Patent GB486237A successfully refreshed from Google Patents.
EP0411124A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Medical material permitting cells to enter thereinto and artificial skin
Assignee: Terumo Corp
•
Filing: 1989-03-09
•
Granted: —
•
Expires: 2009-03-09
Abstract
Abstract A medical material permitting cells to enter thereinto which comprises a modified collagen prepared by heat-treating collagen having a crosslinked structure in the presence of water is disclosed. An artificial skin using this medical material as a wound-contacting layer is also disclosed.
Inventors
- 👤 Katsutoshi Yoshisato
- 👤 Jun Terumo Kabushiki Kaisha Konishi
- 👤 Mikio Terumo Kabushiki Kaisha Koide
- 👤 Kaoru Terumo Kabushiki Kaisha Oyamada
- 👤 Kenichi Terumo Kabushiki Kaisha Ohsaki
- 👤 Takeo Terumo Kabushiki Kaisha Katakura
- 👤 Yuichi Mori
- 👤 Ken Terumo Kabushiki Kaisha 2656-1 Tatebe
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 08:17
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/60; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
23 words
Cell-penetrable medical material characterized in being made of denatured collagen prepared by heating, in the presence of water, the collagen having cross-linking structure.
Claim 2
Dependent Claim
23 words
Cell-penetrable medical material characterized in being made of denatured collagen prepared by heating, in the presence of water, the collagen having cross-linking structure.
Claim 3
Dependent Claim
24 words
Medical material according to claim 1, in which said denatured collagen is lack of the moiety having antigenicity at the terminal of collagen molecule.
Claim 4
Dependent Claim
17 words
Medical material according to claim 1, in which said denatured collagen contains 0 to 80% of helix.
Claim 5
Dependent Claim
24 words
Cell-penetrable medical material characterized in being made from denatured collagen prepared by heating, in the presence of water, the fibrous collagen having cross-linking structure.
Claim 6
Dependent Claim
24 words
Cell-penetrable medical material characterized in being made from denatured collagen prepared by heating, in the presence of water, the fibrous collagen having cross-linking structure.
Claim 7
Dependent Claim
24 words
Medical material according to claim 4, in which said denatured collagen is lack of the moiety having antigenicity at the terminal of collagen molecule.
Claim 8
Dependent Claim
17 words
Medical material according to claim 4, in which said denatured collagen contains 0 to 80% of helix.
Claim 9
Dependent Claim
17 words
Medical material according to claim 4, in which it is in the form of film or sponge.
Claim 10
Dependent Claim
44 words
Process for preparing cell-penetrable medical material comprising: a) a step of subjecting collagen to cross-linking treatment to give the collagen having cross-linking structure, and b) a step of heating, in the presence of water, the collagen having cross-linking structure at 50 to 120° C.
Claim 11
Dependent Claim
44 words
Process for preparing cell-penetrable medical material comprising: a) a step of subjecting collagen to cross-linking treatment to give the collagen having cross-linking structure, and b) a step of heating, in the presence of water, the collagen having cross-linking structure at 50 to 120° C.
Claim 12
Dependent Claim
23 words
Process according to claim 8, in which fibrous collagen is used as the collagen to be subjected to cross-linking treatment in Step a).
Claim 13
Dependent Claim
32 words
Process according to claim 8, in which the collagen lack of the moiety having antigenicity at the terminal of collagen molecule is used as the collagen to be cross-linked in Step a).
Claim 14
Dependent Claim
18 words
Process according to claim 8, in which the cross-linking treatment in Step a) is dehydrating procedure under heating.
Claim 15
Dependent Claim
19 words
Process according to claim 8, in which the cross-linking treatment in Step a) is treatment with a cross-linking agent.
Claim 16
Dependent Claim
17 words
Process according to claim 12, in which concentration of said cross-linking agent is 0.01 to 5% (w/v).
Claim 17
Dependent Claim
60 words
Artificial skin comprising: a supporting layer made from fibroin; a wound-contacting layer laminated on one side of said supporting layer and a water permeation-controlling layer laminated on the other side of said supporting layer for controlling water permeation said wound-contacting layer being made of the denatured collagen prepared by heating, in the presence of water, the collagen having cross-linking structure.
