US4883459A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Retrograde perfusion
Assignee: Individual
•
Filing: 1987-12-21
•
Granted: 1989-11-28
•
Expires: 2007-12-21
Abstract
Abstract Tumors in the body of a patient are studied in situ by a monitor, such as computer assisted tomography, X-ray or the like, while optimal flow paths through the tumor area are established. A catheter with a suction lumen and an infusion lumen, with seals associated with each, is placed in the patient's vein near the tumor. Flow is then sealed in the vein with the infusion seal. A carrier medium dye is injected into the tumor at selected flow rates and differential pressures. Flow of the dye through the tumor is observed on the monitor to determine optimal retrograde perfusion paths through the tumor for the selected flow rates and differential pressures. Once the optimal perfusion paths are noted, a preferential attack area in the tumor is located using a different, less dense carrier dye and increased fluid back pressure in the infusion system. Once the attack area in the tumor is located, microspheres with active ingredients, such as chemotherapy, can be selectively perfused through one of the paths in the tumor to the attack site and forced into the tumor, once at the attack site, using increased back pressure. The process may be cyclically repeated using the same or different active ingredients. The procedure may be repeated through the tumor in different paths and attack points at desired active ingredient dosages using increased back pressures.
Inventors
- 👤 Reynaldo Calderon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:41
CPC Classifications
A; A61; A61M; A61M25/00; A61M1/00; A61M1/36; A61M1/3613; A61M1/3615; A61M1/71; A61M1/77; A61M1/84; A61M1/85; A61M25/0021; A61M25/0023; A61M25/0026; A61M25/10; A61M25/1011; A61M2025/1015
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
314 words
An apparatus for treating a tumor in the body of a patient with an active ingredient, comprising: (a) a catheter means for location in a vein of the patient near the tumor, said catheter means comprising: (1) a suction lumen for removing fluids; and (2) an infusion lumen extending beyond said suction lumen for passing fluids into the tumor; (b) infusion seal means on said catheter means between said infusion lumen and said suction lumen for sealing the patient's vein; (c) suction seal means on said catheter means for sealing the flow of fluid in the patient's vein past said suction lumen; (d) a source of carrier medium and a flow path injector means for injecting said carrier medium into the tumor from said infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (e) said flow path means further comprising means for establishing a steady state flow rate and pressure in a selected one of the flow paths; (f) a source of a less dense carrier medium and a means for introducing said less dense carrier medium through said infusion lumen; (g) means for selectively increasing back pressure on the fluids in the tumor to determine a preferred target area in the tumor where said less dense carrier medium is driven into interstitial spaces in the tumor; (h) a source of a first fluid and an active ingredient and a treatment injector means for injecting said first fluid and thereafter said active ingredient into the patient's vein from said infusion lumen; (i) said means for selectively increasing back pressure further comprising means for increasing back pressure on said first fluid and active ingredient in the patient's vein when said active ingredient is at the preferred target area; and (j) means for collecting said first fluid and active ingredient from said suction lumen after perfusion through the tumor.
Claim 2
Independent Claim
314 words
An apparatus for treating a tumor in the body of a patient with an active ingredient, comprising: (a) a catheter means for location in a vein of the patient near the tumor, said catheter means comprising: (1) a suction lumen for removing fluids; and (2) an infusion lumen extending beyond said suction lumen for passing fluids into the tumor; (b) infusion seal means on said catheter means between said infusion lumen and said suction lumen for sealing the patient's vein; (c) suction seal means on said catheter means for sealing the flow of fluid in the patient's vein past said suction lumen; (d) a source of carrier medium and a flow path injector means for injecting said carrier medium into the tumor from said infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (e) said flow path means further comprising means for establishing a steady state flow rate and pressure in a selected one of the flow paths; (f) a source of a less dense carrier medium and a means for introducing said less dense carrier medium through said infusion lumen; (g) means for selectively increasing back pressure on the fluids in the tumor to determine a preferred target area in the tumor where said less dense carrier medium is driven into interstitial spaces in the tumor; (h) a source of a first fluid and an active ingredient and a treatment injector means for injecting said first fluid and thereafter said active ingredient into the patient's vein from said infusion lumen; (i) said means for selectively increasing back pressure further comprising means for increasing back pressure on said first fluid and active ingredient in the patient's vein when said active ingredient is at the preferred target area; and (j) means for collecting said first fluid and active ingredient from said suction lumen after perfusion through the tumor.
Claim 3
Dependent Claim
43 words
The apparatus of claim 1, wherein said treatment injector means further comprises: means for selectively injecting different active ingredients into the patient's vein from said infusion lumen so that the different active ingredients may perfuse through the tumor from the preferred target area.
Claim 4
Dependent Claim
26 words
The apparatus of claim 1, further including: heat sensor means for detecting temperature conditions near the tumor in the patient to monitor treatment of the patient.
Claim 5
Dependent Claim
31 words
The apparatus of claim 1, further including: heat sensor means for detecting temperature conditions at the preferred target area in the tumor in the patient to monitor treatment of the patient.
