US4776890A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of collagen hydroxyapatite matrix for bone repair
Assignee: Angiotech Biomaterials Corp
•
Filing: 1987-04-03
•
Granted: 1988-10-11
•
Expires: 2007-04-03
Abstract
Abstract An improved process for obtaining a matrix of mineral particles in reconstituted atelopeptide collagen comprises reconstituting a mixture of mineral particles with collagen in solution. This process results in a matrix of collagen containing the mineral particles which, when wetted, is malleable and retains its integrity.
Inventors
- 👤 George Chu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:19
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
53 words
A method to prepare a mineral collagen matrix having mineral particles retained within a native collagen matrix, which method comprises dialyzing a mixture of mineral particles and non-fibrillar collagen in acidic solution against a reconstituting medium, said reconstituting medium comprising a precipitating, buffer solution selected so as to promote native collagen fiber formation.
Claim 2
Independent Claim
53 words
A method to prepare a mineral collagen matrix having mineral particles retained within a native collagen matrix, which method comprises dialyzing a mixture of mineral particles and non-fibrillar collagen in acidic solution against a reconstituting medium, said reconstituting medium comprising a precipitating, buffer solution selected so as to promote native collagen fiber formation.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the mixture contains 1-10% collagen wt/wt of total solids.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein the reconstituting solution is phosphate buffer at physiological pH and ionic strength.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the dialysis is conducted to maintain sterile conditions within the dialysis container.
Claim 6
Dependent Claim
12 words
The process of claim 4 which further includes drying the reconstituted matrix.
Claim 7
Dependent Claim
17 words
The process of claim 1 wherein the collagen in solution is at a concentration of 35-120 mg/ml.
Claim 8
Dependent Claim
12 words
The process of claim 1 wherein the mineral particles are hydroxylapatite particles.
Claim 9
Dependent Claim
13 words
The process of claim 7 wherein the hydroxylapatite is 20/40 or 40/60 mesh.
Claim 10
Dependent Claim
9 words
The matrix prepared by the method of claim 1.
Claim 11
Dependent Claim
17 words
A method for repairing bone defects which comprises administering to said defect the composition of claim 9.
References Cited (Backward Citations)
US3767437A
Cited
US3913229A
Cited
US4488911A
Cited
US4097935A
Cited
US4186486A
Cited
US4451235A
Cited
US4349470A
Cited
US4516276A
Cited
US4557764A
Cited
US4563350A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-11 | 1992-04-11 | 1992-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-11 | 1996-04-11 | 1996-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-11 | 2000-04-11 | 2000-10-11 | $7700.00 | Window Closed / Lapsed |