Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen

Claim 1

A composition comprising an aqueous suspension of atelocollagen adjusted for physiological conditions by a buffer to a concentration of 55 to 75 mg/ml of said atelocollagen, wherein said atelocollagen is cross-linked with a polyepoxy compound in an amount of 20 to 100% by weight and not less than 10% of amino side chain groups of atelocollagen contained in said cross-linked atelocollagen are cross-linked with said polyepoxy compound, said polyepoxy compound is a member selected from the group consisting of glycerol diglycidyl ether, glycerol triglycidyl ether, diglycerol tetraglycidyl ether, triglycerol pentaglycidy ether, poly (methylene glycol) diglycidyl ether (1-10 polymerization degree), poly (ethylene glycol) diglycidyl ether (1-10 polymerization degree), poly (trimethylene glycol) diglycidyl ether (1-8 polymerization degree) and poly (propylene glycol) diglycidyl ether (1-8 polymerization degree), said cross-linked atelocollagen has a transition point of not less than 40° C. as measured by a differential scanning calorimeter, and said composition has a viscosity sufficient for injection through a needle.