US4226848A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and preparation for administration to the mucosa of the oral or nasal cavity
Assignee: Teijin Ltd
•
Filing: 1979-03-02
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Granted: 1980-10-07
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Expires: 1999-03-02
Abstract
Abstract A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and (b) dispersed therein, pharmaceutically effective amount of the medicament, said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally; said mucosa-adhesive preparation; and process for said preparation.
Inventors
- 👤 Tsuneji Nagai
- 👤 Yoshiharu Machida
- 👤 Yoshiki Suzuki
- 👤 Hiroshi Ikura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:37
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0043; A61K9/0053; A61K9/006; A61K47/00; A61K47/30; A61K47/32; A61K47/36; A61K47/38
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
95 words
A method for administering a medicament which comprises adhering to the mucosa of the nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and (b) dispersed therein, a pharmaceutically effective amount of the medicament, said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally.
Claim 2
Independent Claim
95 words
A method for administering a medicament which comprises adhering to the mucosa of the nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and (b) dispersed therein, a pharmaceutically effective amount of the medicament, said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally.
Claim 3
Dependent Claim
42 words
The method of claim 1 wherein said polymeric matrix comprises about 65 to about 90% by weight of the cellulose ether and about 35 to about 10% by weight of the homo- or copolymer of acrylic acid or its pharmaceutically acceptable salt.
Claim 4
Dependent Claim
20 words
The method of claim 1 wherein the cellulose ether is a lower alkyl or hydroxy lower alkyl ether of cellulose.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein the cellulose ether is selected from the group consisting of methyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose and hydroxypropyl cellulose.
Claim 6
Dependent Claim
32 words
The method of claim 1 wherein the cellulose ether is hydroxypropyl cellulose having a viscosity, determined at 20° C. for a 2% by weight aqueous solution thereof, of 3 to 10,000 centipoises.
Claim 7
Dependent Claim
54 words
The method of claim 1 wherein the polymer of acrylic acid has a viscosity of 360 to 165,000 centipoises when it is measured at 25.0±5° C. for an aqueous solution of the sodium salt of the polymer having a pH of 7 to 7.5 and a concentration of 0.2% by weight as free polymer.
Claim 8
Dependent Claim
17 words
The method of claim 1 wherein the pharmaceutical preparation further comprises an excipient dispersed in the matrix.
Claim 9
Dependent Claim
58 words
The method of claim 1 wherein the medicament is selected from the group consisting of analgesic and anti-inflammatory agents, anti-inflammatory enzyme preparations, anti-inflammatory steroids, antihistamines, antibiotics, antibacterial agents, chemotherapeutic agents, local anaesthesias, cardiac tonics, vasodilators, antitussive and expectorants, oral antiseptics, enzyme proteins, hypoglycemic agents, hemostats, hormones, hypotensive agents, sedatives or tranquilizers, anti-tumor agents, gastro intestinal drugs and antacids.
Claim 10
Dependent Claim
22 words
The method of claim 1 wherein the pharmaceutical preparation is in the form of tablets, granules, fine granules, powders and dental cone.
References Cited (Backward Citations)
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US3511791A
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US3440065A
Cited
US3833518A
Cited
US3868259A
Cited
US3868432A
Cited
US4059686A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-07 | 1984-04-07 | 1984-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-07 | 1988-04-07 | 1988-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-07 | 1992-04-07 | 1992-10-07 | $7700.00 | Window Closed / Lapsed |