Method of repairing bone tissue

Claim 1

A method for inducing the repair of bone in a warm-blooded vertebrate, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site in said vertebrate in need of repair, said bone graft construct consisting essentially of intestinal submucosal tissue of a warm-blooded vertebrate or a digest thereof in powder form compressed into a pre-determined three-dimensional shape prior to implantation, wherein the compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 2

A method for inducing the repair of bone in a warm-blooded vertebrate, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site in said vertebrate in need of repair, said bone graft construct consisting essentially of intestinal submucosal tissue of a warm-blooded vertebrate or a digest thereof in powder form compressed into a pre-determined three-dimensional shape prior to implantation, wherein the compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 3

A method for including the repair of bone in a warm-blooded vertebrate, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site in said vertebrate in need of repair, said bone graft construct consisting essentially of intestinal submucosal tissue of a warm-blooded vertebrate or a digest thereof in powder form and an added bioactive agent selected from the group consisting of physiological compatible minerals, growth factors, antibiotics, chemotherapeutic agents, antigens, antibodies, enzymes and hormones, wherein said powder bone graft is compressed into a pre-determined three-dimensional shape prior to implantation, and the compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 4

A method for including the repair of bone in a warm-blooded vertebrate, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site in said vertebrate in need of repair, said bone graft construct consisting essentially of intestinal submucosal tissue of a warm-blooded vertebrate or a digest thereof in powder form and an added bioactive agent selected from the group consisting of physiological compatible minerals, growth factors, antibiotics, chemotherapeutic agents, antigens, antibodies, enzymes and hormones, wherein said powder bone graft is compressed into a pre-determined three-dimensional shape prior to implantation, and the compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 5

A method for inducing the repair of bony tissue, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site in said vertebrate in need of repair, said bone graft construct formed by compressing intestinal submucosal tissue or a digest thereof in powder form into a pre-determined three-dimensional shape prior to implantation said intestinal submucosal tissue comprising the tunica submucosa delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of a warm-blooded vertebrate wherein the compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 6

A method for inducing the repair of bony tissue, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site in said vertebrate in need of repair, said bone graft construct formed by compressing intestinal submucosal tissue or a digest thereof in powder form into a pre-determined three-dimensional shape prior to implantation said intestinal submucosal tissue comprising the tunica submucosa delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of a warm-blooded vertebrate wherein the compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 7

A method for inducing the repair of bony tissue, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site of said vertebrate in need of repair, said bone craft construct formed by compressing a composition comprising intestinal submucosal tissue or a digest thereof in powder form and an added bioactive agent into a pre-determined three-dimensional shade prior to implantation, wherein said intestinal submucosal tissue comprises the tunica submucosa delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of a warm-blooded vertebrate, said bioactive agent is selected from the group consisting of physiological compatible minerals, growth factors, antibiotics, chemotherapeutic agents, antigens, antibodies, enzymes and hormones, and said compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.

Claim 8

A method for inducing the repair of bony tissue, said method comprising the step of implanting an effective amount of a biodegradable bone graft construct into a site of said vertebrate in need of repair, said bone craft construct formed by compressing a composition comprising intestinal submucosal tissue or a digest thereof in powder form and an added bioactive agent into a pre-determined three-dimensional shade prior to implantation, wherein said intestinal submucosal tissue comprises the tunica submucosa delaminated from the tunica muscularis and the luminal portion of the tunica mucosa of a warm-blooded vertebrate, said bioactive agent is selected from the group consisting of physiological compatible minerals, growth factors, antibiotics, chemotherapeutic agents, antigens, antibodies, enzymes and hormones, and said compressed powder bone graft maintains its general shape after implantation during the replacement of the graft construct with endogenous tissues.