US4902296A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of demineralized bone matrix in the repair of segmental defects
Assignee: UVA Licensing and Ventures Group
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Filing: 1987-10-29
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Granted: 1990-02-20
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Expires: 2007-10-29
Abstract
Abstract A grafting material comprising milled bone which has an initial coating of guanidine-extracted bone proteins which are dialyzed from solution. Unbound bone proteins are removed and this augmented milled bone is lyophized. A subsequent coat of anti-coagulated plasma containing plasma proteins is applied to the augmented milled bone. The unbound plasma proteins are removed from the coating by rinsing.
Inventors
- 👤 Mark E. Bolander
- 👤 Gary Balian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:02
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/3616; A61L27/3641; A61L27/3645; A61L27/365; A61F2002/2835; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
38 words
Biological grafting material, comprising: milled bone initially coated with guanidine-extracted bone proteins which are dialyzed from solution, wherein unbound bone proteins are removed; and subsequently coated with anti-coagulated plasma containing plasma proteins, wherein unbound plasma proteins are removed.
Claim 2
Dependent Claim
38 words
Biological grafting material, comprising: milled bone initially coated with guanidine-extracted bone proteins which are dialyzed from solution, wherein unbound bone proteins are removed; and subsequently coated with anti-coagulated plasma containing plasma proteins, wherein unbound plasma proteins are removed.
Claim 3
Dependent Claim
18 words
The product of claim 1, wherein the initially coated milled bone with unbound bone proteins removed is lyophized.
Claim 4
Dependent Claim
11 words
The product of claim 1, wherein the bone protein is fibronectin.
Claim 5
Dependent Claim
14 words
The product of claim 1 wherein the milled bone is milled demineralized bone matrix.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-19 | 1993-08-21 | 1994-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-19 | 1997-08-21 | 1998-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-19 | 2001-08-21 | 2002-02-20 | $7700.00 | Window Closed / Lapsed |