US4242291A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Collagen reconstitution
Assignee: Battelle Memorial Institute Inc
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Filing: 1979-05-09
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Granted: 1980-12-30
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Expires: 1999-05-09
Abstract
Abstract The effect of earth gravity on the self assembly of tropocollagen molecules into collagen fibrils and on the aggregation of fibrils into collagen gels has been found to be surprisingly detrimental to the preparation of desirable biomaterials. Chemically and physically uniform biomaterials for use in repair or replacement of damaged or diseased human tissue and organs are prepared by otherwise conventional reconstitution of soluble tropocollagen carried out, however, under less than one gravity, preferably under zero gravity. Surprisingly better properties of the collagen aggregate suggest that improved biomaterials may be prepared from the uniform gels.
Inventors
- 👤 Kenneth E. Hughes
- 👤 Dale P. DeVore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:24
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
43 words
A method for production of a homogeneous gel matrix of unique collagen fibrils by the old method of precipitation from a solution comprising solubilized collagen molecules wherein the improvement comprises carrying out the old method under gravitational force of less than one gravity.
Claim 2
Independent Claim
43 words
A method for production of a homogeneous gel matrix of unique collagen fibrils by the old method of precipitation from a solution comprising solubilized collagen molecules wherein the improvement comprises carrying out the old method under gravitational force of less than one gravity.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein the solution additionally comprises property altering materials selected from carbohydrates and proteins.
Claim 4
Dependent Claim
13 words
The method of claim 2, wherein the property altering material is a mucopolysaccharide.
Claim 5
Dependent Claim
17 words
The method of claim 1 or 2, wherein the method is carried out under about zero gravity.
Claim 6
Dependent Claim
34 words
The method of claim 1, wherein the solution is acidic and the soluble collagen molecules are fibrilized and precipitated by raising the pH above about 7 at a temperature of above about 4° C.
Claim 7
Independent Claim
44 words
The method for production of an individual eye lens blank comprising (a) providing a solution comprising solubilized tropocollagen molecules in an eye lens mold, and (b) precipitating a homogeneous, self-supporting collagen gel matrix from the solution under gravitational force of less than one gravity.
Claim 8
Independent Claim
44 words
The method for production of an individual eye lens blank comprising (a) providing a solution comprising solubilized tropocollagen molecules in an eye lens mold, and (b) precipitating a homogeneous, self-supporting collagen gel matrix from the solution under gravitational force of less than one gravity.
Claim 9
Independent Claim
71 words
The method for production of an eye lens prosthesis by the method of shaping a lens blank to the desired contour wherein the improvement comprises forming the lens blank by (a) providing a thin film of a solution comprising solubilized tropocollagen molecules, (b) precipitating a homogeneous, self-supporting gel sheet from the solution under gravitational force of less than one gravity, and (c) cutting the eye lens blank from the gel sheet.
Claim 10
Independent Claim
71 words
The method for production of an eye lens prosthesis by the method of shaping a lens blank to the desired contour wherein the improvement comprises forming the lens blank by (a) providing a thin film of a solution comprising solubilized tropocollagen molecules, (b) precipitating a homogeneous, self-supporting gel sheet from the solution under gravitational force of less than one gravity, and (c) cutting the eye lens blank from the gel sheet.
References Cited (Backward Citations)
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JPS4939174A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-30 | 1984-06-30 | 1984-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-30 | 1988-06-30 | 1988-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-30 | 1992-06-30 | 1992-12-30 | $7700.00 | Window Closed / Lapsed |