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US6312374B1 Expired / Lapsed US ⏱️ 0.0 years remaining

Radioactive wire placement catheter

Assignee: Progenix LLC
•
Filing: 1999-09-29
•
Granted: 2001-11-06
•
Expires: 2019-09-29
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Abstract

Abstract Disclosed is a closed lumen catheter for facilitating placement of a radiation source within a vessel. A distal portion of at least a first lumen and a second lumen are separated by a moveable wall, allowing a reduced catheter shaft profile. Centering structures, such as one or more inflatable balloons, with perfusion, may be added. Methods are also disclosed.

Inventors

  • 👤 Gerard von Hoffmann

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 18:44
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/104; A61M2025/0004; A61M25/0021; A61M25/0023; A61M2025/0025; A61M25/0043; A61M2025/0063; A61M2025/1043; A61M2025/1079

Claims Analysis

Total Claims: 32
Claim 1
Independent Claim 117 words
A method of delivering radiation to a site within a patient, comprising the steps of: providing a catheter having a distal section in which a first lumen and a second lumen are separated by a flexible wall; advancing a guidewire through the patient to the site; advancing the catheter along the guidewire to the site, with the guidewire extending through the second lumen, wherein the first lumen, second lumen and guidewire are dimensioned such that when the guidewire is positioned within the second lumen, the first lumen is substantially collapsed; withdrawing the guidewire proximally from at least the distal section of the catheter; and introducing a radiation delivery wire through the first lumen to treat the site.
Claim 2
Independent Claim 117 words
A method of delivering radiation to a site within a patient, comprising the steps of: providing a catheter having a distal section in which a first lumen and a second lumen are separated by a flexible wall; advancing a guidewire through the patient to the site; advancing the catheter along the guidewire to the site, with the guidewire extending through the second lumen, wherein the first lumen, second lumen and guidewire are dimensioned such that when the guidewire is positioned within the second lumen, the first lumen is substantially collapsed; withdrawing the guidewire proximally from at least the distal section of the catheter; and introducing a radiation delivery wire through the first lumen to treat the site.
Claim 3
Dependent Claim 52 words
A method as in claim 1 , wherein the catheter comprises a transition between the proximal section and the distal section, and the withdrawing the guidewire step comprises withdrawing the distal end of the guidewire to a position between the distal end of the transition and the proximal end of the catheter.
Claim 4
Dependent Claim 43 words
A method as in claim 2 , wherein the withdrawing the guidewire step comprises withdrawing the distal end of the guidewire to a point within the range of from about 3 cm to about 40 cm from the distal end of the catheter.
Claim 5
Dependent Claim 43 words
A method as in claim 3 , wherein the withdrawing the guidewire step comprises withdrawing the distal end of the guidewire to a point within the range of from about 5 cm to about 20 cm from the distal end of the catheter.
Claim 6
Dependent Claim 30 words
A method as in claim 1 , further comprising the steps of retracting the radiation delivery wire from the distal section, and readvancing the guidewire distally through the distal section.
Claim 7
Dependent Claim 26 words
A method as in claim 1 , further comprising the step of proximally withdrawing the catheter from the patient while leaving the guidewire at the site.
Claim 8
Independent Claim 81 words
A method of positioning a radiation source at a site within a patient, comprising the steps of: providing a catheter having a guidewire lumen and a radiation delivery lumen; advancing the catheter along a guidewire to the site; retracting the guidewire such that at least a distal portion of the catheter extends distally beyond a distal end of the guidewire; collapsing the guidewire lumen in the distal portion of the catheter; and introducing the radiation source into the radiation delivery lumen.
Claim 9
Independent Claim 81 words
A method of positioning a radiation source at a site within a patient, comprising the steps of: providing a catheter having a guidewire lumen and a radiation delivery lumen; advancing the catheter along a guidewire to the site; retracting the guidewire such that at least a distal portion of the catheter extends distally beyond a distal end of the guidewire; collapsing the guidewire lumen in the distal portion of the catheter; and introducing the radiation source into the radiation delivery lumen.
Claim 10
Dependent Claim 16 words
A method as in claim 7 , wherein the radiation lumen has a closed distal end.
Claim 11
Dependent Claim 16 words
A method as in claim 7 , wherein the radiation source is carried by a wire.
Claim 12
Dependent Claim 28 words
A method as in claim 7 , wherein the guidewire lumen in the distal portion of the catheter collapses in response to distal advancement of the radiation source.
Claim 13
Dependent Claim 38 words
A method as in claim 7 , further comprising the steps of proximally retracting the radiation source and distally advancing the guidewire so that the distal end of the guidewire extends beyond the distal end of the catheter.
Claim 14
Dependent Claim 25 words
A method as in claim 11 , further comprising the step of retracting the catheter from the patient while leaving the guidewire across the site.
Claim 15
Dependent Claim 24 words
A method as in claim 12 , further comprising the step of advancing a second catheter along the guidewire to further treat the site.
