Osteogenic implants derived from bone

Claim 2

An osteoimplant in the form of a flexible sheet comprising a coherent mass of elongate bone-derived particles possessing a void volume of not greater than 32%.

Claim 3

The osteoimplant of claim 1 containing no appreciable quantity of binder.

Claim 4

The osteoimplant of claim 1 further comprising a plasticizer.

Claim 5

The osteoimplant of claim 3 wherein at least about 60 weight percent of the elongate bone particles possess a median length to median thickness ratio of from about 50:1 to about 100:1, a median length to median width ratio of from about 50:1 to about 100:1.

Claim 6

The osteoimplant of claim 2 further comprising a plasticizer.

Claim 7

The osteoimplant of claim 1 having a density of greater than 0.8 g/cm 3 .

Claim 8

The osteoimplant of claim 2 having a density of greater than 0.8 g/cm 3 .

Claim 9

The osteoimplant of claim 1 further comprising a binder.

Claim 10

The osteoimplant of claim 8 wherein the binder is a bioabsorbable polymeric binder.

Claim 11

The osteoimplant of claim 1 wherein at least about 60 weight percent of the elongate bone particles possess a median length of from about 10 to about 100 mm, a median thickness of from about 0.2 to about 1 mm and a median width of from about 2 to about 5 mm.

Claim 12

The osteoimplant of claim 1 wherein at least about 60 weight percent of the elongate bone particles possess a median length to median thickness ratio of from about 50:1 to about 500:1, a median length to median width ratio of from about 10:1 to about 200:1.

Claim 13

The osteoimplant of claim 1 wherein at least about 60 weight percent of the elongate bone particles possess a median length to median thickness ratio of from about 50:1 to about 100:1, a median length to median width ratio of from about 50:1 to about 100:1.

Claim 14

The osteoimplant of claim 2 wherein at least about 60 weight percent of the elongate bone particles possess a median length to median thickness ratio of from about 50:1 to about 500:1, a median length to median width ratio of from about 10:1 to about 200:1.

Claim 15

The osteoimplant of claim 1 wherein elongate bone particles mechanically adhere to each other.

Claim 16

The osteoimplant of claim 1 wherein elongate bone particles mechanically adhere to each other by entanglement.

Claim 17

The osteoimplant of claim 1 wherein the elongate bone particles are selected from the group consisting of nondemineralized bone particles, demineralized bone particles and mixtures thereof.

Claim 18

The osteoimplant of claim 1 additionally containing bone powder.

Claim 19

The osteoimplant of claim 17 wherein the bone powder is selected from the group consisting of nondemineralized bone powder and demineralized bone powder.

Claim 20

The osteoimplant of claim 1 wherein the elongate bone particles are obtained from cortical, cancellous or cortico-cancellous bone of autogenic, allogenic, xenogenic or transgenic origin.

Claim 21

The osteoimplant of claim 1 wherein the coherent mass is mechanically shaped to a specific three-dimensional architecture.

Claim 22

The osteoimplant of claim 1 shaped as a sheet, plate, disk, tunnel, cone or tube.

Claim 23

The osteoimplant of claim 1 configured for the repair of a simple fracture, compound fracture or non-union; as an external fixation device or internal fixation device; for joint reconstruction, arthrodesis, arthroplasty or cup arthroplasty of the hip; for femoral or humeral head replacement; for femoral head surface replacement or total joint replacement; for repair of the vertebral column, spinal fusion or internal vertebral fixation; for tumor surgery; for deficit filling; for discectomy; for laminectomy; for excision of spinal cord tumors; for an anterior cervical or thoracic operation; for the repairs of a spinal injury; for scoliosis, for lordosis or kyphosis treatment; for intermaxillary fixation of a fracture; for mentoplasty; for temporomandibular joint replacement; for alveolar ridge augmentation and reconstruction; as an inlay osteoimplant; for implant placement and revision; for sinus lift; for a cosmetic procedure; and, for the repair or replacement of the ethmoid, frontal, nasal, occipital, parietal, temporal, mandible, maxilla, zygomatic, cervical vertebra, thoracic vertebra, lumbar vertebra, sacrum, rib, sternum, clavicle, scapula, humerus, radius, ulna, carpal bones, metacarpal bones, phalanges, ilium, ischium, pubis, femur, tibia, fibula, patella, calcaneus, tarsal bones or metatarsal bones.

Claim 24

The osteoimplant of claim 1 further comprising a biocompatible component selected from the group consisting of biocompatible fluid carrier, filler, fiber, mesh, substance providing radiopacity, biostatic/biocidal agent, surface active agent and bioactive substance.

Claim 25

An osteoimplant comprising a coherent mass of elongate bone-derived particles and a binder, said mass possessing a void volume of not greater than 32%.

Claim 26

An osteoimplant comprising a coherent mass of elongate bone-derived particles and a binder, said mass possessing a void volume of not greater than 32%.

Claim 27

The osteoimplant of claim 24 wherein the binder is a bioabsorbable polymeric binder.

Claim 28

The osteoimplant of claim 25 wherein the elongate bone-derived particles are selected from the group consisting of nondemineralized bone particles, demineralized bone particles and mixtures thereof.

Claim 29

The osteoimplant of claim 24 wherein the elongate bone-derived particles mechanically adhere to each other.

Claim 30

The osteoimplant of claim 27 wherein the elongate bone-derived particles are selected from the group consisting of nondemineralized bone particles, demineralized bone particles and mixtures thereof.

Claim 31

The osteoimplant of claim 27 wherein the elongate bone-derived particles mechanically adhere to each other by entanglement.

Claim 32

The osteoimplant of claim 24 wherein the elongate bone-derived particles are selected from the group consisting of nondemineralized bone particles, demineralized bone particles and mixtures thereof.

Claim 33

The osteoimplant of claim 24 further comprising a biocompatible component selected from the group consisting of biocompatible fluid carrier, filler, fiber, mesh, substance providing radiopacity, plasticizer, biostatic/biocidal agent, surface active agent and bioactive substance.