US6071305A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Directional drug delivery stent and method of use
Assignee: Alza Corp
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Filing: 1997-11-24
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Granted: 2000-06-06
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Expires: 2017-11-24
Abstract
Abstract The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through directional delivery openings arranged on an outer surface of the elongated member. Another variation of the stent includes an osmotic engine assembly for controlling the delivery of the active agent from the reservoir. The drugs which may be applied by the directional delivery stent include, but are not limited to, steroids, anti-inflammatory agents, restenosis preventing drugs, anti-thrombotic drugs, and tissue growth regulating drugs. The invention also relates to a method of using the directional drug delivery stent.
Inventors
- 👤 James E. Brown
- 👤 Wouter E. Roorda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:27
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/88; A61F2/90; A61F2/91; A61F2/915; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0064; A61L33/06; A61L33/064; A61L33/066; A61L33/068; A61L33/08; A61F2002/91533; A61F2002/91541; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0058; A61F2250/0067; A61F2250/0068; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M2005/14513
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
78 words
A nonbiodegradable and expandable stent for directionally delivering an active agent, the stent comprising: a nonbiodegradable tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said tubular member having a recessed active agent receiving portion formed in said exterior surface, said recessed active agent receiving portion having a depth less than said tubular member thickness, said recessed active agent receiving portion containing at least one active agent.
Claim 2
Dependent Claim
78 words
A nonbiodegradable and expandable stent for directionally delivering an active agent, the stent comprising: a nonbiodegradable tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said tubular member having a recessed active agent receiving portion formed in said exterior surface, said recessed active agent receiving portion having a depth less than said tubular member thickness, said recessed active agent receiving portion containing at least one active agent.
Claim 3
Dependent Claim
22 words
The stent according to claim 1, wherein said recessed active agent receiving portion is a helical groove extending around said tubular member.
Claim 4
Dependent Claim
45 words
The stent according to claim 1, further comprising a plurality of slots extending through said tubular member thickness, said recessed active agent receiving portion including a plurality of spaced apart groove portions, adjacent ones of said groove portions being separated by one of said slots.
Claim 5
Dependent Claim
25 words
The stent according to claim 3, wherein when said stent is expanded said slots expand to increase a distance between adjacent ones of groove portions.
Claim 6
Dependent Claim
12 words
The stent according to claim 1, wherein said tubular member is cylindrical.
Claim 7
Dependent Claim
16 words
The stent according to claim 1, wherein said active agent is contained in a delivery matrix.
Claim 8
Dependent Claim
65 words
An expandable stent for directionally delivering an active agent, the stent comprising: a nonbiodegradable and tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said tubular member having a groove formed in said exterior surface, said groove having a depth less than said tubular member thickness, said groove containing at least one active agent.
Claim 9
Dependent Claim
65 words
An expandable stent for directionally delivering an active agent, the stent comprising: a nonbiodegradable and tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said tubular member having a groove formed in said exterior surface, said groove having a depth less than said tubular member thickness, said groove containing at least one active agent.
Claim 10
Dependent Claim
11 words
The stent according to claim 7, wherein said groove is helical.
Claim 11
Dependent Claim
41 words
The stent according to claim 7, further comprising a plurality of slots extending through said tubular member thickness, said groove including a plurality of spaced apart groove portions, adjacent ones of said groove portions being separated by one of said slots.
Claim 12
Dependent Claim
19 words
The stent according to claim 9, wherein said slots extend parallel with a longitudinal axis of said tubular member.
Claim 13
Dependent Claim
14 words
The stent according to claim 9, wherein said slots are formed with a laser.
Claim 14
Dependent Claim
16 words
The stent according to claim 7, wherein said active agent is contained in a delivery matrix.
Claim 15
Dependent Claim
12 words
The stent according to claim 7, wherein said tubular member is pipe-shaped.
Claim 16
Dependent Claim
26 words
The stent according to claim 7, wherein said active agent is one of steroids, anti-inflammatory agents, restenosis preventing drugs, anti-thrombotic drugs, and tissue growth regulating drugs.
Claim 17
Dependent Claim
14 words
The stent according to claim 7, wherein said groove is formed with a laser.
Claim 18
Dependent Claim
64 words
An expandable stent for directionally delivering an active agent, the stent comprising: a nonbiodegradable and tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said exterior surface of said tubular member having recessed means for receiving at least one active agent, said recessed means having a depth less than said tubular member thickness.
Claim 19
Dependent Claim
64 words
An expandable stent for directionally delivering an active agent, the stent comprising: a nonbiodegradable and tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said exterior surface of said tubular member having recessed means for receiving at least one active agent, said recessed means having a depth less than said tubular member thickness.
Claim 20
Dependent Claim
21 words
The stent according to claim 16, wherein said tubular member includes a plurality of openings passing through said tubular member thickness.
Claim 21
Dependent Claim
19 words
The stent according to claim 16, wherein said recessed means includes a helical groove formed in said exterior surface.
Claim 22
Dependent Claim
17 words
The stent according to claim 16, wherein said recessed means receives said at least one active agent.
Claim 23
Dependent Claim
16 words
The stent according to claim 19, wherein said active agent is contained in a delivery matrix.
Claim 24
Dependent Claim
19 words
The stent according to claim 19, wherein said recessed means includes a groove that is formed with a laser.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-06-06 | 2003-12-06 | 2004-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-06 | 2007-12-06 | 2008-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-06 | 2011-12-06 | 2012-06-06 | $7700.00 | Window Closed / Lapsed |