Patent US5865849A successfully refreshed from Google Patents.
US5865849A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Meniscal heterografts
Assignee: Aperion Biologics Inc
•
Filing: 1995-06-07
•
Granted: 1999-02-02
•
Expires: 2015-06-07
Abstract
Abstract The invention provides an article of manufacture comprising a substantially non-immunogenic knee meniscal heterografts for implantation into humans. The invention further provides a method for preparing a knee meniscal heterograft by removing at least a portion of a meniscus from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic meniscus.
Inventors
- 👤 Kevin R. Stone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:16
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30756; A61F2/38; A61F2/3872; A61L27/3604; A61L27/3612; A61L27/3641; A61L27/3645; A61L27/3654; A61L27/3687; A61F2/3094; A61F2/28; A61F2002/2835; A61L2430/00; A61L2430/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
98 words
A method of preparing a meniscal heterograft for implantation into a human, which comprises a. removing at least a portion of a medial or lateral meniscus from a knee joint of a non-human animal to provide a heterograft; b. washing the heterograft in water and alcohol; c. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling, whereby the heterograft has substantially the same mechanical properties as the meniscus; and d. treating the hetero graft with a glycosidase to remove surface carbohydrate moieties.
Claim 2
Independent Claim
98 words
A method of preparing a meniscal heterograft for implantation into a human, which comprises a. removing at least a portion of a medial or lateral meniscus from a knee joint of a non-human animal to provide a heterograft; b. washing the heterograft in water and alcohol; c. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling, whereby the heterograft has substantially the same mechanical properties as the meniscus; and d. treating the hetero graft with a glycosidase to remove surface carbohydrate moieties.
Claim 3
Dependent Claim
48 words
The method according to claim 1, wherein the heterograft comprises a superior principal surface and an inferior principal surface, the outer portions of said principal surfaces being joined by an outer lateral surface, and the inner portions of said principal surfaces being joined by an inner lateral surface.
Claim 4
Dependent Claim
23 words
The method according to claim 2, comprising the further step performed prior step c of piercing the heterograft on the outer lateral surface.
Claim 5
Dependent Claim
21 words
The method according to claim 1 comprising the further step following step c of treating the heterograft with a second enzyme.
Claim 6
Dependent Claim
19 words
The method of claim 4 wherein said second enzyme is selected from the group consisting of ficin and trypsin.
Claim 7
Dependent Claim
35 words
The method of claim 1, comprising the further step following step c of treating the heterograft with one or more agents selected from the group consisting of anticalcification agents, antithrombotic agents, antibiotics, and growth factors.
Claim 8
Dependent Claim
16 words
The method of claim 1, comprising the further step following step c of sterilizing the heterograft.
Claim 9
Dependent Claim
31 words
The method of claim 7, wherein said sterilizing step is selected from the group consisting of treatment with glutaraldehyde, treatment with formaldehyde, treatment with ethylene oxide, and treatment with propylene oxide.
Claim 10
Dependent Claim
19 words
The method of claim 1, wherein the subjecting step comprises subjecting the heterograft to a treatment of freeze/thaw cycling.
References Cited (Backward Citations)
US4034418A
Cited
US4344193A
Cited
US4400833A
Cited
US4502161A
Cited
US4502161B1
Cited
WO1984003036A1
Cited
US4642120A
Cited
US4801299A
Cited
US4609627A
Cited
US4932973A
Cited
US4597266A
Cited
US4678470A
Cited
US4627853A
Cited
US4755593A
Cited
US4776853A
Cited
US4846835A
Cited
US4880429A
Cited
US5007934A
Cited
US5158574A
Cited
US5306311A
Cited
US5078744A
Cited
US5071741A
Cited
US5116374A
Cited
US5067962A
Cited
US5171660A
Cited
US5131850A
Cited
US5171322A
Cited
US5092894A
Cited
US5306304A
Cited
US5160313A
Cited
US5507810A
Cited
US5358525A
Cited
US5613982A
Cited
WO1995026740A1
Cited
WO1995028412A1
Cited
WO1995033828A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-01 | 2002-08-03 | 2003-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-01 | 2006-08-03 | 2007-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-01 | 2010-08-03 | 2011-02-02 | $7700.00 | Window Closed / Lapsed |