US4321711A
Expired / Lapsed
US
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Vascular prosthesis
Assignee: Sumitomo Electric Industries Ltd
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Filing: 1979-10-12
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Granted: 1982-03-30
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Expires: 1999-10-12
Abstract
Abstract A vascular prosthesis comprising a porous tubing of polytetrafluoroethylene containing an anti-coagulant substance and bonded to its outside surface a porous elastomer coating containing substance which counteracts the anti-coagulant substance is disclosed.
Inventors
- 👤 Hiroshi Mano
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:06
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/00; A61L27/14; A61L27/16; A61L27/50; A61L27/507; A61L27/56
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
55 words
A vascular prosthesis comprising a porous polytetrafluoroethylene tubing having a microstructure composed of fibers and nodes, said nodes being connected to one another by the fibers, said tubing containing an anti-coagulant substance and having a porous elastomer coating bonded to the exterior thereof, said porous elastomer coating containing a substance which counteracts the anti-coagulant substance.
Claim 2
Dependent Claim
55 words
A vascular prosthesis comprising a porous polytetrafluoroethylene tubing having a microstructure composed of fibers and nodes, said nodes being connected to one another by the fibers, said tubing containing an anti-coagulant substance and having a porous elastomer coating bonded to the exterior thereof, said porous elastomer coating containing a substance which counteracts the anti-coagulant substance.
Claim 3
Dependent Claim
15 words
The vascular prosthesis of claim 1, wherein said anti-coagulant substance is heparin or its derivative.
Claim 4
Dependent Claim
25 words
The vascular prosthesis of claim 2, wherein said haparin or derivatives thereof is contained in said PTFE tubing ionically bonded to a crosslinked polymeric amine.
Claim 5
Dependent Claim
25 words
The vascular prosthesis of claim 3, wherein said anti-coagulant is contained in said polymeric gel in an amount of about 0.2 to 5% by weight.
Claim 6
Dependent Claim
17 words
The vascular prosthesis of claim 1, wherein said counteracting substance is an inorganic or organic coagulating substance.
Claim 7
Dependent Claim
14 words
The vascular prosthesis of claim 1, wherein said counteracting substance is a heparin antagonist.
Claim 8
Dependent Claim
15 words
The vascular prosthesis of claim 6, wherein said heparin antagonist is protamine or its derivative.
Claim 9
Dependent Claim
38 words
The vasular prosthesis of claim 1, wherein said PTFE tubing has a pore diameter of about 2 to about 100 μm, a porosity of at least about 70% and a wall thickness of about 0.3 to 1.0 mm.
Claim 10
Dependent Claim
42 words
The vascular prosthesis of claim 8, wherein said porous elastomer coating has an average pore diameter of about 10 μm to about 500 μm, a thickness of about 20 to about 500 μm and a porosity of about 50 to about 95%.
Claim 11
Dependent Claim
27 words
The vascular prosthesis of claim 1, wherein said elastomer is selected from the group consisting of fluorine rubber, silicone rubber, urethane rubber, acrylic rubber, and natural rubber.
Claim 12
Dependent Claim
18 words
The vascular prosthesis of claim 10, wherein said elastomer has a porosity of about 50% to about 90%.
Claim 13
Dependent Claim
18 words
The vascular prosthesis of claim 11, wherein said elastomer coating is about 20 to about 500 μm thick.
Claim 14
Dependent Claim
21 words
The vascular prosthesis of claim 1, wherein said anti-coagulant is selected from the group consisting of polysaccharide sulfates and organic acids.
Claim 15
Dependent Claim
27 words
The vascular prosthesis of claim 13, wherein said anti-coagulant is selected from the group consisting of heparin and derivatives thereof, chondroitin sulfate, charonin sulfate, and citric acid.
Claim 16
Dependent Claim
20 words
The vascular prosthesis of claim 1, wherein said anti-coagulant is contained in said PTFE tubing dispersed in a polymeric gel.
Claim 17
Dependent Claim
31 words
The vascular prosthesis of claim 1, wherein said substance which counteracts the anti-coagulant is selected from the group consisting of silica, alumina, carbon black, activated carbon, and antagonistic agents for anti-coagulants.
Claim 18
Dependent Claim
36 words
The vascular prosthesis of claim 1, wherein said substance which counteracts the anti-coagulant is present with said elastomer in an amount of about 0.5% to about 10% by weight based on the weight of the elastomer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-29 | 1985-09-28 | 1986-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-29 | 1989-09-28 | 1990-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-29 | 1993-09-28 | 1994-03-30 | $7700.00 | Window Closed / Lapsed |