US5507810A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Processing of fibrous connective tissue
Assignee: Warsaw Orthopedic Inc
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Filing: 1992-12-21
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Granted: 1996-04-16
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Expires: 2012-12-21
Abstract
Abstract Fibrous connective tissue for surgical implantation is made substantially antigen-free by contact with one or more extraction agents. Solutions or mixtures of molecules having bipolar regions act as antigen removing permeation enhancers. Cationic, anionic, non-ionic or amphoteric surfactants are suitable bipolar permeation enhancers. One or more extraction agents can be combined to form extraction mixtures.
Inventors
- 👤 Annamarie B. Prewett
- 👤 Robert K. O'Leary
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:01
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61K; A61K35/00; A61K35/12; A61K35/32; A61L27/3604; A61L27/3691; A61F; A61F2/00; A61F2/02; A61F2/08; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2430/00; A61L2430/10; A61L2430/40
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
63 words
A process for removing a material selected from the group consisting of antigens, antigen generating material, tendon cells, ligament cells, cellular debris and inflammatory agents from fibrous tissue comprising contacting the fibrous tissue with at least one extraction agent for a sufficient time to remove said material from the fibrous tissue, wherein the at least one extraction agent includes at least one polyol.
Claim 2
Dependent Claim
63 words
A process for removing a material selected from the group consisting of antigens, antigen generating material, tendon cells, ligament cells, cellular debris and inflammatory agents from fibrous tissue comprising contacting the fibrous tissue with at least one extraction agent for a sufficient time to remove said material from the fibrous tissue, wherein the at least one extraction agent includes at least one polyol.
Claim 3
Dependent Claim
23 words
A process according to claim 1 wherein the at least one extraction agent further comprises a C 3 -C 20 fatty acid ester.
Claim 4
Dependent Claim
26 words
A process according to claim 2 wherein the at least one extraction agent comprises a C 3 -C 20 fatty acid ester admixed with a polyol.
Claim 5
Dependent Claim
26 words
A process according to claim 3 wherein the C 3 -C 20 fatty acid ester is selected from the group consisting of monoglycerides, diglycerides and triglycerides.
Claim 6
Dependent Claim
18 words
A process according to claim 3 wherein the C 3 -C 20 fatty acid ester is glycerol monolaurate.
Claim 7
Dependent Claim
13 words
A process according to claim 4 wherein the polyol is an alkylene glycol.
Claim 8
Dependent Claim
13 words
A process according to claim 6 wherein the alkylene glycol is propylene glycol.
Claim 9
Dependent Claim
22 words
A process according to claim 3 wherein the at least one extraction agent comprises a mixture of glycerol monolaurate and propylene glycol.
Claim 10
Dependent Claim
25 words
A process according to claim 2, wherein said process is carried out in a temperature range of from about 4° C. to about 37° C.
Claim 11
Dependent Claim
40 words
A process according to claim 3, wherein the concentration of C 3 -C 20 fatty acid ester ranges from about 0.5% to about 80% by weight and the concentration of polyol ranges from about 20% to about 99.5% by weight.
Claim 12
Dependent Claim
32 words
A process according to claim 10, wherein the concentration of C 3 -C 20 fatty acid ester is about 1.9% by weight and the concentration of polyol is about 98.1% by weight.
Claim 13
Dependent Claim
27 words
A process according to claim 2, wherein the contact time of the fibrous tissue with the at least one extraction agent is at least about 30 minutes.
Claim 14
Dependent Claim
25 words
A process according to claim 12, wherein the contact time of the fibrous tissue with the at least one extraction agent is about 8 hours.
Claim 15
Dependent Claim
45 words
A process according to claim 2, wherein the at least one extraction agent is combined with at least one member selected from the group consisting of antibiotics, antifungals, antiviral agents, immunosuppressive agents, anti-inflammatory agents, growth factors, osteogenic factors, anticoagulants, antihistamines, hormones, enzymes, disinfectants and preservatives.
Claim 16
Dependent Claim
22 words
A process according to claim 2, wherein the at least one extraction agent is combined with a mixture of chloroform and methanol.
Claim 17
Dependent Claim
22 words
A process according to claim 2, further comprising agitation of the fibrous tissue and the at least one extraction agent during contact.
Claim 18
Dependent Claim
21 words
A process according to claim 2, further comprising sterilizing the fibrous tissue by exposure to a sterilizing dose of ultraviolet radiation.
Claim 19
Dependent Claim
25 words
A process according to claim 2 further comprising rinsing the fibrous tissue with a rinsing solution following contact with the at least one extraction agent.
Claim 20
Dependent Claim
38 words
A process according to claim 18, wherein the rinsing solution is selected from the group consisting of distilled water, purified water, sterilized water, sterile isotonic sodium chloride solution, Ringer's solution, lactated Ringer's solution and neutral buffered formalin solution.
Claim 21
Dependent Claim
20 words
A process according to claim 2, wherein the fibrous tissue is selected from the group consisting of tendons and ligaments.
Claim 22
Dependent Claim
13 words
A process according to claim 2, wherein the fibrous tissue is mammalian tissue.
Claim 23
Dependent Claim
24 words
A process according to claim 2, wherein the fibrous tissue is selected from the group consisting of allograft fibrous tissue and xenograft fibrous tissue.
Claim 24
Dependent Claim
15 words
A substantially antigen-free implantable fibrous tissue made substantially antigen-free by the process of claim 2.
Claim 25
Dependent Claim
24 words
A substantially antigen-free implantable fibrous tissue according to claim 23 wherein the fibrous tissue is selected from the group consisting of tendons and ligaments.
Claim 26
Dependent Claim
19 words
A substantially antigen-free implantable fibrous tissue according to claim 24 wherein the tendons and ligaments are mammalian in origin.
Claim 27
Dependent Claim
28 words
A substantially antigen-free implantable fibrous tissue according to claim 23 wherein the fibrous tissue is selected from the group consisting of allograft fibrous tissue and xenograft fibrous tissue.
Claim 28
Dependent Claim
16 words
An implantable fibrous tissue made substantially free of cellular debris by the process of claim 2.
Claim 29
Dependent Claim
26 words
An implantable fibrous tissue according to claim 27 wherein the fibrous tissue is selected from the group consisting of allograft fibrous tissue and xenograft fibrous tissue.
Claim 30
Dependent Claim
16 words
An implantable fibrous tissue according to claim 27, wherein the fibrous tissue is mammalian in origin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-16 | 1999-10-16 | 2000-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-16 | 2003-10-16 | 2004-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-16 | 2007-10-16 | 2008-04-16 | $7700.00 | Window Closed / Lapsed |