EP0145240A2
Expired / Lapsed
EP
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Method for producing Microcapsule
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1984-11-02
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Granted: —
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Expires: 2004-11-02
Abstract
Abstract A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oit layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of said water-soluble drug.
Inventors
- 👤 Hiroaki Okada
- 👤 Yasuaki Ogawa
- 👤 Takatsuka Yashiki
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 04:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031; A61K38/00; A61K38/04; A61K38/05; A61K38/08; A61K38/09; A61K38/16; A61K38/17; A61K38/33; A61K38/36; A61K38/37; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1682; A61K9/1694; A61K9/5089; B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/12; B01J13/125; Y; Y10; Y10S; Y10S424/00; Y10S424/15; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2989
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
64 words
A prolonged release microcapsule, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing a water-soluble drug and a drug retaining substance therefor and an oil layer containing a high polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centipoises and finally subjecting the resulting emulsion to in water drying.
Claim 2
Dependent Claim
64 words
A prolonged release microcapsule, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing a water-soluble drug and a drug retaining substance therefor and an oil layer containing a high polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centipoises and finally subjecting the resulting emulsion to in water drying.
Claim 3
Dependent Claim
16 words
A microcapsule as claimed in claim 1, wherein the water-soluble drug is a biologically active polypeptide.
Claim 4
Dependent Claim
20 words
A microcapsule as claimed in Claim, 2, wherein the biologically active polypeptide is (Pyr)Glu-His-Trp-Ser- T yr-D-Leu-Leu-Arg-Pro-NH-C 2 H 5 .
Claim 5
Dependent Claim
19 words
A microcapsule as claimed in Claim 1, wherein the drug retaining substance is a natural high molecular weight compound.
Claim 6
Dependent Claim
16 words
A microcapsule as claimed in claim 4, wherein the natural high molecular weight compound is gelatin.
Claim 7
Dependent Claim
24 words
A microcapsule as claimed in Claim 1, wherein the polymer substance in the oil layer is a copolymer of lactic acid and glycolic acid.
Claim 8
Dependent Claim
16 words
A microcapsule as claimed in Claim 6, wherein the ratio of lactic acid:glyeolic acid is 75:25.
Claim 9
Dependent Claim
14 words
A microcapsule as claimed in claim 1, wherein the inner aqueous layer is solidified.
Claim 10
Dependent Claim
16 words
A microcapsule as claimed in Claim 1, wherein the average diameter is 2 to 200 µm.
Claim 11
Independent Claim
68 words
A method for producing a prolonged release microcapsule of water-soluble drug which comprises preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centipoises and finally subjecting the resulting emulsion to in water drying.
Claim 12
Independent Claim
68 words
A method for producing a prolonged release microcapsule of water-soluble drug which comprises preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centipoises and finally subjecting the resulting emulsion to in water drying.
References Cited (Backward Citations)
No citation records indexed.
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