US4419340A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release of anticancer agents from biodegradable polymers
Assignee: University of Delaware
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Filing: 1980-11-20
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Granted: 1983-12-06
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Expires: 2000-11-20
Abstract
Abstract Polymeric articles for controllably dispensing anticancer agents are disclosed which are formed from biodegradable polymeric materials containing the agents.
Inventors
- 👤 Seymour Yolles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:18
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/0034; A61K9/0039; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/70; A61K9/7007; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
89 words
An implant drug dispensing device article for prolonged administration upon implantation of an anticancer agent which comprises, a solid shaped article formed from a combination of (a) a biodegradable polymer selected from poly(lactic acid) or polyglycolic acid, and, substantially uniformly and intimately dispersed throughout portions of the article, (b) cis-dichlorodiammine-platinum (II), and (c) doxorubicin or cyclophosphamide each being present in administrable doseage being much larger than those normally toxic, to lower than are normally infused by injection, and having an average particle size of from 150 to 425 microns.
Claim 2
Dependent Claim
89 words
An implant drug dispensing device article for prolonged administration upon implantation of an anticancer agent which comprises, a solid shaped article formed from a combination of (a) a biodegradable polymer selected from poly(lactic acid) or polyglycolic acid, and, substantially uniformly and intimately dispersed throughout portions of the article, (b) cis-dichlorodiammine-platinum (II), and (c) doxorubicin or cyclophosphamide each being present in administrable doseage being much larger than those normally toxic, to lower than are normally infused by injection, and having an average particle size of from 150 to 425 microns.
Claim 3
Dependent Claim
12 words
The article of claim 1 wherein the biodegradable polymer is poly(lactic acid).
Claim 4
Dependent Claim
28 words
A method of treating cancer in a mammal susceptible to treatment with cis-dichlorodiammine-platinum (II) comprising implanting an article according to claim 1 into the body of said mammal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-05 | 1987-06-06 | 1987-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-05 | 1991-06-06 | 1991-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-05 | 1995-06-06 | 1995-12-06 | $7700.00 | Window Closed / Lapsed |