Irradiation catheter and method of use

Claim 2

An irradiation catheter assembly for disposing a nuclear irradiation source at a selected position in a blood vessel, comprising: a flexible tubular catheter body having an inner lumen; an elongated irradiation ribbon disposed within said lumen; at least one radioactive element mounted on said ribbon; a guidewire channel formed on said catheter body; and a guidewire disposed within said guidewire channel for guiding said catheter body to a selected site within the blood vessel.

Claim 3

An irradiation catheter assembly as claimed in claim 1, further comprising an expandable wire structure mounted on said catheter body, for radially positioning said radioactive element.

Claim 4

An irradiation catheter assembly as claimed in claim 2, wherein said expandable wire structure comprises: a plurality of flexible wire loops, each of said wire loops having a first end attached to said catheter body; flexing means attached to a second end of each of said wire loops, said flexing means being selectively movable by a user to move said second ends of said wire loops toward said first ends to flex said wire loops radially outwardly, thereby positioning said radioactive element as desired relative to the walls of the blood vessel.

Claim 5

An irradiation catheter assembly as claimed in claim 1, wherein a portion of said guidewire channel is formed near a distal end of said catheter body to enable use of said catheter body as a rapid exchange catheter, and further comprising a second guidewire channel portion formed near a proximal end of said catheter body to provide a sealing surface around the perimeter of said body for encircling said guidewire.

Claim 6

An irradiation catheter assembly as claimed in claim 1, further comprising: at least one balloon mounted on said catheter body, said balloon being inflatable to radially extend at least one extremity of said balloon from said catheter body to position said radioactive element as desired relative to the walls of the blood vessel; and an inflation lumen formed on said catheter body, said inflation lumen being connected in flow communication with said balloon for providing inflation pressure to said balloon.

Claim 7

An irradiation catheter assembly for disposing a nuclear irradiation source at a selected position in a blood vessel, comprising: a flexible tubular catheter body having an inner lumen; an elongated irradiation ribbon disposed within said lumen; at least one radioactive element disposed near a distal end of said ribbon; a guidewire channel formed adjacent a distal end of said catheter body; a guidewire disposed within said guidewire channel for guiding said catheter body to a selected site within the blood vessel; a closed distal end formed on said inner lumen to retain said radioactive element within said lumen; and an expandable centering means mounted on said catheter body adjacent said radioactive element, for selectively centering said catheter body radially within the blood vessel.

Claim 8

An irradiation catheter assembly for disposing a nuclear irradiation source at a selected position in a blood vessel, comprising: a flexible tubular catheter body having an inner lumen; an elongated irradiation ribbon disposed within said lumen; at least one radioactive element disposed near a distal end of said ribbon; a guidewire channel formed adjacent a distal end of said catheter body; a guidewire disposed within said guidewire channel for guiding said catheter body to a selected site within the blood vessel; a closed distal end formed on said inner lumen to retain said radioactive element within said lumen; and an expandable centering means mounted on said catheter body adjacent said radioactive element, for selectively centering said catheter body radially within the blood vessel.

Claim 9

An irradiation catheter assembly as claimed in claim 6, wherein said centering means comprises an expandable wire structure.

Claim 10

An irradiation catheter assembly as claimed in claim 7, wherein said expandable wire structure comprises: a plurality of flexible wire loops, each of said wire loops having a first end attached to said catheter body; flexing means attached to a second end of each of said wire loops, said flexing means being selectively movable by a user to move said second ends of said wire loops toward said first ends to flex said wire loops radially outwardly, thereby centering said body relative to the walls of the blood vessel.

Claim 11

An irradiation catheter assembly as claimed in claim 6, wherein said centering means comprises: at least one balloon mounted on said catheter body, said balloon being selectively inflatable to radially extend at least one extremity of said balloon from said catheter body to radially center said catheter body relative to the walls of the blood vessel; and an inflation lumen formed on said catheter body, said inflation lumen being connected in flow communication with said balloon for providing inflation pressure to said balloon.

Claim 12

A catheter for disposing a nuclear irradiation source at a selected position in a blood vessel over a guidewire, said catheter comprising: a flexible tubular body having an inner lumen for receiving the irradiation source; a guidewire channel formed on said body for receiving the guidewire; a positioning means mounted on said body adjacent the intended position of the irradiation source, for positioning said body radially as desired within the blood vessel; and a closed distal end formed on said inner lumen to retain the irradiation source within said lumen; wherein said positioning means comprises: at least one balloon mounted on said body, said balloon being inflatable to radially extend at least one extremity of said balloon from said body to position said body as desired relative to the walls of the blood vessel; and an inflation lumen formed on said body, said inflation lumen being connected in flow communication with said balloon for providing inflation pressure to said balloon; wherein said at least one balloon comprises an inflatable coil surrounding said body.