Claim 16
Dependent Claim 119 words
A radiation delivery catheter for temporarily placing an isotope at a treatment site within a patient, comprising: an elongate, flexible body, having a proximal end and a distal end; a transition within the range of from about 2cm to about 50 cm from the distal end; and at least a guidewire lumen and a radiation source wire lumen in the body, distal of the transition, the guidewire lumen and the radiation source wire lumen separated by a flexible wall; wherein the flexible wall is movable between a first position to allow a guidewire to be advanced through the guidewire lumen, and a second position to allow a radiation source wire to be advanced through the radiation source wire lumen.
Claim 17
Dependent Claim 119 words
A radiation delivery catheter for temporarily placing an isotope at a treatment site within a patient, comprising: an elongate, flexible body, having a proximal end and a distal end; a transition within the range of from about 2cm to about 50 cm from the distal end; and at least a guidewire lumen and a radiation source wire lumen in the body, distal of the transition, the guidewire lumen and the radiation source wire lumen separated by a flexible wall; wherein the flexible wall is movable between a first position to allow a guidewire to be advanced through the guidewire lumen, and a second position to allow a radiation source wire to be advanced through the radiation source wire lumen.
Claim 18
Dependent Claim 58 words
A radiation delivery catheter as in claim 14 , wherein the outside diameter of the catheter distal of the transition is no more than about 110% of the sum of the diameters of the guidewire lumen when the wall is in the first position and the radiation source wire lumen when the wall is in the second position.
Claim 19
Dependent Claim 56 words
A radiation delivery catheter as in claim 15 , wherein the outside diameter of the catheter distal of the transition is no more than about the sum of the diameters of the guidewire lumen when the wall is in the first position and the radiation source wire lumen when the wall is in the second position.
Claim 20
Dependent Claim 42 words
A radiation delivery catheter as in claim 14 , wherein the tubular body comprises a tubular outer wall defining an interior, and the interior is divided into at least the guidewire lumen and the radiation source wire lumen by the flexible wall.
Claim 21
Dependent Claim 71 words
A radiation delivery catheter as in claim 17 , wherein at a cross section through the catheter a first lateral end of the flexible wall is connected to the outer wall at a first point and a second lateral end of the flexible wall is connected to the outer wall a second point to define the guidewire lumen and the radiation source wire lumen on either side of the flexible wall.
Claim 22
Dependent Claim 39 words
A radiation delivery catheter as in claim 18 , wherein the lateral width of the flexible wall from the first point to the second point is greater than the linear distance between the first point and the second point.
Claim 23
Dependent Claim 29 words
A radiation delivery catheter as in claim 19 , wherein the width is at least about 115% of the linear distance between the first point and the second point.
Claim 24
Dependent Claim 29 words
A radiation delivery catheter as in claim 19 , wherein the width is at least about 130% of the linear distance between the first point and the second point.
Claim 25
Dependent Claim 30 words
A radiation delivery catheter as in claim 14 , further comprising an afterloader removably coupled to the proximal end, for advancing a radioactive wire through the radiation source wire lumen.
Claim 26
Dependent Claim 18 words
A radiation delivery catheter as in claim 14 , further comprising a centering element near the distal end.
Claim 27
Dependent Claim 19 words
A radiation delivery catheter as in claim 23 , wherein the centering element comprises at least one inflatable balloon.
Claim 28
Dependent Claim 38 words
A radiation delivery catheter as in claim 24 , wherein the centering element comprises at least two inflatable balloons, arranged to center at least a portion of the catheter in a vessel and permit perfusion through the vessel.
Claim 29
Independent Claim 51 words
A method of delivering a dose of radiation to a site in a vessel, comprising the steps of: advancing a catheter along a guidewire to a site in a vessel; partially retracting the guidewire from the catheter, and distally advancing a radioactive source wire through the catheter to treat the site.
Claim 30
Independent Claim 51 words
A method of delivering a dose of radiation to a site in a vessel, comprising the steps of: advancing a catheter along a guidewire to a site in a vessel; partially retracting the guidewire from the catheter, and distally advancing a radioactive source wire through the catheter to treat the site.
Claim 31
Dependent Claim 29 words
A method of delivering a dose of radiation as in claim 26 , wherein the proximally retracting the guidewire step comprises retracting the guidewire until a visible indicium appears.
Claim 32
Dependent Claim 39 words
A method of delivering a dose of radiation as in claim 27 , wherein the proximally retracting the guidewire step comprises retracting the guidewire until a color change appears on the guidewire at a proximal end of the catheter.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2004-11-05 2005-05-07 2005-11-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2008-11-05 2009-05-07 2009-11-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2012-11-05 2013-05-07 2013-11-06 $7700.00 Window Closed / Lapsed

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