US6855169B2
Expired / Lapsed
US
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Demineralized bone-derived implants
Assignee: Synthes USA LLC
•
Filing: 2001-08-13
•
Granted: 2005-02-15
•
Expires: 2021-08-13
Abstract
Abstract Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
Inventors
- 👤 II Michael L. Boyer
- 👤 David C. Paul
- 👤 Christopher M. Angelucci
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:57
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/04; A61B17/0401; A61B17/064; A61B17/0642; A61B17/56; A61B17/58; A61B17/68; A61B17/688; A61B17/70; A61B17/7059; A61B17/7071; A61B17/80; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/2846; A61F2/2875; A61F2/30; A61F2/44; A61F2/4455; A61F2/4465; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61B17/7062; A61B17/8085; A61B2017/0647; A61F2/08; A61F2/2803; A61F2/3094; A61F2/442; A61F2002/2807; A61F2002/2825; A61F2002/2835; A61F2002/2839; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30011; A61F2002/30014; A61F2002/30016; A61F2002/30057; A61F2002/30059; A61F2002/3006; A61F2002/30075; A61F2002/30092; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30125; A61F2002/30126; A61F2002/3013; A61F2002/30131; A61F2002/30138; A61F2002/30143; A61F2002/30153; A61F2002/30154; A61F2002/30159; A61F2002/30166; A61F2002/30169; A61F2002/30172; A61F2002/30199; A61F2002/30224; A61F2002/30233; A61F2002/30235; A61F2002/30261; A61F2002/30291; A61F2002/30293; A61F2002/30316; A61F2002/30317; A61F2002/30324; A61F2002/30329; A61F2002/30383; A61F2002/30387; A61F2002/30433; A61F2002/30462; A61F2002/30535; A61F2002/30576; A61F2002/30578; A61F2002/30593; A61F2002/30594; A61F2/30767; A61F2/30771; A61F2002/30772; A61F2002/30784; A61F2002/30785; A61F2002/30787; A61F2002/3082; A61F2002/30827; A61F2002/30828; A61F2002/30841; A61F2002/30843; A61F2002/30878; A61F2002/30879; A61F2002/30891; A61F2002/30892; A61F2002/30904; A61F2/30907; A61F2002/30909; A61F2002/30914; A61F2002/30971; A61F2002/30973; A61F2002/4415; A61F2002/444; A61F2/46; A61F2/4644; A61F2002/4649; A61F2210/00; A61F2210/0014; A61F2210/0061; A61F2220/00; A61F2220/0025; A61F2220/0041; A61F2220/0075; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0008; A61F2230/001; A61F2230/0013; A61F2230/0017; A61F2230/0019; A61F2230/0021; A61F2230/0028; A61F2230/0047; A61F2230/0052; A61F2230/0063; A61F2230/0069; A61F2230/0082; A61F2230/0091; A61F2250/00; A61F2250/0014; A61F2250/0018; A61F2250/0019; A61F2250/0023; A61F2250/0029; A61F2250/0036; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00017; A61F2310/00023; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/919
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
55 words
A bone sheet for implanation, the sheet having a top surface, a bottom surface and a plurality of side surfaces extending therebetween, the sheet further comprising an at least partially demineralized field substantially surrounding at least one mineralized region, wherein the at least one mineralized region extends from the top surface to the bottom surface.
Claim 2
Dependent Claim
55 words
A bone sheet for implanation, the sheet having a top surface, a bottom surface and a plurality of side surfaces extending therebetween, the sheet further comprising an at least partially demineralized field substantially surrounding at least one mineralized region, wherein the at least one mineralized region extends from the top surface to the bottom surface.
Claim 3
Dependent Claim
19 words
The bone sheet according to claim 1 , having at least one rib providing localized thickness to the sheet.
Claim 4
Dependent Claim
16 words
The bone sheet according to claim 1 , wherein the sheet is formed of cortical bone.
Claim 5
Dependent Claim
17 words
The bone sheet according to claim 3 , wherein the sheet comprises a plurality of mineralized regions.
Claim 6
Dependent Claim
21 words
The bone sheet according to claim 4 , wherein at least two of the mineralized regions are connected by a strut.
Claim 7
Dependent Claim
23 words
The bone sheet according to claim 3 , wherein the at least one mineralized region defines at least one hole in the sheet.
