Patent US4830023A successfully refreshed from Google Patents.
Patent US4832686A successfully refreshed from Google Patents.
US4832686A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for administering interleukin-2
Assignee: Individual
•
Filing: 1986-06-24
•
Granted: 1989-05-23
•
Expires: 2006-06-24
Abstract
Abstract A biocompatible, biodegradable, bioerodible composite polymer matrix comprising interleukin-2 in an appropriate polymer. The polymer may be a polymer or copolymer of lactic acid, lactide, glycolide, glutamic acid, or it may be collagen or albumin. The material contains from 10 2 to 10 8 U IL-2/g of polymer. Also disclosed is a method for making the composite polyer matrix and a method for implanting the material. A soft, malleable controlled-release composite material may be used for intracranial or other implantation and may be shaped or molded to fit the site from which malignant tissue has been removed, opposing the residual tumor, complementing hemostasis, compatible with anatomical structure, and functioning as an implantable immunotherapeutic adjuvant.
Inventors
- 👤 Mark E. Anderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
45 words
A method for administering interleukin-2, comprising the step of intracranially implanting into an area from which a neoplasm has been removed a controlled-release polymer matrix, comprising a biocompatible, bioerodible, hemostatic polylactic acid polymer material and interleukin-2 which material is malleable at the time of implantation.
Claim 2
Independent Claim
45 words
A method for administering interleukin-2, comprising the step of intracranially implanting into an area from which a neoplasm has been removed a controlled-release polymer matrix, comprising a biocompatible, bioerodible, hemostatic polylactic acid polymer material and interleukin-2 which material is malleable at the time of implantation.
Claim 3
Dependent Claim
10 words
The method of claim 1, wherein said neoplasm is glioblastoma.
Claim 4
Dependent Claim
33 words
The method of claim 1, further comprising the step of shaping said polymer material to fit the site from which said neoplasm was removed, thereby restoring the brain to its normal anatomical configuration.
Claim 5
Dependent Claim
14 words
The method of claim 1, wherein said polymer matrix further comprises a chemotherapeutic agent.
Claim 6
Dependent Claim
12 words
The method of claim 4, wherein said chemotherapeutic agent is a nitrosourea.
Claim 7
Dependent Claim
13 words
The method of claim 5, wherein said chemotherapeutic agent is BCNU or methyl-CCNU.
Claim 8
Dependent Claim
16 words
The method of claim 1, wherein said polymer matrix is in the form of a paste.
References Cited (Backward Citations)
US3887699A
Cited
US4419340A
Cited
US4060089A
Cited
US4186448A
Cited
US4300565A
Cited
US4265233A
Cited
US4411027A
Cited
US4512038A
Cited
US4338926A
Cited
US4298998A
Cited
US4428082A
Cited
US4404280A
Cited
US4402445A
Cited
US4513746A
Cited
US4506681A
Cited
US4536387A
Cited
US4474181A
Cited
US4553542A
Cited
US4526938A
Cited
GB2121053A
Cited
US4490289A
Cited
US4440789A
Cited
US4439420A
Cited
US4443430A
Cited
US4534349A
Cited
US4518611A
Cited
US4518584A
Cited
EP0139286A2
Cited
EP0140255A2
Cited
EP0145240A2
Cited
US4568559A
Cited
US4563489A
Cited
EP0154316A2
Cited
EP0158487A2
Cited
US4619913A
Cited
DE3536902A1
Cited
US4568536A
Cited
US4650665A
Cited
EP0251631A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |