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US5352715A
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Injectable ceramic compositions and methods for their preparation and use
Assignee: Surgical Specialties US Corp
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Filing: 1993-08-02
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Granted: 1994-10-04
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Expires: 2013-08-02
Abstract
Abstract Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 μm to 250 μm. Optionally, the compositions may further comprise collagen, where the relative amounts of collagen and ceramic matrix at least partly determine the physical properties of implants formed by injecting the compositions. The fluid carrier is an aqueous buffered medium, typically including an organic polymer base material when there is no collagen present in the composition. The compositions are particularly suitable for repair and augmentation of soft and hard tissues by injection.
Inventors
- 👤 Donald G. Wallace
- 👤 Hugh McMullin
- 👤 George Chu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:48
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/02; A61L27/10; A61L27/12; A61L27/40; A61L27/44; A61L27/46; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
39 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 2
Dependent Claim
39 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 3
Dependent Claim
18 words
An injectable implant composition as in claim 1, wherein the ceramic particles are composed of calcium phosphate mineral.
Claim 4
Dependent Claim
25 words
An injectable implant composition as in claim 2, wherein the calcium phosphate mineral is selected from the group consisting of sintered hydroxyapatite and tricalcium phosphate.
Claim 5
Independent Claim
43 words
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 6
Independent Claim
43 words
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 7
Dependent Claim
17 words
A method as in claim 4, wherein the ceramic particles are composed of calcium phosphate mineral particles.
Claim 8
Dependent Claim
28 words
A method as in claim 4, wherein the calcium phosphate mineral particles are composed of a material selected from the group consisting of sintered hydroxyapatite and tricalcium phosphate.
Claim 9
Dependent Claim
27 words
A method as in claim 4, wherein the fluid carrier comprises a biocompatible organic polymer which will dissipate from a tissue injection site, leaving the mineral particles.
Claim 10
Dependent Claim
14 words
A method as in claim 7, wherein the organic polymer is a polyethylene glycol.
Claim 11
Dependent Claim
39 words
A kit comprising: a syringe loaded with a volume of collagen and biocompatible ceramic particles which have been size selected to have a size distribution in the range from 50 μm to 250 μm present in a fluid carrier.
Claim 12
Dependent Claim
39 words
A kit comprising: a syringe loaded with a volume of collagen and biocompatible ceramic particles which have been size selected to have a size distribution in the range from 50 μm to 250 μm present in a fluid carrier.
Claim 13
Independent Claim
53 words
A method for preparing injectable implant compositions, said method comprising: providing a ceramic material in the form of a fine powder; screening the fine powder to remove ceramic particles sized above 250 μm and below 50 μm; and combining the fine powder remaining after screening with collagen and a pharmaceutically acceptable fluid carrier.
Claim 14
Independent Claim
53 words
A method for preparing injectable implant compositions, said method comprising: providing a ceramic material in the form of a fine powder; screening the fine powder to remove ceramic particles sized above 250 μm and below 50 μm; and combining the fine powder remaining after screening with collagen and a pharmaceutically acceptable fluid carrier.
Claim 15
Dependent Claim
23 words
A method as in claim 10, wherein the ceramic powder is treated to enhance surface porosity prior to combination with the fluid carrier.
Claim 16
Dependent Claim
17 words
A method as in claim 10, wherein the ceramic powder is composed of calcium phosphate mineral particles.
Claim 17
Dependent Claim
28 words
A method as in claim 12, wherein the calcium phosphate mineral particles are composed of a material selected from the group consisting of sintered hydroxyapatite and tricalcium phosphate.
Claim 18
Dependent Claim
25 words
A method as in claim 10, wherein the ceramic powder is combined in the fluid carrier at a concentration from 0.75 gm/ml to 0.05 gm/ml.
Claim 19
Dependent Claim
27 words
A method as in claim 10, wherein the fluid carrier comprises a biocompatible organic polymer which will dissipate from a tissue injection site, leaving the mineral particles.
Claim 20
Dependent Claim
14 words
A method as in claim 15, wherein the organic polymer is a polyethylene glycol.
Claim 21
Dependent Claim
29 words
A method as in claim 10, wherein the ceramic powder and the collagen are combined at a weight ratio in the range from 1:19 to 1:1 ceramic powder: collagen.
Claim 22
Dependent Claim
19 words
A method as in claim 10, further comprising combining the pharmaceutically acceptable fluid carrier with a biocompatible fluid lubricant.
Claim 23
Dependent Claim
16 words
A method as in claim 18, wherein the biocompatible fluid lubricant is glycerol of succinylated collagen.
Claim 24
Dependent Claim
15 words
A method as in claim 10, further comprising combining at least one biologically active substance.
