Patent US5863296A successfully refreshed from Google Patents.
US5863296A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treated tissue for implantation and methods of treatment and use
Assignee: Artivion Inc
•
Filing: 1995-06-05
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Granted: 1999-01-26
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Expires: 2015-06-05
Abstract
Abstract Tissue which is suitable for transplant is treated with a growth factor and cells which populate the tissue and native cells must be removed, they cannot be "masked" reduce immunogenicity; this increases the longevity of the tissue upon transplant. The preferred growth factor is basic fibroblast growth factor, and the preferred cells are fibroblasts. The tissue can be an allograft or xenograft taken from a cow, pig or other mammal.
Inventors
- 👤 E. Christopher Orton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:09
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61F; A61F2/00; A61F2/0077; A61F2/02; A61F2/10; A61F2/24; A61L27/36; A61L27/3604; A61L27/3625; A61L27/3683; A61L27/3695; A61L27/38; A61L27/3804; A61L27/50; A61L27/54; A61F2/04; A61F2/06; A61F2/062; A61F2/2412; A61F2/2415; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/64; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/918; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
62 words
An implantable bodily tissue which has been harvested from a donor and subsequently treated with a growth factor and allogenic or autologous cells which populate the tissue, said tissue retaining the natural morphology of untreated tissue, said cells being effective for reducing an immune response to the tissue upon implant into a patient, and said growth factor being effective on said cells.
Claim 2
Dependent Claim
62 words
An implantable bodily tissue which has been harvested from a donor and subsequently treated with a growth factor and allogenic or autologous cells which populate the tissue, said tissue retaining the natural morphology of untreated tissue, said cells being effective for reducing an immune response to the tissue upon implant into a patient, and said growth factor being effective on said cells.
Claim 3
Dependent Claim
82 words
An implantable bodily tissue which has been harvested from a donor and which upon implant into a patient in untreated form would elicit an immune response, said tissue being treated prior to implant with a growth factor and allogenic or autologous cells which proliferate and populate the tissue in response to the growth factor, wherein said tissue retains the natural morphology of untreated tissue and said cells are effective for reducing an immune response of the patient to said tissue upon implant.
Claim 4
Dependent Claim
82 words
An implantable bodily tissue which has been harvested from a donor and which upon implant into a patient in untreated form would elicit an immune response, said tissue being treated prior to implant with a growth factor and allogenic or autologous cells which proliferate and populate the tissue in response to the growth factor, wherein said tissue retains the natural morphology of untreated tissue and said cells are effective for reducing an immune response of the patient to said tissue upon implant.
Claim 5
Dependent Claim
68 words
An implantable bodily tissue which has been harvested from a donor and subsequently treated with a fibroblast growth factor and populated with fibroblast cells in an amount and for a time period effective for rendering the tissue substantially non-immunogenic upon implant into a mammal said tissue retaining the natural morphology of untreated tissue and said cells effective for reducing the immune response of the tissue in the patient.
Claim 6
Dependent Claim
68 words
An implantable bodily tissue which has been harvested from a donor and subsequently treated with a fibroblast growth factor and populated with fibroblast cells in an amount and for a time period effective for rendering the tissue substantially non-immunogenic upon implant into a mammal said tissue retaining the natural morphology of untreated tissue and said cells effective for reducing the immune response of the tissue in the patient.
Claim 7
Dependent Claim
15 words
The tissue of claim 1, 2 or 3 which is implantable allogeneic or xenogeneic tissue.
Claim 8
Dependent Claim
14 words
The tissue of claim 1 or 2 further comprising a non-human mammalian heart valve.
Claim 9
Dependent Claim
17 words
The tissue of claim 5 wherein the non-human mammalian heart valve is porcine or bovine in origin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-01-25 | 2002-07-27 | 2003-01-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-01-25 | 2006-07-27 | 2007-01-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-01-25 | 2010-07-27 | 2011-01-26 | $7700.00 | Window Closed / Lapsed |