US4381380A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thermoplastic polyurethane article treated with iodine for antibacterial use
Assignee: Device Developments Inc
•
Filing: 1980-11-03
•
Granted: 1983-04-26
•
Expires: 2000-11-03
Abstract
Abstract There is provided a polymeric bacteriocidal composition comprising a thermoplastic, partially cross-linked polyurethane having --NH--(C═O)--O-- urethane linkages and/or urea linkages --NH--(C═O)--NH-- and iodine complexed with a sufficient number of these linkages to provide bacteriocidal properties to said composition. The polyurethane has an average molecular weight between 35,000 and 50,000, an ultimate elongation of 200 to 800% and a Shore A scale hardness of 60 to 95. The composition is shaped into a conventional medical appliance form, e.g. a catheter.
Inventors
- 👤 Harry H. Leveen
- 👤 Jeanette L. Rubricius
- 👤 Eric G. LeVeen
- 👤 Robert F. Leveen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 19:04
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/83; A; A01; A01N; A01N25/00; A01N25/34; A01N59/00; A01N59/12; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/26; A61L15/42; A61L15/46; A61L17/00; A61L17/005; A61L29/00; A61L29/04; A61L29/06; A61L29/14; A61L29/16; A61L2300/00; A61L2300/20; A61L2300/202; A61L2300/40; A61L2300/404; Y; Y10; Y10S; Y10S521/00; Y10S521/905
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
120 words
A polymeric bacteriocidal shaped form for medical use comprising a thermoplastic, sparingly cross-linked polyurethane having --NH--(C═O)--O-- urethane linkages and/or urea linkages --NH--(C═O)--NH-- and iodine complexed therewith, said complexed linkages being formed within said polyurethane so that said iodine provides bacteriocidal properties to said polyurethane, said bacteriocidal properties being at least sufficient to inhibit growth of S. Aureus and Proteus Vulgaris type bacteria, said polyurethane having an average molecular weight between 35,000 and 50,000, an ultimate elongation of 200 to 800 percent and a Shore A scale hardness of 60 to 95, said polyurethane being molded into said shaped medical article and thereafter being treated with a solution of iodine to increase the amount of iodine complexed at the linkage sites.
Claim 2
Dependent Claim
120 words
A polymeric bacteriocidal shaped form for medical use comprising a thermoplastic, sparingly cross-linked polyurethane having --NH--(C═O)--O-- urethane linkages and/or urea linkages --NH--(C═O)--NH-- and iodine complexed therewith, said complexed linkages being formed within said polyurethane so that said iodine provides bacteriocidal properties to said polyurethane, said bacteriocidal properties being at least sufficient to inhibit growth of S. Aureus and Proteus Vulgaris type bacteria, said polyurethane having an average molecular weight between 35,000 and 50,000, an ultimate elongation of 200 to 800 percent and a Shore A scale hardness of 60 to 95, said polyurethane being molded into said shaped medical article and thereafter being treated with a solution of iodine to increase the amount of iodine complexed at the linkage sites.
Claim 3
Dependent Claim
19 words
The shaped form of claim 1 wherein the number of complexed linkages is sufficient to render the composition self-sterilizing.
Claim 4
Dependent Claim
16 words
The shaped form of claim 1 wherein the shaped form is a medical or hospital appliance.
Claim 5
Dependent Claim
16 words
The shaped form of claim 1 wherein the shaped form is packaging film or a package.
Claim 6
Dependent Claim
21 words
The appliance of claim 3 in the form of a suture, catheter, tape, tubing, sponge, glove, surgical pad, cover or instrument.
Claim 7
Dependent Claim
35 words
The shaped form of claims 3 or 4 or 5 wherein the shaped form has iodine complexed with the said linkages on or near at least a part of the surface of the shaped form.
Claim 8
Dependent Claim
21 words
The shaped form of claim 1 wherein the complexed iodine is releasably complexed with said linkages and is slowly diffusible therefrom.
Claim 9
Dependent Claim
25 words
The method of producing the shaped form of claim 1, comprising shaping the said polyurethane and contacting the preformed shape with a solution of iodine.
Claim 10
Dependent Claim
14 words
The method of claim 8 wherein the shaped form is extruded, molded or cast.
Claim 11
Dependent Claim
14 words
The method of claim 8 where the solution is a tincture and/or aqueous solution.
Claim 12
Dependent Claim
21 words
The method of claim 8 wherein the concentration of iodine in the solution is at least 1% and up to 15%.
Claim 13
Dependent Claim
28 words
The method of claim 8 wherein the said contacting is at temperatures of from the freezing point of the solution up to the boiling point of the solution.
Claim 14
Dependent Claim
16 words
The method of claim 12 wherein the said temperature is between 20° C. and 60° C.
Claim 15
Dependent Claim
19 words
The method of claim 8 wherein the said contacting is continued for a period of at least 5 minutes.
Claim 16
Dependent Claim
16 words
The method of claim 14 wherein the said period is from 1 hour to 48 hours.
Claim 17
Dependent Claim
14 words
The method of claim 8 wherein after said contacting the shaped form is washed.
Claim 18
Dependent Claim
19 words
The method of claim 16 wherein the washing is with the solvent used to prepare the said iodine solution.
Claim 19
Dependent Claim
12 words
The method of claim 8 wherein the contacting is at elevated pressures.
References Cited (Backward Citations)
GB824215A
Cited
US3235446A
Cited
US3401005A
Cited
US3694413A
Cited
US3598127A
Cited
US3566874A
Cited
US3898326A
Cited
US4017407A
Cited
US3987797A
Cited
US4010259A
Cited
US4054139A
Cited
US4113851A
Cited
US4094967A
Cited
US4239727A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-25 | 1986-10-25 | 1987-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-25 | 1990-10-25 | 1991-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-25 | 1994-10-25 | 1995-04-26 | $7700.00 | Window Closed / Lapsed |