapeutic agent at said localized periodontal regeneration site in a sustained, controlled manner, and further wherein said at least one carrier agent will provide for the improved cellular uptake of said at least one chemotherapeutic agent at the localized periodontal treatment site.

Claim 3

Dependent Claim 16 words

The method of claim 1 wherein the carrier agent is hyaluronic acid or a derivative thereof.

Claim 4

Dependent Claim 16 words

The method of claim 2 wherein the carrier agent is encapsulated in a time release microshape.

Claim 5

Dependent Claim 32 words

The method of claim 2 wherein the carrier agent is mixed with at least one chemotherapeutic agent and encapsulated in said time-release microshape prior to incorporating said time-release microshape into said implant.

Claim 6

Dependent Claim 17 words

The method of claim 1 wherein the incorporating step includes selecting a biocompatible barrier which is nonresorbable.

Claim 7

Dependent Claim 34 words

The method of claim 5 wherein said incorporating step includes selecting a biocompatible, nonresorbable barrier composed of a material selected from the group consisting of polytetrafluoroethylene, dacron, proplast, polypropylene and ethers of hyaluronic acid.

Claim 8

Dependent Claim 17 words

The method of claim 1 wherein the incorporating step includes selecting a biocompatible barrier which is resorbable.

Claim 9

Dependent Claim 27 words

The method of claim 7 wherein the incorporating step includes selecting a bicompatible, resorbable barrier from the group consisting of crosslinked collagen or esters of hyaluronic acid.

Claim 10

Dependent Claim 24 words

The method of claim 1 wherein the incorporating step includes selecting microshapes from the group consisting of microspheres, microfibrils, microfibers, hollow microfibers and microsponges.

Claim 11

Dependent Claim 40 words

The method of claim 9 wherein the incorporating step includes selecting microshapes from the group consisting of microspheres sized between approximately 10 to 700 microns in diameter and hollow microfibers having a crosssectional diameter between approximately 100 to 1000 microns.

Claim 12

Dependent Claim 37 words

The method of claim 1 wherein the incorporating step includes selecting time-release microshapes encapsulating said chemotherapeutic agents which have time release values, thereby assuring generally continuous release of said chemotherapeutic agents over a predetermined period of time.

Claim 13

Dependent Claim 21 words

The method of claim 11 wherein the incorporating step includes mixing said chemotherapeutic agent with a polymer comprising said time-release microshape.

Claim 14

Dependent Claim 15 words

The method of claim 12 wherein the mixing step includes selecting a biocompatible, non-resorbable polymer.

Claim 15

Dependent Claim 15 words

The method of claim 12 wherein the mixing step includes selecting a biodegradable, resorbable polymer.

Claim 16

Independent Claim 47 words

The method of claims 13 or 14 wherein the mixing step includes selecting the polymer from the group consisting of collagen, cellulosic polymers, ethylene vinyl acetate, methacrylate polymers, lactic glycolic acid polymers, polycaprolactone, polylactides, polystyrene, polycarbonate, polysulfone, polyurethane, esters of hyaluronic acid and ethers of hyaluronic acid.

Claim 17

Dependent Claim 43 words

The method of claim 1 wherein the incorporating step includes selecting microshapes for incorporation into said barriers which are surrounded by a polymeric wall or shell, thereby providing for continuous or periodic release of said chemotherapeutic agents over a predetermined period of time.

Claim 18

Dependent Claim 26 words

The method of claim 1 wherein the incorporating step includes selecting the chemotherapeutic agent from the group consisting of antibacterial, antibiotic, anti-inflammatory and tissue regenerative agents.

Claim 19

Dependent Claim 27 words

The method of claim 17 wherein the incorporating step includes selecting the antibacterial agent from the group consisting of bisbiguanides, fluorides, iodine, heavy metal salts and sulfonamides.

Claim 20

Dependent Claim 28 words

The method of claim 17 wherein the incorporating step includes selecting the antibiotic agent from the group consisting of vancomycin, tetracycline, penicillin, cephalosporins, erythromycin, metronidazole, neomycin and kanamycin.

Claim 21

Dependent Claim 26 words

The method of claim 17 wherein the incorporating step includes selecting the anti-inflammatory agent from the group consisting of steroidal anti-inflammatory agents and nonsteroidal anti-inflammatory agents.

Claim 22

Dependent Claim 27 words

The method of claim 20 wherein the incorporating step includes the a nonsteroidal anti-inflammatory agent from the group consisting of indomethacin, flurbiprofen, meclofenamic acid, ibuprofen and naproxen.

Claim 23

Dependent Claim 26 words

The method of claim 17 wherein the incorporating step includes selecting the steroidal anti-inflammatory agent from the group consisting of cortisone, hydrocortisone, beta-methasone, dexamethasone and prednisolone.

Claim 24

Dependent Claim 25 words

The method of claim 17 wherein the incorporating step includes selecting the tissue regenerative agent from the group consisting of fibronectin and bone morphogenic protein.