Claim 25
Dependent Claim
24 words
A method as in claim 20, wherein the substance is selected from the group consisting of tissue growth factors, osteogenic factors, and bone marrow.
Claim 26
Dependent Claim
48 words
An injectable implant composition comprising collagen and ceramic particles composed of calcium phosphate mineral and having enhanced surface porosity present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 27
Dependent Claim
48 words
An injectable implant composition comprising collagen and ceramic particles composed of calcium phosphate mineral and having enhanced surface porosity present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 28
Dependent Claim
48 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier at a concentration from 0.75 gm/ml to 0.05 gm/ml, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 29
Dependent Claim
48 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier at a concentration from 0.75 gm/ml to 0.05 gm/ml, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 30
Dependent Claim
52 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a biocompatible organic polymer which will dissipate from a tissue injection site leaving the ceramic particles and collagen, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 31
Dependent Claim
52 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a biocompatible organic polymer which will dissipate from a tissue injection site leaving the ceramic particles and collagen, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 32
Dependent Claim
15 words
An injectable implant composition a in claim 24, wherein the organic polymer is polyethylene glycol.
Claim 33
Dependent Claim
53 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier at a weight ratio in the range from 1:19 to 1:1 ceramic particles: collagen, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 34
Dependent Claim
53 words
An injectable implant composition comprising collagen and biocompatible ceramic particles present in a pharmaceutically acceptable fluid carrier at a weight ratio in the range from 1:19 to 1:1 ceramic particles: collagen, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 35
Dependent Claim
43 words
An injectable implant composition comprising collagen, biocompatible ceramic particles, and a biocompatible fluid lubricant, present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 36
Dependent Claim
43 words
An injectable implant composition comprising collagen, biocompatible ceramic particles, and a biocompatible fluid lubricant, present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 37
Dependent Claim
17 words
An injectable implant composition as in claim 27, wherein the biocompatible lubricant is glycerol or succinylated collagen.
Claim 38
Dependent Claim
45 words
An injectable implant composition comprising collagen, biocompatible ceramic particles, and at least one biologically active substance present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 39
Dependent Claim
45 words
An injectable implant composition comprising collagen, biocompatible ceramic particles, and at least one biologically active substance present in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size distribution in the range from 50 μm to 250 μm.
Claim 40
Dependent Claim
24 words
An injectable implant composition as in claim 29 wherein the biologically active substance is a tissue growth factor, an osteogenic factor, or bone marrow.
Claim 41
Independent Claim
50 words
An method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier wherein the ceramic particles have been treated to enhance surface porosity prior to combining and have been size selected to have a size from 50 μm to 250 μm.
Claim 42
Independent Claim
50 words
An method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier wherein the ceramic particles have been treated to enhance surface porosity prior to combining and have been size selected to have a size from 50 μm to 250 μm.
Claim 43
Independent Claim
48 words
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier at a concentration from 0.75 gm/ml to 0.05 gm/ml, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 44
Independent Claim
48 words
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier at a concentration from 0.75 gm/ml to 0.05 gm/ml, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 45
Independent Claim
53 words
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier at a weight ratio in the range from 1:19 to 1:1 ceramic particles: collagen, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 46
Independent Claim
53 words
A method for preparing injectable implant compositions, said method comprising combining ceramic particles and collagen in a pharmaceutically acceptable fluid carrier at a weight ratio in the range from 1:19 to 1:1 ceramic particles: collagen, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 47
Independent Claim
42 words
A method for preparing injectable implant-compositions, said method comprising combining ceramic particles, collagen, and a biocompatible fluid lubricant in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 48
Independent Claim
42 words
A method for preparing injectable implant-compositions, said method comprising combining ceramic particles, collagen, and a biocompatible fluid lubricant in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 49
Dependent Claim
16 words
A method as in claim 34, wherein the biocompatible fluid lubricant is glycerol or succinylated collagen.
Claim 50
Independent Claim
43 words
A method for preparing injectable implant compositions comprising combining ceramic particles, collagen, and at least one biologically active substance, in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 51
Independent Claim
43 words
A method for preparing injectable implant compositions comprising combining ceramic particles, collagen, and at least one biologically active substance, in a pharmaceutically acceptable fluid carrier, wherein the ceramic particles have been size selected to have a size from 50 μm to 250 μm.
Claim 52
Dependent Claim
26 words
A method as in claim 36, wherein the biologically active substance is selected from the group consisting of tissue growth factors, osteogenic factors, and bone marrow.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-10-03 | 1998-04-04 | 1998-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-03 | 2002-04-04 | 2002-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-03 | 2006-04-04 | 2006-10-04 | $7700.00 | Window Closed / Lapsed |