Claim 8
Dependent Claim
24 words
The bone sheet according to claim 6 , wherein the at least one hole is configured and dimensioned to receive at least one fastener.
Claim 9
Dependent Claim
23 words
The bone sheet according to claim 3 , wherein the sheet has a thickness of between about 0.5 mm and about 3 mm.
Claim 10
Independent Claim
66 words
A method of forming a flexible bone sheet comprising: providing a sheet of cortical bone; creating at least one hole in the cortical sheet which is configured and dimensioned to receive a fastener; masking the cortical sheet proximate the at least one hole to create a masked region surrounding the at least one hole; and applying demineralizing agents to the cortical sheet around the masked region.
Claim 11
Independent Claim
66 words
A method of forming a flexible bone sheet comprising: providing a sheet of cortical bone; creating at least one hole in the cortical sheet which is configured and dimensioned to receive a fastener; masking the cortical sheet proximate the at least one hole to create a masked region surrounding the at least one hole; and applying demineralizing agents to the cortical sheet around the masked region.
Claim 12
Dependent Claim
28 words
The method according to claim 9 , wherein a plurality of masking elements are removably attached to the sheet to provide masking proximate the at least one hole.
Claim 13
Dependent Claim
26 words
The method according to claim 9 , wherein the masking is provided by at least one of the group consisting of tape, paint, and a coating.
Claim 14
Dependent Claim
24 words
The method according to claim 9 , further comprising creating perforations in the sheet that are substantially smaller than the at least one hole.
Claim 15
Dependent Claim
17 words
The method according to claim 9 , further comprising cutting a bone section along a spiral path.
Claim 16
Independent Claim
66 words
A method of forming a flexible bone sheet comprising: providing a sheet of cortical bone; creating at least one hole in the sheet which is configured and dimensioned to receive a fastener; masking the sheet proximate the at least one hole to create a masked region surrounding the at least one hole; and applying at least one demineralized agent to the sheet around the masked region.
Claim 17
Independent Claim
66 words
A method of forming a flexible bone sheet comprising: providing a sheet of cortical bone; creating at least one hole in the sheet which is configured and dimensioned to receive a fastener; masking the sheet proximate the at least one hole to create a masked region surrounding the at least one hole; and applying at least one demineralized agent to the sheet around the masked region.
Claim 18
Dependent Claim
33 words
The method according to claim 14 , wherein the masking at least partially comprises: removably attaching a plurality of masking elements to the sheet to provide masking proximate the at least one hole.
Claim 19
Dependent Claim
24 words
The method according to claim 14 , further comprising: creating perforations in the sheet that are substantially smaller than the at least one hole.
Claim 20
Dependent Claim
21 words
The method according to claim 14 , further comprising: masking the sheet proximate at least a portion of an edge thereof.
Claim 21
Dependent Claim
85 words
A bone sheet for implantation, the sheet having a top surface, a bottom surface, and a plurality of side surfaces, the sheet further comprising: a flexible and at least partially demineralized field extending from the top surface to the bottom surface; at least one mineralized region extending from the top surface to the bottom surface, the at least one mineralized region being substantially surrounded by the at least partially demineralized field; and at least one hole configured and dimensioned to receive at least one fastener.
Claim 22
Dependent Claim
85 words
A bone sheet for implantation, the sheet having a top surface, a bottom surface, and a plurality of side surfaces, the sheet further comprising: a flexible and at least partially demineralized field extending from the top surface to the bottom surface; at least one mineralized region extending from the top surface to the bottom surface, the at least one mineralized region being substantially surrounded by the at least partially demineralized field; and at least one hole configured and dimensioned to receive at least one fastener.
Claim 23
Dependent Claim
14 words
The bone sheet according to claim 18 , wherein the sheet comprises cortical bone.
Claim 24
Dependent Claim
20 words
The bone sheet according to claim 18 , wherein the at least one mineralized region consists essentially of cortical bone.
Claim 25
Dependent Claim
23 words
The bone sheet according to claim 18 , wherein the at least one hole is defined within the at least one mineralized region.
Claim 26
Dependent Claim
26 words
The bone sheet according to claim 18 , wherein the sheet comprises at least two holes and the mineralized region extends between at least two holes.
