US4402697A
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Method for inhibiting mineralization of natural tissue during implantation
Assignee: Medtronic Inc
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Filing: 1982-08-25
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Granted: 1983-09-06
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Expires: 2002-08-25
Abstract
Abstract Natural tissues fixed with a tanning solution such as glutaraldehyde and intended for implantation in humans, e.g., porcine heart valve prosthetic devices, are treated with a solution of a water soluble phosphate ester such as sodium dodecyl hydrogen phosphate to inhibit mineralization, particularly calcification, of the tissue after implantation.
Inventors
- 👤 Elisabeth M. Pollock
- 👤 David J. Lentz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:03
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
62 words
A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble phosphate ester having the formula ##STR4## wherein at least one of R 1 , R 2 and R 3 is an alkyl group having from 7 to 15 carbon atoms.
Claim 2
Independent Claim
62 words
A method for inhibiting the mineralization of fixed natural tissue after implantation in a living body comprising contacting fixed natural tissue intended for implantation with an aqueous solution of a water soluble phosphate ester having the formula ##STR4## wherein at least one of R 1 , R 2 and R 3 is an alkyl group having from 7 to 15 carbon atoms.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the pH of the aqueous solution ranges from about 2 to about 10.
Claim 4
Dependent Claim
28 words
The method of claim 1 wherein said phosphate ester is a monoalkyl ester and said alkyl group is selected from the group consisting of decyl, dodecyl and myristyl.
Claim 5
Dependent Claim
15 words
The method of claim 1 wherein the alkyl group is a straight chain aliphatic group.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein the alkyl group is a branched aliphatic group.
Claim 7
Dependent Claim
38 words
The method of claim 1 wherein R 1 is an alkyl group having from 7 to 15 carbons, R 2 is hydrogen, and R 3 is selected from the group consisting of sodium, potassium, ammonium and organic amine.
Claim 8
Dependent Claim
20 words
The method of claim 6 wherein said alkyl group is selected from the group consisting of decyl, dodecyl and myristyl.
Claim 9
Dependent Claim
13 words
The method of claim 6 wherein said alkyl group is a dodecyl group.
Claim 10
Dependent Claim
28 words
The method of claim 1 wherein said natural tissue is contacted with said solution for a time sufficient to effectively inhibit future calcification of said tissue after implant.
Claim 11
Dependent Claim
25 words
The method of claim 1 wherein said natural tissue is contacted with said solution for a period of at least 24 hours at ambient temperature.
Claim 12
Dependent Claim
23 words
The method of claim 1 wherein the concentration of said phosphate ester in said solution is from about 0.1 to 5% by weight.
Claim 13
Dependent Claim
18 words
The method of claim 11 wherein the solution has a pH of from about 2 to about 10.
Claim 14
Dependent Claim
52 words
The method of claim 11 wherein said solution comprises, in addition to said phosphate ester, up to about 1% by weight of sodium chloride, up to about 0.05% by weight each of potassium chloride, magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and up to about 0.1% by weight of sodium dihydrogen phosphate.
Claim 15
Dependent Claim
51 words
The method of claim 11 wherein said solution comprises, in addition to said phosphate ester, about 0.8% by weight of sodium chloride, about 0.04% by weight of potassium chloride, about 0.02% by weight each of magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and about 0.08% by weight of sodium dihydrogen phosphate.
Claim 16
Dependent Claim
14 words
The method of claim 14 wherein the pH of said solution is about 3.
Claim 17
Independent Claim
46 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising sodium dodecyl hydrogen phosphate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 18
Independent Claim
46 words
A method for inhibiting the calcification of fixed natural tissue after implantation in a living body which comprises contacting fixed tissue intended for implantation with a solution comprising sodium dodecyl hydrogen phosphate for a time sufficient to effectively inhibit future calcification of said tissue after implantation.
Claim 19
Dependent Claim
20 words
The method of claim 16 wherein said solution comprises from about 0.1 to 5% by weight sodium dodecyl hydrogen phosphate.
Claim 20
Dependent Claim
22 words
The method of claim 16 wherein said tissue is contacted with said solution for a time of at least about 7 days.
Claim 21
Dependent Claim
18 words
The method of claim 16 wherein the pH of said solution ranges from about 2 to about 10.
Claim 22
Dependent Claim
16 words
The method of claim 19 wherein the concentration of sodium dodecyl hydrogen phosphate is about 1%.
Claim 23
Dependent Claim
28 words
The method of claim 19 wherein the tissue is contacted with said solution of sodium dodecyl hydrogen phosphate for a period of about 7 days at ambient temperature.
Claim 24
Dependent Claim
53 words
The method of claim 16 wherein said solution includes, in addition to sodium dodecyl hydrogen phosphate, up to about 1% by weight of sodium chloride, up to about 0.05% by weight each of potassium chloride, magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and up to about 0.1% by weight of sodium dihydrogen phosphate.
Claim 25
Dependent Claim
48 words
The method of claim 16 wherein said solution includes, in addition to sodium dodecyl hydrogen phosphate, about 0.8% by weight sodium chloride, about 0.04% potassium chloride, about 0.02% by weight each of magnesium sulfate heptahydrate and dipotassium hydrogen phosphate, and about 0.08% by weight of sodium dihydrogen phosphate.
Claim 26
Dependent Claim
14 words
The method of claim 23 wherein the pH of said solution is about 3.
Claim 27
Dependent Claim
15 words
The method of claim 16 wherein the fixed tissue is a glutaraldehyde-fixed porcine heart valve.
Claim 28
Dependent Claim
12 words
The method of claim 16 wherein said living body is a human.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-05 | 1987-03-07 | 1987-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-05 | 1991-03-07 | 1991-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-05 | 1995-03-07 | 1995-09-06 | $7700.00 | Window Closed / Lapsed |