US4728432A
Expired / Lapsed
US
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Method for decontaminating blood
Assignee: JMS Co Ltd
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Filing: 1986-05-14
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Granted: 1988-03-01
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Expires: 2006-05-14
Abstract
Abstract A method for decontaminating blood uses an adsorber prepared by forming a porous membrane containing an adsorbent in the form of powder or fine particles on a support is suitable for removing harmful soluble substances contained in blood. The adsorber has a high rate of adsorbtion, and does not readily shed the fine particles of the adsorbent material. In order to attain these features, it is necessary to set the thickness of the porous membrane within a specified range.
Inventors
- 👤 Masafumi Sugiyama
- 👤 Hideki Kawanishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:43
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/28; B01J20/28002; B01J20/28004; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B01D; B01D15/00; B01D61/00; B01D69/00; B01D69/10; B01D69/106; B01D69/107; B01D69/1071; B01D69/108; B01J20/28014; B01J20/28026; B01J20/28033; B01J20/28052; B01D2311/00; B01D2311/26; B01D2311/2626
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
68 words
A method for removing soluble poisonous substances contained in blood by hemoperfusion comprising providing a support; attaching a porous membrane to said support, said membrane having a thickness in the range of approximately 10-400 microns and containing a powdery or fine particulate adsorbent for removing soluble poisonous substances from blood; and bringing blood into contact with said adsorbent-containing membrane, thereby effectively removing said poisonous substances from said blood.
Claim 2
Independent Claim
68 words
A method for removing soluble poisonous substances contained in blood by hemoperfusion comprising providing a support; attaching a porous membrane to said support, said membrane having a thickness in the range of approximately 10-400 microns and containing a powdery or fine particulate adsorbent for removing soluble poisonous substances from blood; and bringing blood into contact with said adsorbent-containing membrane, thereby effectively removing said poisonous substances from said blood.
Claim 3
Dependent Claim
41 words
The method of claim 1 further comprising the steps of: placing said adsorbent containing porous membrane and support in a housing containing a blood inlet and a blood outlet; and passing blood through said housing via said blood inlet and outlet.
Claim 4
Dependent Claim
20 words
The method of claim 1 wherein said adsorbent has an average particle diameter ranging from about 10 to 100 microns.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said adsorbent is activated carbon.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein said adsorbent is a porous organic resin.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein said adsorbent is porous alumina.
Claim 8
Dependent Claim
11 words
The method of claim 1 whrein said adsorbent is porous silica.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein said adsorbent is porous glass.
Claim 10
Dependent Claim
10 words
The method of claim 1 wherein said adsorbent comprises polyurethane.
Claim 11
Dependent Claim
21 words
The method of claim 1 wherein the porous membrane contains the adsorbent in the range of from 30 to 70 wt%.
Claim 12
Independent Claim
87 words
A method for removing soluble poisonous substances contained in blood by hemoperfusion comprising the steps of providing a porous membrane having a thickness in the range of approximately 10-400 microns and containing a powder or fine particulate adsorbent for removing soluble poisonous substances from blood; wrapping said membrane about a core; placing said core in a housing having a blood inlet and a blood outlet; and passing blood through said housing via said blood inlet and outlet and thereby effectively removing said poisonous substances from said blood.
Claim 13
Independent Claim
87 words
A method for removing soluble poisonous substances contained in blood by hemoperfusion comprising the steps of providing a porous membrane having a thickness in the range of approximately 10-400 microns and containing a powder or fine particulate adsorbent for removing soluble poisonous substances from blood; wrapping said membrane about a core; placing said core in a housing having a blood inlet and a blood outlet; and passing blood through said housing via said blood inlet and outlet and thereby effectively removing said poisonous substances from said blood.
Claim 14
Dependent Claim
48 words
The method of claim 11 further comprising the steps of: seating annular elastomeric end panels having a porous structure on said core adjacent the opposed ends of said membrane; and seating annular supports on said core between the elastomeric end panels and the blood inlet and blood outlet.
Claim 15
Independent Claim
72 words
A method for removing soluble poisonous substances contained in blood by hemoperfusion comprising the steps of: preparing an adsorbent membrane having a thickness in the range of approximately 10-400 microns by applying a polymer solution contining an adsorbent dispersed therein to a support, then subsequently contacting the applied solution with a nonsolvent for said polymer; and bringing blood into contact with said absorber thereby effectively removing said poisonous substances from said blood.
Claim 16
Independent Claim
72 words
A method for removing soluble poisonous substances contained in blood by hemoperfusion comprising the steps of: preparing an adsorbent membrane having a thickness in the range of approximately 10-400 microns by applying a polymer solution contining an adsorbent dispersed therein to a support, then subsequently contacting the applied solution with a nonsolvent for said polymer; and bringing blood into contact with said absorber thereby effectively removing said poisonous substances from said blood.
Claim 17
Dependent Claim
13 words
The method of claim 13 wherein the nonsolvent for said polymer is water.
Claim 18
Independent Claim
63 words
A method for removing bilirubin contained in blood by hemoperfusion comprising providing a support; attaching a porous membrane to said support, said membrane having a thickness in the range of approximately 10-400 microns and containing a powdery or fine particulate adsorbent for removing bilirubin from blood; and bringing blood into contact with said adsorbent-containing membrane, thereby effectively removing said bilirubin from said blood.
Claim 19
Independent Claim
63 words
A method for removing bilirubin contained in blood by hemoperfusion comprising providing a support; attaching a porous membrane to said support, said membrane having a thickness in the range of approximately 10-400 microns and containing a powdery or fine particulate adsorbent for removing bilirubin from blood; and bringing blood into contact with said adsorbent-containing membrane, thereby effectively removing said bilirubin from said blood.
Claim 20
Independent Claim
82 words
A method for removing bilirubin contained in blood by hemoperfusion comprising the steps of: providing a porous membrane having a thickness in the range of approximately 10-400 microns and containing a powdery or fine particulate adsorbent for removing bilirubin from blood; wrapping said membrane about a core; placing said core in a housing having a blood inlet and a blood outlet; and passing blood through said housing via said blood inlet and outlet and thereby effectively removing said billirubin from said blood.
Claim 21
Independent Claim
82 words
A method for removing bilirubin contained in blood by hemoperfusion comprising the steps of: providing a porous membrane having a thickness in the range of approximately 10-400 microns and containing a powdery or fine particulate adsorbent for removing bilirubin from blood; wrapping said membrane about a core; placing said core in a housing having a blood inlet and a blood outlet; and passing blood through said housing via said blood inlet and outlet and thereby effectively removing said billirubin from said blood.
Claim 22
Independent Claim
69 words
A method for removing bilirubin contained in blood by hemoperfusion comprising the steps of: preparing an adsorbent membrane having a thickness in the range of approximately 10-400 microns by applying a polymer solution containing an adsorbent dispersed therein in a support, then subsequently contacting the applied solution with a nonsolvent for said polymer; and bringing blood into contact with said adsorber thereby effectively removing said bilirubin from said blood.
Claim 23
Independent Claim
69 words
A method for removing bilirubin contained in blood by hemoperfusion comprising the steps of: preparing an adsorbent membrane having a thickness in the range of approximately 10-400 microns by applying a polymer solution containing an adsorbent dispersed therein in a support, then subsequently contacting the applied solution with a nonsolvent for said polymer; and bringing blood into contact with said adsorber thereby effectively removing said bilirubin from said blood.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-01 | 1991-08-31 | 1992-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-01 | 1995-08-31 | 1996-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-01 | 1999-08-31 | 2000-03-01 | $7700.00 | Window Closed / Lapsed |