US5246457A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Xenogeneic collagen/mineral preparations in bone repair
Assignee: Allergan Inc
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Filing: 1990-12-17
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Granted: 1993-09-21
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Expires: 2010-12-17
Abstract
Abstract A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
Inventors
- 👤 Karl A. Piez
- 👤 Bruce B. Pharriss
- 👤 George H. Chu
- 👤 Thomas L. Smestad
- 👤 Diana Hendricks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:37
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2835; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
90 words
A conductive bone-repair composition which contains a mixture consisting essentially of about 94% calcium phosphate particulate mineral component, said mineral component being a mixture of about 60% hydroxyapatite and about 40% tricalcium phosphate, in admixture with about 6% of atelopeptide reconstituted fibrillar collagen, said composition prepared by a process comprising mixing a dispersion of said collagen at a concentration of about 25 mg/ml with said mineral component in dry particulate form to obtain a composition, followed by molding and lyophilizing the composition in the mold to obtain a dried composition.
Claim 2
Dependent Claim
90 words
A conductive bone-repair composition which contains a mixture consisting essentially of about 94% calcium phosphate particulate mineral component, said mineral component being a mixture of about 60% hydroxyapatite and about 40% tricalcium phosphate, in admixture with about 6% of atelopeptide reconstituted fibrillar collagen, said composition prepared by a process comprising mixing a dispersion of said collagen at a concentration of about 25 mg/ml with said mineral component in dry particulate form to obtain a composition, followed by molding and lyophilizing the composition in the mold to obtain a dried composition.
Claim 3
Dependent Claim
39 words
The product of claim 1 which is prepared by said process further including the step of heat curing the dried composition under aseptic conditions to obtain a cured product of rupture strength of greater than 0.15 Newtons/cm 2 .
Claim 4
Dependent Claim
46 words
The product of claim 2 which is prepared by said process further including rehumidifying the dried composition to obtain a rehumidified composition and irradiating the rehumidified composition with gamma irradiation to obtain a sterilized product with a rupture strength of greater than 0.15 Newtons/cm 2 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-20 | 1997-03-22 | 1997-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-20 | 2001-03-22 | 2001-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-20 | 2005-03-22 | 2005-09-21 | $7700.00 | Window Closed / Lapsed |