Claim 6
Independent Claim
299 words
A method for treating a tumor in the body of a patient with an active ingredient, comprising the steps of: (a) placing a catheter having a suction lumen and an infusion lumen extending beyond the suction lumen and an infusion seal associated with the infusion lumen and a suction seal associated with the suction lumen in a vein of the patient near the tumor; (b) sealing the flow of fluid in the patient's vein between the infusion lumen and the suction lumen with the infusion seal; (c) injecting a carrier medium into the tumor from the infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (d) sealing the flow of fluid in the patient's vein past the suction lumen with the suction seal; (e) injecting a carrier medium from the infusion lumen in a selected one of the established flow paths at a desired flow rate and pressure until steady state flow is established; (f) injecting a second, less dense carrier medium from the infusion lumen in the selected one of the established flow paths; (g) increasing the back pressure on the carrier medium when the second carrier medium is in the tumor to force the second carrier medium into interstitial spaces in the tumor at an attack site; (h) injecting an active ingredient behind a carrier fluid into the patient's vein from the infusion lumen along the established flow path; (i) increasing the back pressure on the carrier fluid and active ingredient when the active ingredient is at the attack site to force the active ingredient into interstitial spaces in the tumor so that the active ingredient is driven into the interstitial spaces in the tumor; and (j) collecting the active ingredient in the suction lumen after perfusion through the tumor.
Claim 7
Independent Claim
299 words
A method for treating a tumor in the body of a patient with an active ingredient, comprising the steps of: (a) placing a catheter having a suction lumen and an infusion lumen extending beyond the suction lumen and an infusion seal associated with the infusion lumen and a suction seal associated with the suction lumen in a vein of the patient near the tumor; (b) sealing the flow of fluid in the patient's vein between the infusion lumen and the suction lumen with the infusion seal; (c) injecting a carrier medium into the tumor from the infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (d) sealing the flow of fluid in the patient's vein past the suction lumen with the suction seal; (e) injecting a carrier medium from the infusion lumen in a selected one of the established flow paths at a desired flow rate and pressure until steady state flow is established; (f) injecting a second, less dense carrier medium from the infusion lumen in the selected one of the established flow paths; (g) increasing the back pressure on the carrier medium when the second carrier medium is in the tumor to force the second carrier medium into interstitial spaces in the tumor at an attack site; (h) injecting an active ingredient behind a carrier fluid into the patient's vein from the infusion lumen along the established flow path; (i) increasing the back pressure on the carrier fluid and active ingredient when the active ingredient is at the attack site to force the active ingredient into interstitial spaces in the tumor so that the active ingredient is driven into the interstitial spaces in the tumor; and (j) collecting the active ingredient in the suction lumen after perfusion through the tumor.
Claim 8
Dependent Claim
30 words
The method of claim 5, further including the steps of: repeating said steps of injecting an active ingredient and increasing the back pressure on the carrier fluid and active ingredient.
Claim 9
Dependent Claim
47 words
The method of claim 5, further including the steps of: (a) selectively injecting different active ingredients behind the carrier fluid; and (b) increasing the back pressure when the different active ingredients are at the attack site so that the different active ingredients are driven into the tumor.
Claim 10
Dependent Claim
190 words
The method of claim 5, further including the steps of: (a) changing the flow rate and pressure of the carrier medium to a new value to establish a different flow path through the tumor; (b) maintaining the flow rate and pressure at the new valve until steady state flow is established in the different flow path; (c) injecting a second, less dense carrier medium from the infusion lumen in the different flow path; (d) increasing the back pressure on the carrier medium when the second carrier medium is in the tumor to force the second carrier medium into interstitial spaces in the tumor at an attack site in the different flow path; (e) injecting an active ingredient behind a carrier fluid into the patient's vein from the infusion lumen along the different flow path; (f) increasing the back pressure on the carrier fluid and active ingredient when the active ingredient is at the attack site to force the active ingredient into interstitial spaces in the different flow path in the tumor so that the active ingredient is driven into the interstitial spaces in the different flow path in the tumor.
Claim 11
Dependent Claim
16 words
The method of claim 5, further including the step of: monitoring temperature conditions in the tumor.
Claim 12
Dependent Claim
78 words
The method of claim 5, further including the steps of: (a) injecting a heated fluid behind the carrier fluid into the patient's vein from the infusion lumen along the established flow path; (b) increasing the back pressure on the carrier fluid and heated fluid when the heated fluid is at the attack site to force the heated fluid into interstitial spaces in the tumor so that the heated fluid is driven into the interstitial spaces in the tumor.
Claim 13
Dependent Claim
20 words
The method of claim 10, further including the step of: monitoring temperature conditions at the attack site in the tumor.
References Cited (Backward Citations)
US2854982A
Cited
US3888239A
Cited
SU651817A1
Cited
US4192302A
Cited
US4445892A
Cited
US4714460A
Cited
US4709703A
Cited
US4908718A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-27 | 1993-05-29 | 1993-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-27 | 1997-05-29 | 1997-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-27 | 2001-05-29 | 2001-11-28 | $7700.00 | Window Closed / Lapsed |