US20010014831A1
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Bone graft, method of making bone graft and guided bone regeneration method
Assignee: Warsaw Orthopedic Inc
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Filing: 2001-03-16
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Granted: —
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Expires: 2021-03-16
Abstract
Abstract An implantable, biocompatible, osteogenic bone graft comprises at least one zone of impermeability to soft tissue ingrowth which is integral with the bone graft. Application of the bone graft to a bone repair site leads to selective rapid new bone ingrowth and inhibits or prevents soft tissue, e.g., gingival, epithelial, connective and/or muscle tissue, ingrowth in those areas adjacent to the zone(s) of impermeability to soft tissue ingrowth. The bone graft can be employed in a wide variety of bone repair procedures.
Inventors
- 👤 Nelson Scarborough
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
86 words
1 . An implantable, biocompatible osteogenic bone graft comprising a coherent mass of bone particles possessing at least one zone of impermeability to soft tissue ingrowth, said zone of impermeability being a porous region of the coherent mass of bone particles possessing pores having an average pore size which substantially prevents the ingrowth of bone tissue, wherein said zone is integral with the bone graft, such that the zone of impermeability and the bone graft are indivisibly connected so as to form a single unified whole.
Claim 2
Dependent Claim
86 words
1 . An implantable, biocompatible osteogenic bone graft comprising a coherent mass of bone particles possessing at least one zone of impermeability to soft tissue ingrowth, said zone of impermeability being a porous region of the coherent mass of bone particles possessing pores having an average pore size which substantially prevents the ingrowth of bone tissue, wherein said zone is integral with the bone graft, such that the zone of impermeability and the bone graft are indivisibly connected so as to form a single unified whole.
Claim 3
Dependent Claim
37 words
2 . The bone graft of claim 1 wherein the coherent mass of bone particles is configured and dimensioned in the shape of a tooth, tooth root, sheet, plate, disk, tunnel, ring, cone, pin, screw or tube.
Claim 4
Dependent Claim
25 words
3 . The bone graft of claim 1 wherein the bone particles comprise from about 20 to about 100 weight percent of the coherent mass.
Claim 5
Dependent Claim
25 words
4 . The bone graft of claim 1 wherein the bone particles comprise from about 30 to about 90 weight percent of the coherent mass.
Claim 6
Dependent Claim
25 words
5 . The bone graft of claim 1 wherein the bone particles comprise from about 40 to about 85 weight percent of the coherent mass.
Claim 7
Dependent Claim
14 words
6 . The bone graft of claim 1 wherein the bone particles are demineralized.
Claim 8
Dependent Claim
35 words
7 . The bone graft of claim 6 wherein the demineralized bone particles are selected from the group consisting of superficially demineralized bone particles, partially demineralized bone particles, fully demineralized bone particles and mixtures thereof.
Claim 9
Dependent Claim
33 words
8 . The bone graft of claim 1 wherein the bone particles are obtained from cortical, cancellous or cortico-cancellous types of bone, said types of bone being of autogenous, allogenic or xenogeneic origin.
Claim 10
Dependent Claim
19 words
9 . The bone graft of claim 1 wherein the bone particles are obtained from porcine or bovine bone.
Claim 11
Dependent Claim
14 words
10 . The bone graft of claim 1 wherein the bone particles are powdered.
Claim 12
Dependent Claim
57 words
11 . The bone graft of claim 1 wherein at least about 60 weight percent of the bone particles possess a median length of from about 10 mm to about 100 mm, a median thickness of from about 0.02 mm to about 1 mm and a median width of from about 2 mm to about 5 mm.
Claim 13
Dependent Claim
35 words
12 . The bone graft of claim 1 wherein the coherent mass further contains one or more substances selected from the group consisting of binders, fillers, plasticizers, biostatic agents, biocidal agents and surface active agents.
Claim 14
Dependent Claim
19 words
13 . The bone graft of claim 1 wherein the coherent mass further contains at least one bioactive substance.
Claim 15
Dependent Claim
22 words
14 . The bone graft of claim 1 where the coherent mass possesses a consistency which is shape sustaining but readily deformable.
Claim 16
Dependent Claim
27 words
15 . The bone graft of claim 1 wherein the coherent mass is rigid and relatively strong when dry and flexible and pliable when wetted or hydrated.
Claim 17
Dependent Claim
61 words
16 . A method of making a bone graft which comprises: providing a coherent mass of bone particles, said coherent mass of bone particles possessing a surface region; and occluding a portion of the surface region of the coherent mass to provide at least one zone of impermeability to soft tissue ingrowth wherein said zone is integral with the bone graft.
Claim 18
Dependent Claim
61 words
16 . A method of making a bone graft which comprises: providing a coherent mass of bone particles, said coherent mass of bone particles possessing a surface region; and occluding a portion of the surface region of the coherent mass to provide at least one zone of impermeability to soft tissue ingrowth wherein said zone is integral with the bone graft.
Claim 19
Dependent Claim
22 words
17 . The method of claim 16 wherein the occluding step comprises heating a portion of the surface area at elevated temperature.
Claim 20
Dependent Claim
19 words
18 . The method of claim 17 wherein the elevated temperature ranges from about 40 to about 80° C.
Claim 21
Dependent Claim
19 words
19 . The method of claim 17 wherein the heating is conducted for about 1 to about 60 minutes.
Claim 22
Dependent Claim
28 words
20 . The method of claim 17 wherein the heating is conducted by contacting a portion of the surface area of the coherent mass with a heated surface.
Claim 23
Dependent Claim
26 words
21 . The method of claim 16 wherein the occluding step comprises crosslinking bone particles at a portion of the surface area of the coherent mass.
Claim 24
Dependent Claim
29 words
22 . The method of claim 21 wherein crosslinking is conducted by chemical reaction, application of radiant energy, drying and/or heating and dye-mediated photo-oxidation, dehydrothermal treatment or enzymatic treatment.
Claim 25
Dependent Claim
22 words
23 . The method of claim 21 wherein crosslinking is conducted by contacting the coherent mass with a solution containing crosslinking agent.
Claim 26
Dependent Claim
57 words
24 . The method of claim 23 wherein the crosslinking agent is selected from the group consisting of mono- and dialdehydes, polyepoxy compounds, tanning agents, polyvalent metallic oxides, chemicals for esterification of carboxyl groups followed by reaction with hydrazide to form activated acyl azide functionalities, dicyclohexyl carbodiimide and its derivatives, heterobifunctional crosslinking agents, hexamethylene diisocyante and sugars.
Claim 27
Dependent Claim
35 words
25 . The method of claim 16 wherein the occluding step comprises applying one or more biocompatible substances to a portion of the surface area of the coherent mass to provide a microporous layer thereon.
Claim 28
Dependent Claim
105 words
26 . A process for guided bone regeneration which comprises: providing an implantable, biocompaatible osteogenic bone graft comprising a coherent mass of bone particles possessing at least one zone of impermeability to soft tissue ingrowth, said zone of impermeability being a porous region of the coherent mass of bone particles possessing pores having an average pore size which substantially prevents the ingrowth of bone tissue, wherein the zone is integral with the bone graft such that the zone of impermeability and the bone graft are indivisibly connected so as to form a single, unified whole; and applying the bone graft to a bone repair site.
Claim 29
Dependent Claim
105 words
26 . A process for guided bone regeneration which comprises: providing an implantable, biocompaatible osteogenic bone graft comprising a coherent mass of bone particles possessing at least one zone of impermeability to soft tissue ingrowth, said zone of impermeability being a porous region of the coherent mass of bone particles possessing pores having an average pore size which substantially prevents the ingrowth of bone tissue, wherein the zone is integral with the bone graft such that the zone of impermeability and the bone graft are indivisibly connected so as to form a single, unified whole; and applying the bone graft to a bone repair site.
Claim 30
Dependent Claim
24 words
27 . The process of claim 26 wherein the bone particles comprise from about 20 to about 100 weight percent of the coherent mass.
Claim 31
Dependent Claim
24 words
28 . The process of claim 26 wherein the bone particles comprise from about 30 to about 90 weight percent of the coherent mass.
Claim 32
Dependent Claim
24 words
29 . The process of claim 26 wherein the bone particles comprise from about 40 to about 85 weight percent of the coherent mass.
Claim 33
Dependent Claim
13 words
30 . The process of claim 26 wherein the bone particles are demineralized.
Claim 34
Dependent Claim
34 words
31 . The process of claim 30 wherein the demineralized bone particles are selected from the group consisting of superficially demineralized bone particles, partially demineralized bone particles, fully demineralized bone particles and mixtures thereof.
Claim 35
Dependent Claim
32 words
32 . The process of claim 26 wherein the bone particles are obtained from cortical, cancellous or cortico-cancellous types of bone, said types of bone being of autogenous, allogenic or xenogeneic origin.
Claim 36
Dependent Claim
18 words
33 . The process of claim 26 wherein the bone particles are obtained from porcine or bovine bone.
Claim 37
Dependent Claim
13 words
34 . The process of claim 26 wherein the bone particles are powdered.
Claim 38
Dependent Claim
56 words
35 . The process of claim 26 wherein at least about 60 weight percent of the bone particles possess a median length of from about 10 mm to about 100 mm, a median thickness of from about 0.02 mm to about 1 mm and a median width of from about 2 mm to about 5 mm.
Claim 39
Dependent Claim
34 words
36 . The process of claim 26 wherein the coherent mass further contains one or more substances selected from the group consisting of binders, fillers, plasticizers, biostatic agents, biocidal agents and surface active agents.
Claim 40
Dependent Claim
17 words
37 . The process of claim 26 wherein the coherent mass contains at least one bioactive substance.
Claim 41
Dependent Claim
21 words
48 . The process of claim 26 where the coherent mass possesses a consistency which is shape sustaining but readily deformable.
Claim 42
Dependent Claim
26 words
39 . The process of claim 26 wherein the coherent mass is rigid and relatively strong when dry and flexible and pliable when wetted or hydrated.
Claim 43
Dependent Claim
33 words
40 . The process of claim 26 wherein the bone graft is configured and dimensioned in the shape of a tooth, tooth root, sheet, plate, disk, tunnel, ring, cone, pin, screw or tube.
Claim 44
Dependent Claim
22 words
41 . The process of claim 26 wherein the coherent mass is configured and dimensioned to fit inside a tooth extraction socket.
Claim 45
Dependent Claim
23 words
42 . The process of claim 26 wherein the bone repair site is a site associated with surgery, infection, malignancy or developmental malformation.
Claim 46
Dependent Claim
23 words
43 . The process of claim 26 wherein the bone repair site is an orthopaedic, periodontal, neurosurgical, oral or maxillofacial bone repair site.
Claim 47
Dependent Claim
18 words
44 . The process of claim 26 wherein the bone repair site is a periodontal bone repair site.
Claim 48
Dependent Claim
21 words
45 . The process of claim 44 wherein the bone graft is in the shape of a tooth or tooth root.
References Cited (Backward Citations)
No citation records indexed.
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