Claim 25

Dependent Claim 95 words

The method of claim 1 wherein the barrier comprises a body compatible material with a microstructure, and wherein the incorporating step is selected from the group consisting of incorporating said microshapes into said barrier by extruding said microshapes into the microstructures of said barrier, weaving said microshapes into the microstructure of said barrier, mixing said microshapes with a fluid and/or gel and flowing them into the microstructure of said barrier, placing said microshapes between one or more layers of said barrier and positioning said microshapes between said barrier and an elastomer coating covering said barrier.

Claim 26

Dependent Claim 21 words

The method of claim 24 wherein the fluid is hyaluronic acid and the gel is a cross-linked gel of hyaluronic acid.

Claim 27

Independent Claim 60 words

A method for aiding and guiding periodontal tissue regeneration, comprising incorporating at least one carrier agent and time-release microshapes encapsulating at least one chemotherapeutic agent into a biocompatible periodontal barrier, said barrier upon implanatation providing for sustained, controlled delivery and improved cellular uptake of said at least one chemotherapeutic agent to a localized periodontal regeneration site in a mammalian body.

Claim 28

Independent Claim 60 words

A method for aiding and guiding periodontal tissue regeneration, comprising incorporating at least one carrier agent and time-release microshapes encapsulating at least one chemotherapeutic agent into a biocompatible periodontal barrier, said barrier upon implanatation providing for sustained, controlled delivery and improved cellular uptake of said at least one chemotherapeutic agent to a localized periodontal regeneration site in a mammalian body.

Claim 29

Dependent Claim 16 words

The method of claim 26 wherein the carrier agent is hyaluronic acid or a derivative thereof.

Claim 30

Dependent Claim 15 words

The method of claim 27 wherein the carrier agent is encapsulated in a time-release microshape.

Claim 31

Dependent Claim 35 words

The method of claim 27 wherein the carrier agent is mixed with the at least one chemotherapeutic agent and encapsulated in said time-release microshapes prior to incorporating said time-release microshapes into the bicompatible periodontal barrier.

Claim 32

Dependent Claim 29 words

The method of claim 26 further comprising the step of selecting the microshapes from the group consisting of microspheres, microfibrils, microfibers, hollow microfibers and microsponges before the incorporating step.

Claim 33

Dependent Claim 28 words

The method of claim 30 further comprising the step of incorporating at least one predetermined chemotherapeutic agent into the selected microshapes before incorporating the microshapes into the barrier.

Claim 34

Dependent Claim 97 words

A periodontal barrier comprising: a body compatible material with a microstructure configured for aiding and guiding periodontal tissue growth adjacent a tooth; and at least one carrier agent, and time-release microparticles encapsulating at least one chemotherapeutic agent being incorporated into said microstructure, wherein said time release microparticles will begin to release said chematherapeutic agent at a localized periodontal tissue regeneration site upon surgical implanatation of said periodontal barrier, and further wherein said at least one carrier agent will provide for the improved cellular uptake of said at least one chemotherapeutic agent at the localized periodontal regeneration site.

Claim 35

Dependent Claim 97 words

A periodontal barrier comprising: a body compatible material with a microstructure configured for aiding and guiding periodontal tissue growth adjacent a tooth; and at least one carrier agent, and time-release microparticles encapsulating at least one chemotherapeutic agent being incorporated into said microstructure, wherein said time release microparticles will begin to release said chematherapeutic agent at a localized periodontal tissue regeneration site upon surgical implanatation of said periodontal barrier, and further wherein said at least one carrier agent will provide for the improved cellular uptake of said at least one chemotherapeutic agent at the localized periodontal regeneration site.

Claim 36

Dependent Claim 17 words

The periodontal barrier of claim 32 wherein the carrier agent is hyaluronic acid or a derivative thereof.

Claim 37

Dependent Claim 16 words

The periodontal barrier of claim 33 wherein the carrier agent is encapsulated in a time-release microparticle.

Claim 38

Dependent Claim 38 words

The periodontal barrier of claim 33 wherein the carrier agent is mixed with the at least one chemotherapeutic agent and encapsulated in said time-release microparticles prior to incorporating said time-release microparticles into the microstructure of the periodontal barrier.

Claim 39

Dependent Claim 15 words

The barrier of claim 32 wherein the barrier is constructed of a biodegradable, resorbable material.

Claim 40

Dependent Claim 19 words

The barrier of claim 36 wherein said biodegradable, resorbable material is cross-linked collagen or an ester of hyaluronic acid.

Claim 41

Dependent Claim 15 words

The barrier of claim 32 wherein the barrier is constructed of a biocompatible, nonresorbable material.

Claim 42

Dependent Claim 27 words

The barrier of claim 38 wherein said biocompatible, nonresorbable material is selected from the group consisting of polytetrafluoroethylene, dacron, proplast, polypropylene and an ether of hyaluronic acid.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1994-10-21	1995-04-22	1995-10-22	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1998-10-21	1999-04-22	1999-10-22	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2002-10-21	2003-04-22	2003-10-22	$7700.00	Window Closed / Lapsed

Periodontal barrier and method for aiding periodontal tissue regeneration

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag