US5035715A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gamma irradiation of collagen/mineral mixtures
Assignee: Allergan Inc
•
Filing: 1989-05-24
•
Granted: 1991-07-30
•
Expires: 2009-05-24
Abstract
Abstract A biocompatible collagen/mineral composition which comprises a mixture of 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight, exclusive of water, is disclosed. The composition has a sterility assurance factor of at least as low as 10 -6 and either a compressive modulus of at least 10 N/cm -2 or a tensile strength of about 3-12 N/cm -2 .
Inventors
- 👤 Thomas L. Smestad
- 👤 Daniel Prowse
- 👤 George H. Chu
- 👤 Diana M. Hendricks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:57
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/081; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61L2103/00; A61L2103/05; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
68 words
A biocompatible collagen/mineral composition which comprises a mixture containing 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture, which composition has a sterility assurance factor of at least as low as 10 -6 and an additional characteristic selected from the group consisting of a compressive modulus of at least 10 N/cm 2 and a tensile strength of about 3-12 N/cm 2 .
Claim 2
Dependent Claim
68 words
A biocompatible collagen/mineral composition which comprises a mixture containing 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture, which composition has a sterility assurance factor of at least as low as 10 -6 and an additional characteristic selected from the group consisting of a compressive modulus of at least 10 N/cm 2 and a tensile strength of about 3-12 N/cm 2 .
Claim 3
Dependent Claim
13 words
The composition of claim 1 which has a moisture content of 0.5-15 wt%.
Claim 4
Dependent Claim
22 words
The composition of claim 1 which has a collagen content of about 10-13%, and a calcium phosphate mineral content of about 82-90%.
Claim 5
Dependent Claim
22 words
The composition of claim 1 which has a collagen content of about 6-12%, and a calcium phosphate mineral content of about 78-89%.
Claim 6
Dependent Claim
10 words
The composition of claim 1 which further comprises an antibiotic.
Claim 7
Dependent Claim
69 words
A biocompatible collagen/mineral composition which comprises a mixture containing 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture, which composition has a sterility assurance factor of at least as low as 10 -6 and an additional characteristic selected from the gruop consisting of a compressible modulus in the range of 25-45 N/cm 2 and a tensile strength of about 3-12 N/cm 2 .
Claim 8
Dependent Claim
69 words
A biocompatible collagen/mineral composition which comprises a mixture containing 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture, which composition has a sterility assurance factor of at least as low as 10 -6 and an additional characteristic selected from the gruop consisting of a compressible modulus in the range of 25-45 N/cm 2 and a tensile strength of about 3-12 N/cm 2 .
References Cited (Backward Citations)
US3443261A
Cited
US3767437A
Cited
US3949073A
Cited
US4140537A
Cited
US4291013A
Cited
US4516276A
Cited
EP0030583A1
Cited
JPS5841A
Cited
US4424208A
Cited
US4582640A
Cited
US4623553A
Cited
US4789663A
Cited
US4553974A
Cited
US4642117A
Cited
US4795467A
Cited
EP0246638A2
Cited
US4865602A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-29 | 1995-01-28 | 1995-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-29 | 1999-01-28 | 1999-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-29 | 2003-01-28 | 2003-07-30 | $7700.00 | Window Closed / Lapsed |