US5817046A — Apparatus and method for isolated pelvic perfusion

Claim 1

Independent Claim 158 words

Apparatus for isolated perfusion of the pelvic cavity of a patient comprising: a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient.

Claim 2

Dependent Claim 158 words

Apparatus for isolated perfusion of the pelvic cavity of a patient comprising: a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient.

Claim 3

Dependent Claim 193 words

The apparatus of claim 1, wherein said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein; fenestration in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube; said second lumen connecting to one of said balloons; and, said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; and, a return catheter for returning blood removed through said main lumen to the patient.

Claim 4

Dependent Claim 20 words

The apparatus of claim 2 wherein said plastic tube has a fourth lumen sized to accommodate an angiographic guide wire.

Claim 5

Dependent Claim 21 words

The apparatus of claim 2 wherein said second and third lumina connect and are common to the interiors of said balloons.

Claim 6

Dependent Claim 19 words

The apparatus of claim 2 wherein said second and third lumina lie within the wall of said plastic tube.

Claim 7

Dependent Claim 337 words

A kit comprising: a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; wherein said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein; fenestration in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube; said second lumen connecting to one of said balloons; and, said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; and, a return catheter for returning blood removed through said main lumen to the patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient.

Claim 8

Dependent Claim 337 words

A kit comprising: a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; wherein said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein; fenestration in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube; said second lumen connecting to one of said balloons; and, said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; and, a return catheter for returning blood removed through said main lumen to the patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient.

Claim 9

Dependent Claim 27 words

The kit of claim 6 wherein the detoxification device includes a device selected from the group consisting of devices designed to provide hemoperfusion, hemodialysis, hemofiltration and hemoabsorption.

Claim 10

Dependent Claim 59 words

The kit of claim 6 wherein said second catheter is designed to fit within said plastic tube and said cranial end tapers are designed to fit thereabout such that the treated blood is returned past the cranial balloon and said kit includes arterial injection means for introducing said treating agent into a common iliac vein leading to said tumor.

Claim 11

Dependent Claim 13 words

The kit of claim 6 wherein said treating agent is an anti-cancer agent.

Claim 12

Dependent Claim 25 words

The kit of claim 6 further including an angiographic guide wire, wherein said cranial end is tapered to a diameter of an angiographic guide wire.

Claim 13

Independent Claim 249 words

A method for isolated pelvic perfusion comprising the steps of: providing a kit which includes a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient; occluding said aorta with said first catheter; occluding said vena cava with said second catheter; occluding said common iliac vein with said third catheter; occluding said common iliac artery with said fourth catheter; restricting said flow of blood with said bilateral thigh tourniquets; perfusing chemotherapeutic agents into the pelvic cavity through said first and second catheters; withdrawing toxified blood from said pelvic cavity through said third catheter; detoxifying said toxified blood with said detoxification device to provide detoxified blood; and, reinfusing said detoxified blood through said fourth catheter.

Claim 14

Independent Claim 249 words

A method for isolated pelvic perfusion comprising the steps of: providing a kit which includes a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient; occluding said aorta with said first catheter; occluding said vena cava with said second catheter; occluding said common iliac vein with said third catheter; occluding said common iliac artery with said fourth catheter; restricting said flow of blood with said bilateral thigh tourniquets; perfusing chemotherapeutic agents into the pelvic cavity through said first and second catheters; withdrawing toxified blood from said pelvic cavity through said third catheter; detoxifying said toxified blood with said detoxification device to provide detoxified blood; and, reinfusing said detoxified blood through said fourth catheter.

Claim 15

Dependent Claim 357 words

Apparatus for isolated perfusion of the pelvic cavity of a patient comprising: a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient; said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein; fenestration in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube; said second lumen connecting to one of said balloons; and, said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; a return catheter for returning blood removed through said main lumen to the patient; and said cranial end is tapered to a diameter of an angiographic guide wire.

Claim 16

Dependent Claim 357 words

Apparatus for isolated perfusion of the pelvic cavity of a patient comprising: a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient; said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein; fenestration in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube; said second lumen connecting to one of said balloons; and, said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; a return catheter for returning blood removed through said main lumen to the patient; and said cranial end is tapered to a diameter of an angiographic guide wire.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2001-10-05	2002-04-06	2002-10-06	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2005-10-05	2006-04-06	2006-10-06	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2009-10-05	2010-04-06	2010-10-06	$7700.00	Window Closed / Lapsed

Apparatus and method for isolated pelvic perfusion

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