US3892648A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electrochemical deposition of bone
Assignee: United States Department of the Navy
•
Filing: 1974-04-16
•
Granted: 1975-07-01
•
Expires: 1994-04-16
Abstract
Abstract A method of improving orthopedic implant materials by the simultaneous electrodeposition of bone and collagen onto a prosthesis is provided. Collagen fibrils are dispensed in a gelatin medium and the gelled collagen is dissolved in a waterglycerine solution. Finely divided bone particles are then added to this solution and, by applying a voltage to a pair of electrodes immersed in the solution, adherent bone and collagen coatings of preferably 1-5 mils thickness are formed on the cathodic electrode.
Inventors
- 👤 David C Phillips
- 👤 Bevil J Shaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:01
CPC Classifications
C; C25; C25D; C25D13/00; A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61F2310/00; A61F2310/00389; A61F2310/00958; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
52 words
A METHOD OF FORMING A PROTHESIS FOR BONE REPAIR OR REPLACEMENT COMPRISING: ELECTRODEPOSITING FINELY DIVIDED POWDERED BONE PARTICLES FROM AQUEOUS GLYCERIN AND COLLAGEN DISPERSIONS ONTO A METALLIC SUBSTRATE TO FORM THE PROSTHESIS AS A COATING ON THE SUBSTRATE, AND REMOVING THE METALLIC SUBSTRATE BY DISSOLUTION DURING AND AFTER FORMATION OF THE PROSTHESIS.
Claim 2
Independent Claim
52 words
A METHOD OF FORMING A PROTHESIS FOR BONE REPAIR OR REPLACEMENT COMPRISING: ELECTRODEPOSITING FINELY DIVIDED POWDERED BONE PARTICLES FROM AQUEOUS GLYCERIN AND COLLAGEN DISPERSIONS ONTO A METALLIC SUBSTRATE TO FORM THE PROSTHESIS AS A COATING ON THE SUBSTRATE, AND REMOVING THE METALLIC SUBSTRATE BY DISSOLUTION DURING AND AFTER FORMATION OF THE PROSTHESIS.
Claim 3
Dependent Claim
35 words
The method of claim 1 wherein said aqueous glycerin and collagen dispersions comprise translucent, viscosity-time stable, thixotropic pseudoplastic gels having a pH in the range of from 2.5 to 4 for suspending said bone particles.
Claim 4
Independent Claim
136 words
A method of producing an orthopedic implant for enhancing bone repair rates in bone bridge and other bone repair operations comprising: dispensing collagen fibrils in a gelatin medium formed from the class of hydrophilic materials which includes methanol, glycerin, formamide, dimethylsulfoxide, ethanol solutions of up to substantially 40% alcohol/60% water by weight, isopropanol solution of up to substantially 40%/60% water by weight; dissolving the medium in a water-glycerin solution of 50% water and 50% glycerin by weight; adding finely divided bone particles to the solution; immersing a pair of electrodes one of which is a metallic substrate for a bone prosthesis in the solution; applying a voltage to said electrodes wherein the metallic substrate is the cathode; and forming coatings of bone and collagen on said substrate to a thickness of from 1 to 5 mils.
Claim 5
Independent Claim
136 words
A method of producing an orthopedic implant for enhancing bone repair rates in bone bridge and other bone repair operations comprising: dispensing collagen fibrils in a gelatin medium formed from the class of hydrophilic materials which includes methanol, glycerin, formamide, dimethylsulfoxide, ethanol solutions of up to substantially 40% alcohol/60% water by weight, isopropanol solution of up to substantially 40%/60% water by weight; dissolving the medium in a water-glycerin solution of 50% water and 50% glycerin by weight; adding finely divided bone particles to the solution; immersing a pair of electrodes one of which is a metallic substrate for a bone prosthesis in the solution; applying a voltage to said electrodes wherein the metallic substrate is the cathode; and forming coatings of bone and collagen on said substrate to a thickness of from 1 to 5 mils.
Claim 6
Dependent Claim
24 words
The method of claim 3 wherein said bone particles are dispersed in a gel matrix, said matrix suspending said particles uniformly throughout said medium.
Claim 7
Independent Claim
42 words
The method of calim 4 wherein said medium comprises a microcrystalline collagen in the form of a water insoluble partial acid salt of edible bovine collagen, said gel produced from said medium containing particles substantially less than one micron in any dimension.
Claim 8
Independent Claim
42 words
The method of calim 4 wherein said medium comprises a microcrystalline collagen in the form of a water insoluble partial acid salt of edible bovine collagen, said gel produced from said medium containing particles substantially less than one micron in any dimension.
Claim 9
Dependent Claim
33 words
The method of claim 5 wherein said collagen is a polypeptide collagen having a high molecular weight which is attained by sub-micron micrycrystalline containing highly polar groups such as NH, NH2, and OH.
Claim 10
Dependent Claim
46 words
The method of claim 6 wherein said gel is prepared by attriting collagen fibers in said medium for a period of from 15-30 minutes in a blender; said fibers allowed to soak for 5 minutes in said medium and thereafter attrited to maintain a controllable vortex.
Claim 11
Dependent Claim
56 words
The method of claim 7 wherein the resultant gel is filtered through a sintered glass filter to remove the larger undispersed fibrils and particle aggregates; a selected amount of powdered bone added to said gel, said gel further agitated so as to obtain a suspension of finely divided bone in the gel matrix of microcrystalline collagen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-30 | 1978-12-30 | 1979-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-30 | 1982-12-30 | 1983-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-30 | 1986-12-30 | 1987-07-01 | $7700.00 | Window Closed / Lapsed |