US4846835A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Technique for healing lesions in cartilage
Assignee: Individual
•
Filing: 1987-06-15
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Granted: 1989-07-11
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Expires: 2007-06-15
Abstract
Abstract A grafting technique entailing the transplantation of chondrocytes for promoting the healing of lesions in articular cartilage, use being made for this purpose of in vitro autologous cultured chondrocytes prior to transplantation. The chondrocytes are preferably seeded in a three-dimensional collagen matrix which serves as the graft material. In order to internally fix the graft during the healing process, use is made of a periosteal flap which is sutured to the cartilage after the graft material is implanted therein.
Inventors
- 👤 Daniel A. Grande
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 17:14
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0652; C12N5/0655; A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30756; A61K; A61K35/00; A61K35/12; A61K35/32; A61L; A61L27/00; A61L27/36; A61L27/38; A61F2/28; A61F2/2846; A61F2310/00; A61F2310/00005; A61F2310/00365; C12N2500/00; C12N2500/30; C12N2500/32; C12N2533/00; C12N2533/50; C12N2533/54
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
80 words
A grafting technique for promoting the healing of an articular cartilage lesion comprising the steps of: A: producing in vitro autologous cultured chondrocytes prior to grafting; B: seeding a collagen matrix with the cultured chondrocytes to provide an activated matrix; C: implanting the activated collagen matrix in the lesion to be treated to provide a graft; and D: mechanically fixing the graft by a periosteal flap sutured to the cartilage so that it remains in place during the healing process.
Claim 2
Dependent Claim
80 words
A grafting technique for promoting the healing of an articular cartilage lesion comprising the steps of: A: producing in vitro autologous cultured chondrocytes prior to grafting; B: seeding a collagen matrix with the cultured chondrocytes to provide an activated matrix; C: implanting the activated collagen matrix in the lesion to be treated to provide a graft; and D: mechanically fixing the graft by a periosteal flap sutured to the cartilage so that it remains in place during the healing process.
Claim 3
Dependent Claim
15 words
A technique as set forth in claim 1, wherein said matrix is a collagen gel.
Claim 4
Dependent Claim
15 words
A technique as set forth in claim 1, wherein said matrix is a collagen sponge.
Claim 5
Dependent Claim
29 words
A grafting technique as set forth in claim 1, wherein said collagen matrix is constituted by a collagen gel in which the chondrocytes are dispersed prior to its polymerization.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |