US5451424A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-infective and antithrombogenic medical articles and method for their preparation
Assignee: Becton Dickinson and Co
•
Filing: 1992-11-24
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Granted: 1995-09-19
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Expires: 2012-11-24
Abstract
Abstract An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
Inventors
- 👤 Donald D. Solomon
- 👤 M. Parke Byron
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:41
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/04; A61L29/06; A61L29/08; A61L29/085; A61L29/14; A61L29/16; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/204; A61L2300/206; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/45; A61M; A61M25/00; A61M25/0043; A61M2025/0056
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
91 words
A method for preparing a medical article comprising: a) preparing a blend of an anti-infective agent comprising chlorhexide, with pellets of a base polymer having a water absorption of at least 0.6% by weight; b) heating said blend to a temperature from about 160° C. to about 250° C. and for a sufficient time to form a homogenous melt of said polymer having said anti-infective agent uniformly distributed therein; and c) extruding said melt through a die to form a medical article having said anti-infective agent bulk distributed throughout said polymer.
Claim 2
Independent Claim
91 words
A method for preparing a medical article comprising: a) preparing a blend of an anti-infective agent comprising chlorhexide, with pellets of a base polymer having a water absorption of at least 0.6% by weight; b) heating said blend to a temperature from about 160° C. to about 250° C. and for a sufficient time to form a homogenous melt of said polymer having said anti-infective agent uniformly distributed therein; and c) extruding said melt through a die to form a medical article having said anti-infective agent bulk distributed throughout said polymer.
Claim 3
Dependent Claim
37 words
The method of claim 1 further comprising applying to a surface of said article a coating of an agent selected from the group consisting of anti-infective agent comprising chlorhexidine, a surface active agent and an antithrombogenic agent.
Claim 4
Dependent Claim
23 words
The method in accordance with claim 2 wherein said applying step is performed by steeping said article in a solution of said agent.
Claim 5
Dependent Claim
30 words
The method in accordance with claim 2 further comprising ionically bonding an agent selected from the group consisting of an antibiotic and an antithrombogenic agent to said surface active agent.
Claim 6
Dependent Claim
39 words
The method of claim 1 further comprising coating the article with a layer of laminating polymer having a water absorption of at least 0.6% by weight and anti-infective agent comprising chlorhexidine bulk distributed therein to give a coated article.
Claim 7
Dependent Claim
24 words
The method of claim 5 wherein said coating step is performed by steeping the article in a solution of said laminating polymer and chlorhexidine.
Claim 8
Dependent Claim
40 words
The method of claim 5 further comprising applying a surface active agent to the surface of said coated article and reacting the surface active agent with a reagent selected from the group consisting of an antibiotic and an antithrombogenic agent.
Claim 9
Dependent Claim
23 words
The method in accordance with claim 1 wherein said chlorhexidine is selected from the group consisting of chlorhexidine base and a salt thereof.
Claim 10
Dependent Claim
24 words
The method in accordance with claim 8 wherein said salt of chlorhexidine is selected from the group consisting of the hydrochloride, acetate and gluconate.
Claim 11
Dependent Claim
24 words
The method in accordance with claim 1 wherein said based polymer is selected from the group consisting of polyurethane, polyurethaneurea and siloxane-urethane block copolymer.
Claim 12
Dependent Claim
20 words
The method in accordance with claim 1 wherein said chlorhexidine is about 0.1 to 10% by weight of said polymer.
Claim 13
Dependent Claim
16 words
The method in accordance with claim 1 wherein said melt is formed by twin screw compounding.
Claim 14
Dependent Claim
19 words
The method in accordance with claim 1 further comprising wetting said pellets with a polyol prior to said preparing.
Claim 15
Independent Claim
61 words
A method for preparing a medical article comprising preparing a homogeneous melt of a polymer having a water absorption of at least 0.6% by weight and an anti-infective agent at a temperature range from about 160° C. to about 250° C. and extruding said melt through a die to form a medical article having said agent bulk distributed throughout said polymer.
Claim 16
Independent Claim
61 words
A method for preparing a medical article comprising preparing a homogeneous melt of a polymer having a water absorption of at least 0.6% by weight and an anti-infective agent at a temperature range from about 160° C. to about 250° C. and extruding said melt through a die to form a medical article having said agent bulk distributed throughout said polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-09-18 | 1999-03-20 | 1999-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-09-18 | 2003-03-20 | 2003-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-09-18 | 2007-03-20 | 2007-09-19 | $7700.00 | Window Closed / Lapsed |