Claim 13

A catheter for disposing a nuclear irradiation source at a selected position in a blood vessel over a guidewire, said catheter comprising: a flexible tubular body having an inner lumen for receiving the irradiation source; a guidewire channel formed on said body for receiving the guidewire; a positioning means mounted on said body adjacent the intended position of the irradiation source, for positioning said body radially as desired within the blood vessel; and a closed distal end formed on said inner lumen to retain the irradiation source within said lumen; wherein said positioning means comprises: at least one balloon mounted on said body, said balloon being inflatable to radially extend at least one extremity of said balloon from said body to position said body as desired relative to the walls of the blood vessel; and an inflation lumen formed on said body, said inflation lumen being connected in flow communication with said balloon for providing inflation pressure to said balloon; wherein said at least one balloon comprises an inflatable coil surrounding said body.

Claim 14

A catheter as claimed in claim 10, wherein said inflatable coil comprises a plurality of loops having a substantially constant diameter.

Claim 15

A catheter for disposing a nuclear irradiation source at a selected position in a blood vessel over a guidewire, said catheter comprising; a flexible tubular body having an inner lumen for receiving the irradiation source; a guidewire channel formed on said body for receiving the guidewire; a positioning means mounted on said body adjacent the intended position of the irradiation source, for positioning said body radially as desired within the blood vessel; and a closed distal end formed on said inner lumen to retain the irradiation source within said lumen; wherein said positioning means comprises: at least one balloon mounted on said body, said balloon being inflatable to radially extend at least one extremity of said balloon from said body to position said body as desired relative to the walls of the blood vessel; and an inflation lumen formed on said body, said inflation lumen being connected in flow communication with said balloon for providing inflation pressure to said balloon; wherein said at least one balloon comprises at least one substantially annular balloon surrounding said body.

Claim 16

A catheter for disposing a nuclear irradiation source at a selected position in a blood vessel over a guidewire, said catheter comprising; a flexible tubular body having an inner lumen for receiving the irradiation source; a guidewire channel formed on said body for receiving the guidewire; a positioning means mounted on said body adjacent the intended position of the irradiation source, for positioning said body radially as desired within the blood vessel; and a closed distal end formed on said inner lumen to retain the irradiation source within said lumen; wherein said positioning means comprises: at least one balloon mounted on said body, said balloon being inflatable to radially extend at least one extremity of said balloon from said body to position said body as desired relative to the walls of the blood vessel; and an inflation lumen formed on said body, said inflation lumen being connected in flow communication with said balloon for providing inflation pressure to said balloon; wherein said at least one balloon comprises at least one substantially annular balloon surrounding said body.

Claim 17

A catheter as claimed in claim 12, further comprising a plurality of substantially annular balloons surrounding said body, said plurality of substantially annular balloons having extremities extending radially from said body by substantially equal distances.

Claim 18

A catheter as claimed in claim 13, wherein each of said substantially annular balloons comprises a plurality of lobes extending substantially equidistantly from said body.

Claim 21

A method as claimed in claim 15, further comprising the step of selectively positioning said distal end of said irradiation catheter at a desired radial position relative to the wall of said blood vessel.

Claim 22

A method as claimed in claim 16, wherein said step of selectively positioning said distal end of said irradiation catheter comprises the steps of: providing an expandable positioning means on said irradiation catheter, near said distal end of said catheter; and selectively expanding said positioning means to radially position said irradiation catheter as desired.

Claim 23

A method as claimed in claim 17, wherein: said expandable positioning means comprises a wire structure; and said step of expanding said positioning means comprises the step of expanding said wire structure.

Claim 24

A method as claimed in claim 17, wherein: said expandable positioning means comprises an inflatable structure; and said step of expanding said positioning means comprises the step of inflating said inflatable structure.

Claim 25

A method as claimed in claim 16, wherein said step of selectively positioning said distal end of said irradiation catheter comprises the steps of: introducing a bend into said guidewire near a distal end of said guidewire; rotating said guidewire to orient said bend toward a direction of desired deflection of said irradiation catheter; and partially withdrawing said guidewire from said guidewire channel while holding said irradiation catheter in place longitudinally, until said bend exerts sufficient force on said guidewire channel to cause said irradiation catheter to deflect in said desired direction by a desired amount.