Claim 27
Dependent Claim
18 words
The bone sheet according to claim 18 , wherein the mineralized region extends between at least three holes.
Claim 28
Dependent Claim
26 words
The bone sheet according to claim 18 , further comprising an outer edge of the bone sheet, wherein the mineralized region extends to the outer edge.
Claim 29
Dependent Claim
43 words
A mesh for implantation comprising: a perforated cortical bone sheet comprising a plurality of openings; at least one mineralized region disposed around at least one of the openings; and an at least partially demineralized region disposed around the at least one mineralized region.
Claim 30
Dependent Claim
43 words
A mesh for implantation comprising: a perforated cortical bone sheet comprising a plurality of openings; at least one mineralized region disposed around at least one of the openings; and an at least partially demineralized region disposed around the at least one mineralized region.
Claim 31
Dependent Claim
85 words
A bone sheet for implantation, the sheet having a top surface, a bottom surface and a plurality of side surfaces, the bone sheet further comprising an at least partially demineralized field and at least one mineralized region having a mineralized top surface, a mineralized bottom surface, and at least one side surface; wherein the at least one mineralized region extends from the top surface to the bottom surface and is substantially surrounded by the at least partially demineralized field along the least one side surface.
Claim 32
Dependent Claim
85 words
A bone sheet for implantation, the sheet having a top surface, a bottom surface and a plurality of side surfaces, the bone sheet further comprising an at least partially demineralized field and at least one mineralized region having a mineralized top surface, a mineralized bottom surface, and at least one side surface; wherein the at least one mineralized region extends from the top surface to the bottom surface and is substantially surrounded by the at least partially demineralized field along the least one side surface.
Claim 33
Dependent Claim
95 words
A bone sheet for implantation, the sheet having a top surface, a bottom surface, and a plurality of side surfaces, the sheet further comprising: a flexible and at least partially demineralized field; at least one mineralized region having a mineralized top surface, a mineralized bottom surface, and at least one mineralized side surface, wherein the mineralized region extends from the top surface to the bottom surface and the mineralized side surface is substantially surrounded by the at least partially demineralized field; and at least one hole configured and dimensioned to receive at least one fastener.
Claim 34
Dependent Claim
95 words
A bone sheet for implantation, the sheet having a top surface, a bottom surface, and a plurality of side surfaces, the sheet further comprising: a flexible and at least partially demineralized field; at least one mineralized region having a mineralized top surface, a mineralized bottom surface, and at least one mineralized side surface, wherein the mineralized region extends from the top surface to the bottom surface and the mineralized side surface is substantially surrounded by the at least partially demineralized field; and at least one hole configured and dimensioned to receive at least one fastener.
References Cited (Backward Citations)
US2621145A
Cited
US4512038A
Cited
US4932973A
Cited
US5053049A
Cited
US4627853A
Cited
US4863472A
Cited
SU1465040A1
Cited
US5258043A
Cited
US5222987A
Cited
US4994084A
Cited
US5439684A
Cited
US5284655A
Cited
US5298254A
Cited
US5676699A
Cited
US5306304A
Cited
US5464439A
Cited
US5556430A
Cited
US5314476A
Cited
US5569308A
Cited
US5507813A
Cited
US6110482A
Cited
US5904716A
Cited
US5733288A
Cited
WO1997025941A1
Cited
US6436138B1
Cited
US5868749A
Cited
US5968047A
Cited
US5676146B1
Cited
US5676146A
Cited
US5728159A
Cited
US5976187A
Cited
US6090998A
Cited
US5899939A
Cited
WO1999038461A2
Cited
WO1999039757A1
Cited
US6123731A
Cited
WO2000007527A1
Cited
WO2000007528A1
Cited
WO2000030568A1
Cited
US20010014831A1
Cited
US6200347B1
Cited
WO2000040177A1
Cited
US6458158B1
Cited
WO2000040179A1
Cited
US6206923B1
Cited
US20010010021A1
Cited
US20020106393A1
Cited
US6432436B1
Cited
US20020091447A1
Cited
US20020107570A1
Cited
US20020107571A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2008-02-15 | 2008-08-16 | 2009-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2012-02-15 | 2012-08-16 | 2013-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2016-02-15 | 2016-08-16 | 2017-02-15 | $7700.00 | Window Closed / Lapsed |