US4867742A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Retrograde perfusion
Assignee: Individual
•
Filing: 1987-08-07
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Granted: 1989-09-19
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Expires: 2007-08-07
Abstract
Abstract Tumors in the body of a patient are studied in situ by a monitor, such as computer assisted tomography, X-ray or the like, while optimal flow paths through the tumor area are established. A catheter with a suction lumen and an infusion lumen, with seals associated with each, is placed in the patient's vein near the tumor. Flow is then sealed in the vein with the infusion seal. A carrier medium dye is injected into the tumor at selected flow rates and differential pressures. Flow of the dye through the tumor is observed on the monitor to determine optimal retrograde perfusion paths through the tumor for the selected flow rates and differential pressures. Once the optimal perfusion paths are noted, microspheres with active ingredients, such as chemotherapy, can be selectively perfused through each of the paths in the tumor at desired flow rates, pressures and active ingredient dosages. Alternatively, microspheres with different active ingredients can be selectively introduced through the tumor in different paths at desired active ingredient dosages and established flow rates and pressures.
Inventors
- 👤 Reynaldo Calderon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:03
CPC Classifications
A; A61; A61M; A61M25/00; A61M1/00; A61M1/36; A61M1/3615; A61M25/0021; A61M25/0023; A61M25/0026; A61M25/10; A61M25/1011; A61M37/00; A61M25/01; A61M25/09; A61M2025/09175; A61M2025/09183; A61M2025/1015
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
213 words
An apparatus for treating a tumor in the body of a patient with an active ingredient, comprising: (a) catheter means for location in a vein of the patient near the tumor, said catheter means comprising: (1) a suction lumen for removing fluids; and (2) an infusion lumen extending beyond said suction lumen for passing fluids into the tumor; (b) infusion seal means on said catheter means between said infusion lumen and said suction lumen for sealing the patient's vein; (c) suction seal means on said catheter means for sealing the flow of fluid in the patient's vein past said suction lumen. (d) a source of carrier medium and a flow path injector means for injecting said carrier medium into the tumor from said infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (e) a source of active ingredient and a treatment injector means for injecting said active ingredient into the patient's vein from said infusion lumen at one of the selected flow rates and pressures so that the active ingredient may perfuse through the tumor along one of the preferential flow paths established by said flow path injector means; and (f) means for collecting the active ingredient from said suction lumen after perfusion through the tumor.
Claim 2
Independent Claim
213 words
An apparatus for treating a tumor in the body of a patient with an active ingredient, comprising: (a) catheter means for location in a vein of the patient near the tumor, said catheter means comprising: (1) a suction lumen for removing fluids; and (2) an infusion lumen extending beyond said suction lumen for passing fluids into the tumor; (b) infusion seal means on said catheter means between said infusion lumen and said suction lumen for sealing the patient's vein; (c) suction seal means on said catheter means for sealing the flow of fluid in the patient's vein past said suction lumen. (d) a source of carrier medium and a flow path injector means for injecting said carrier medium into the tumor from said infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (e) a source of active ingredient and a treatment injector means for injecting said active ingredient into the patient's vein from said infusion lumen at one of the selected flow rates and pressures so that the active ingredient may perfuse through the tumor along one of the preferential flow paths established by said flow path injector means; and (f) means for collecting the active ingredient from said suction lumen after perfusion through the tumor.
Claim 3
Dependent Claim
36 words
The apparatus of claim 1, wherein said treatment means further comprises: means for varying the flow rate and pressure of injection of the active ingredient into the patient's tumor to establish distinct differential flow paths therethrough.
Claim 4
Dependent Claim
44 words
The apparatus of claim 1, wherein said treatment means further comprises: means for selectively injecting different active ingredients into the patient's vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths.
Claim 5
Dependent Claim
47 words
The apparatus of claim 1, wherein said treatment means further comprises: means for selectively injecting different active ingredients into the patient's vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths at different times.
Claim 6
Independent Claim
178 words
A method for treating a tumor in the body of a patient with an active ingredient, comprising the steps of: (a) placing a catheter having a suction lumen, an infusion lumen extending beyond the suction lumen, and an infusion seal between same in a vein of the patient near the tumor; (b) sealing the flow of fluid in the patient's vein between the infusion lumen and the suction lumen with the infusion seal; (c) sealing the flow of a fluid in the patient's vein past the suction lumen with a suction seal; (d) injecting a carrier medium into the tumor from the infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (e) injecting an active ingredient into the patient's vein from the infusion lumen at one of the selected flow rates and pressures so that the active ingredient may perfuse through the tumor along one of the preferential flow paths established during said step of injecting; and (f) collecting the active ingredient in the suction lumen after perfusion through the tumor.
Claim 7
Independent Claim
178 words
A method for treating a tumor in the body of a patient with an active ingredient, comprising the steps of: (a) placing a catheter having a suction lumen, an infusion lumen extending beyond the suction lumen, and an infusion seal between same in a vein of the patient near the tumor; (b) sealing the flow of fluid in the patient's vein between the infusion lumen and the suction lumen with the infusion seal; (c) sealing the flow of a fluid in the patient's vein past the suction lumen with a suction seal; (d) injecting a carrier medium into the tumor from the infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor; (e) injecting an active ingredient into the patient's vein from the infusion lumen at one of the selected flow rates and pressures so that the active ingredient may perfuse through the tumor along one of the preferential flow paths established during said step of injecting; and (f) collecting the active ingredient in the suction lumen after perfusion through the tumor.
Claim 8
Dependent Claim
21 words
The method of claim 5, further including the step of: collecting the injected carrier medium after said step of injecting same.
Claim 9
Dependent Claim
28 words
The method of claim 6, wherein: said step of collecting the carrier medium is performed after said step of sealing the flow of fluid past the suction lumen.
Claim 10
Dependent Claim
22 words
The method of claim 7, wherein: said step of collecting the carrier medium comprises collecting the carrier medium in the suction lumen.
Claim 11
Dependent Claim
40 words
The method of claim 8, further including the step of: moving the suction lumen to different positions in the patient's tumor for each of the selected flow rates and pressures to conform to the flow paths established through the tumor.
Claim 12
Dependent Claim
28 words
The method of claim 6, wherein: said step of collecting the active ingredient is performed after said step of sealing the flow of fluid past the suction lumen.
Claim 13
Dependent Claim
33 words
The method of claim 5, further including the steps of: varying the flow rate and pressure of injection of the active ingredient into the patient's tumor to establish distinct differential flow paths therethrough.
Claim 14
Dependent Claim
41 words
The method of claim 5, further including the steps of: selectively injecting different active ingredients into the patient's vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths.
Claim 15
Dependent Claim
44 words
The method of claim 5, further including the steps of: selectively injecting different active ingredients into the patient's vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths at different times.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-18 | 1993-03-20 | 1993-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-18 | 1997-03-20 | 1997-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-18 | 2001-03-20 | 2001-09-19 | $7700.00 | Window Closed / Lapsed |