Claim 18
Dependent Claim
60 words
Artificial skin comprising: a supporting layer made from fibroin; a wound-contacting layer laminated on one side of said supporting layer and a water permeation-controlling layer laminated on the other side of said supporting layer for controlling water permeation said wound-contacting layer being made of the denatured collagen prepared by heating, in the presence of water, the collagen having cross-linking structure.
Claim 19
Dependent Claim
24 words
Artificial skin according to claim 14, in which said denatured collagen is lack of the moiety having antigenicity at the terminal of collagen molecule.
Claim 20
Dependent Claim
25 words
Artificial skin according to claim 14, in which said denatured collagen is prepared by heating, in the presence of water, fibrous collagen having cross-linking structure.
Claim 21
Dependent Claim
14 words
Artificial skin according to claim 14, in which said wound-contacting layer takes sponge form.
Claim 22
Dependent Claim
17 words
Artificial skin according to claim 14, in which said denatured collagen contains 0 to 80% of helix.
Claim 23
Dependent Claim
18 words
Artificial skin according to claim 14, in which fibroin of said supporting layer takes water-insoluble unwoven porous form.
Claim 24
Dependent Claim
31 words
Artificial skin according to claim 14, in which said water permeation-controlling layer is made of non-toxic materials selected from the group consisting of silicone resin, polyacrylate ester, polymethacrylate ester and polyurethane.
Claim 25
Dependent Claim
21 words
Artificial skin according to claim 14, in which said water permeation-controlling layer has water flux of about 0.1 to 1 mg/cm2/hour.
Claim 26
Dependent Claim
25 words
Artificial skin according to claim 14, in which at least one of said wound-contacting layer, supporting layer and water permeation controlling layer contains antibacterial agent.
Claim 27
Dependent Claim
24 words
Artificial skin according to claim 14, in which said antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamycin and silver nitrate.
Claim 28
Dependent Claim
44 words
Artificial skin comprising: a wound-contacting layer; and a water permeation-controlling layer laminated on one side of said wound-contacting layer for controlling water permeation, said wound-contacting layer being made of denatured collagen obtained by heating, in the presence of water, the collagen having cross-linking structure.
Claim 29
Dependent Claim
44 words
Artificial skin comprising: a wound-contacting layer; and a water permeation-controlling layer laminated on one side of said wound-contacting layer for controlling water permeation, said wound-contacting layer being made of denatured collagen obtained by heating, in the presence of water, the collagen having cross-linking structure.
Claim 30
Dependent Claim
24 words
Artificial skin according to claim 24, in which said denatured collagen is lack of the moiety having antigenicity at the terminal of collagen molecule.
Claim 31
Dependent Claim
26 words
Artificial skin according to claim 24, in which said denatured collagen is prepared by heating, in the presence of water, the fibrous collagen having cross-linking structure.
Claim 32
Dependent Claim
14 words
Artificial skin according to claim 24, in which said wound-contacting layer takes sponge form.
Claim 33
Dependent Claim
17 words
Artificial skin according to claim 24, in which said denatured collagen contains 0 to 80% of helix.
Claim 34
Dependent Claim
31 words
Artificial skin according to claim 24, in which said water permeation-controlling layer is made of non-toxic material selected from the group consisting of silicone resin, polyacrylate ester, polymethacrylate ester and polyurethane.
Claim 35
Dependent Claim
23 words
Artificial skin according to claim 24, in which said water permeation-controlling layer has water flux of about 0.1 to 1 mg/cm 2 /hour.
Claim 36
Dependent Claim
23 words
Artificial skin according to claim 24, in which at least one of wound-contacting layer, supporting layer and water permeation-controlling layer contains antibacterial agent.
Claim 37
Dependent Claim
24 words
Artificial skin according to claim 31, in which said antibacterial agent is selected from the group consisting of silver sulfadiazine, gentamycin and silver nitrate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.