US5215541A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Surfactant treatment of implantable biological tissue to inhibit calcification
Assignee: Edwards Lifesciences Corp
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Filing: 1985-03-18
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Granted: 1993-06-01
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Expires: 2005-03-18
Abstract
Abstract A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the treatment of tissue with an effective amount of a surfactant to reduce calcification of the implanted tissue.
Inventors
- 👤 Aws S. Nashef
- 👤 Ahmed I. Ahmed
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:43
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61L27/50; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/922
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
97 words
A method for reducing calcification of biological tissue after implantation in an animal comprising: fixing the biological tissue under tissue fixing conditions; and contacting the biological tissue with a solution of an anionic surfactant prior to implantation in an amount effective in reducing calcification of the tissue after implantation; wherein the surfactant is selected from the group consisting of ethylene oxide sulfates of aliphatic alcohols, sulfates of alkylphenols, alkane sulfonic acids, alkylaryl sulfonic acids, salts of bile acids, salts of fatty acids, N-alkanoyl amino acids, N-acylated amino acids, sulfated ethanol amides, sulfated alkylphenol ethers, and salts thereof.
Claim 2
Independent Claim
97 words
A method for reducing calcification of biological tissue after implantation in an animal comprising: fixing the biological tissue under tissue fixing conditions; and contacting the biological tissue with a solution of an anionic surfactant prior to implantation in an amount effective in reducing calcification of the tissue after implantation; wherein the surfactant is selected from the group consisting of ethylene oxide sulfates of aliphatic alcohols, sulfates of alkylphenols, alkane sulfonic acids, alkylaryl sulfonic acids, salts of bile acids, salts of fatty acids, N-alkanoyl amino acids, N-acylated amino acids, sulfated ethanol amides, sulfated alkylphenol ethers, and salts thereof.
Claim 3
Dependent Claim
15 words
The process of claim 1 wherein the surfactant is the sodium, potassium or ammonium salt.
Claim 4
Dependent Claim
15 words
The process of claim 1 wherein the tissue is contacted with the surfactant during fixation.
Claim 5
Dependent Claim
16 words
The process of claim 1 wherein the tissue is contacted with the surfactant during post-fixation sterilization.
Claim 6
Dependent Claim
22 words
The process of claim 1 wherein the amount of surfactant in the solution is from about 0.1 to about 10 weight percent.
Claim 7
Dependent Claim
24 words
The process of claim 5 wherein the tissue is contacted with the surfactant solution for a time from about 2 to about 30 hours.
Claim 8
Dependent Claim
21 words
The process of claim 1 wherein the amount of surfactant in the solution is from 0.5 to about 5 weight percent.
Claim 9
Dependent Claim
12 words
The process of claim 1 wherein the tissue is fixed with glutaraldehyde.
Claim 10
Dependent Claim
51 words
The process of claim 1 wherein the tissue is fixed with glutaraldehyde; and is contacted with a solution having from about 0.1 to about 10 weight percent of surfactant selected from the group consisting of ethylene oxide sulfates of aliphatic alcohols, sulfates of alkylphenols, alkane sulfonic acids and alkylaryl sulfonic acids.
Claim 11
Dependent Claim
18 words
The process of claim 1 wherein the biological tissue is tendon, ligament, heart valve, dura mater, or pericardium.
Claim 12
Dependent Claim
72 words
The process of claim 1 wherein the amount of surfactant in the solution is from about 0.1 to about 1.5 weight percent; the biological tissue is tendon, ligament, heart valve, dura mater, or pericardium, and is fixed with glutaraldehyde; the surfactant is N-lauroylsarcosine; and the tissue is contacted with the surfactant solution for a time from about 6 to about 24 hours at a pH of from about 7.0 to about 7.6.
Claim 13
Dependent Claim
29 words
The process of claim 1 wherein the tissue is contacted with surfactant during post-fixation sterilization and the surfactant solution further comprises from about 4 to about 5 percent formaldehyde.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-31 | 1996-11-30 | 1997-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-31 | 2000-11-30 | 2001-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-31 | 2004-11-30 | 2005-06-01 | $7700.00 | Window Closed / Lapsed |