US4059512A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for removing endotoxin from biological fluids
Assignee: Akzona Inc
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Filing: 1975-12-16
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Granted: 1977-11-22
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Expires: 1995-12-16
Abstract
Abstract A novel process for removing endotoxin from biological fluids such as parenteral fluids and for removing or reducing the level of endotoxin from the blood of animals is disclosed. The novel process includes the utilization of certain non-ionogenic hydrophobic synthetic plastic polymers that have been found to be capable of adsorbing endotoxin from the biological fluids when placed in intimate contact therewith.
Inventors
- 👤 Nick S. Harris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:23
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
109 words
A process for selectively removing endotoxin derived from gram-negative bacilli from biological fluids, said process comprising: passing a biological fluid contaminated with gram-negative bacilli derived endotoxin through a microporous film, having an effective pore size of from about 0.04 to about 0.5 micrometers, of a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline, non-polar aliphatic hydrocarbon thermoplastic polymer, a substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer, a cross-linked aliphatic silicone elastomeric polymer and mixtures thereof, whereby the endotoxin is adsorbed onto the surface of the polymer; and removing the biological fluid from contact with said polymer essentially free of said endotoxin.
Claim 2
Dependent Claim
109 words
A process for selectively removing endotoxin derived from gram-negative bacilli from biological fluids, said process comprising: passing a biological fluid contaminated with gram-negative bacilli derived endotoxin through a microporous film, having an effective pore size of from about 0.04 to about 0.5 micrometers, of a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline, non-polar aliphatic hydrocarbon thermoplastic polymer, a substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer, a cross-linked aliphatic silicone elastomeric polymer and mixtures thereof, whereby the endotoxin is adsorbed onto the surface of the polymer; and removing the biological fluid from contact with said polymer essentially free of said endotoxin.
Claim 3
Dependent Claim
29 words
The process of claim 1 wherein the microporous film is a microporous polypropylene film having an effective pore size of about 0.04 micrometers and a porosity of about 45%.
Claim 4
Dependent Claim
29 words
The process of claim 1 wherein the microporous film is a microporous polyethylene film having an effective pore size of about 0.50 micrometers and a porosity of about 65%.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-21 | 1981-05-23 | 1981-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-21 | 1985-05-23 | 1985-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-21 | 1989-05-23 | 1989-11-22 | $7700.00 | Window Closed / Lapsed |