US4708718A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hyperthermic treatment of tumors
Assignee: Stryker European Operations Holdings LLC
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Filing: 1985-07-02
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Granted: 1987-11-24
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Expires: 2005-07-02
Abstract
Abstract A method of treating a solid tumor, including the steps of localizing the tumor and the arterial vessel that supplies it, and injecting into the vessel, a vaso-occlusive collagen material adapted to produce occlusion of vessels having lumen diameters between about 10 and 150 microns. The injected material is effective to produce occlusion of the secondary and tertiary vessels supplying the tumor, distal to the collateral blood vessels which may also supply the tumor. The region of the occluded tumor is heated under conditions that produce tissue necrosis selectively in the occluded tumor tissue.
Inventors
- 👤 John R. Daniels
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:22
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/102; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K; A61K38/00; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
93 words
A method of treating a solid tumor comprising: a. localizing the tumor and the arterial vessel that supplies it, b. providing a collagen vaso-occlusive material adapted to produce occlusion of blood vessels having lumen diameters between about 10 and 150 microns, c. injecting said material into said arterial vessel, d. by said injecting, producing vaso-occlusion of the secondary and tertiary vessels supplying the tumor, distal to the collateral blood vessels which may also supply the tumor, and e. heating the tumor under conditions which produce tissue necrosis selectively in the occluded tumor tissue.
Claim 2
Independent Claim
93 words
A method of treating a solid tumor comprising: a. localizing the tumor and the arterial vessel that supplies it, b. providing a collagen vaso-occlusive material adapted to produce occlusion of blood vessels having lumen diameters between about 10 and 150 microns, c. injecting said material into said arterial vessel, d. by said injecting, producing vaso-occlusion of the secondary and tertiary vessels supplying the tumor, distal to the collateral blood vessels which may also supply the tumor, and e. heating the tumor under conditions which produce tissue necrosis selectively in the occluded tumor tissue.
Claim 3
Dependent Claim
25 words
The method of claim 1, wherein said heating is effective to raise the temperature of the occluded tumor tissue to at least about 42° C.
Claim 4
Dependent Claim
26 words
The method of claim 1, wherein said heating is effective in raising the temperature of the occluded tumor tissue to between about 44° and 46° C.
Claim 5
Dependent Claim
31 words
The method of claim 1, wherein said heating is effective to produce a temperature differential between the occluded tumor tissue and the adjacent, non-occluded tissue of at least about 2° C.
Claim 6
Dependent Claim
34 words
The method of claim 4, wherein said heating is applied for a period calculated to produce at least about four times more tissue necrosis in the occluded tumor tissue than in adjacent, non-occluded tissue.
Claim 7
Dependent Claim
35 words
The method of claim 5, wherein said heating is effective to raise the tumor temperature to at least about 44° C., and said heating is applied for a period of at least about 30 minutes.
Claim 8
Dependent Claim
40 words
The method of claim 1, wherein the collagen material includes a suspension of chemically cross-linked atelopeptide collagen which is adapted to persist in such secondary and tertiary vessels, after said injecting, for a period of at least about two weeks.
Claim 9
Dependent Claim
18 words
The method of claim 7, which further includes repeating said heating step during the period of vaso-occlusive persistence.
Claim 10
Dependent Claim
30 words
The method of claim 7, wherein the collagen material is cross-linked under conditions which produce predominantly intrafibrillar cross-links, and the period of vaso-occlusive persistence is less than about two months.
Claim 11
Dependent Claim
20 words
The method of claim 9, wherein the collagen material is cross-linked by reacting enzyme-solubilized collagen atelopeptide with about 0.005%-0.1% glutaraldehyde.
Claim 12
Dependent Claim
25 words
The method of claim 7, wherein the collagen material is cross-linked under conditions which produce interfibrillar cross-links, and vaso-occlusion persists for up to two months.
Claim 13
Dependent Claim
20 words
The method of claim 11, wherein the collagen material is cross-linked by reacting enzyme-solubilized collagen atelopeptide with about 0.1%-2.5% glutaraldehyde.
Claim 14
Dependent Claim
24 words
The method of claim 7, wherein the collagen material includes a radio-opaque agent which permits the area of vaso-occlusion to be visualized by fluoroscopy.
Claim 15
Dependent Claim
45 words
The method of claim 1, wherein the tumor receives its blood supply from along a segment of such vessel, and said injecting includes blocking the distal end of such segment and delivering the collagen material to the vessel just proximal to such blocked distal end.
Claim 16
Dependent Claim
19 words
The method of claim 14, which further includes blocking the proximal end of such segment prior to said delivering.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-23 | 1991-05-25 | 1991-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-23 | 1995-05-25 | 1995-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-23 | 1999-05-25 | 1999-11-24 | $7700.00 | Window Closed / Lapsed |