US5885647A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coating process
Assignee: Medicarb AB
•
Filing: 1995-12-05
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Granted: 1999-03-23
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Expires: 2015-12-05
Abstract
Abstract A process for coating of an intraocular lens to impart tissue compatibility thereto, comprising the steps: a) priming said lens using a solution of a polyamine; b) coating the lens treated in step a) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparain sulphate, and chondroitin sulphate to stabilize said polyamine by covalent and/or ionical cross-linking; c) coating the lens treated in step b) above with a solution of a polyamine; and d) coating the lens treated according to step c) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparain sulphate, and chondroitin sulphate in the presence of a cyanoborohydride to convert formed labile Schiff's bases to stable secondary amines.
Inventors
- 👤 Olle Larm
- 👤 Ibrahim Gouda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:43
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/08; A61L27/00; A61L27/28; A61L27/34; A61L33/0005; A61L33/0011; A61L33/0029; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
117 words
A process for the coating of an intraocular lens to impart tissue compatibility thereto, comprising the steps: a) priming said lens using a solution of a polyamine; b) coating the lens treated in step a) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparan sulphate, and chondroitin sulphate to stabilize said polyamine by covalent and/or ionical crosslinking; c) coating the lens treated in step b) above with a solution of a polyamine; and d) coating the lens treated according to step c) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparan sulphate, and chondroitin sulphate in the presence of a cyanoborohydride to convert formed labile Schiff's bases to stable secondary amines.
Claim 2
Dependent Claim
117 words
A process for the coating of an intraocular lens to impart tissue compatibility thereto, comprising the steps: a) priming said lens using a solution of a polyamine; b) coating the lens treated in step a) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparan sulphate, and chondroitin sulphate to stabilize said polyamine by covalent and/or ionical crosslinking; c) coating the lens treated in step b) above with a solution of a polyamine; and d) coating the lens treated according to step c) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparan sulphate, and chondroitin sulphate in the presence of a cyanoborohydride to convert formed labile Schiff's bases to stable secondary amines.
Claim 3
Dependent Claim
14 words
A process according to claim 1, wherein said polyamine is a polyethyleneimine or chitosan.
Claim 4
Dependent Claim
27 words
A process according to claim 1, wherein said polyamine is present in an aqueous solution in a concentration of from about 0.01 to about 0.1% by weight.
Claim 5
Dependent Claim
40 words
A process according to claim 1, wherein said periodate oxidized polysaccharide is present in an aqueous solution in a concentration of about 0.01 to about 0.1% by weight, the pH of said solution being from about 3 to about 5.
Claim 6
Dependent Claim
12 words
A process according to claim 1, wherein said cyanoborohydride is sodium cyanoborohydride.
Claim 7
Dependent Claim
32 words
A process according to claim 1, wherein step d) above is performed at an increased temperature, from about room temperature up to boiling, preferably from about 40° C. to about 75° C.
Claim 8
Dependent Claim
16 words
A process according to claim 1, wherein step b) is repeated between steps c) and d).
Claim 9
Dependent Claim
15 words
A process according to claim 7, wherein step a) is repeated after repeated step b).
Claim 10
Dependent Claim
29 words
A process according to claim 1, wherein the solution used in step a) also contains croton aldehyde at a basic pH, such as between about 8 and about 10.
Claim 11
Dependent Claim
17 words
A process according to claim 9, wherein the pH is maintained using a buffer or a base.
Claim 12
Dependent Claim
133 words
A process for the coating of an intraocular lens to impart tissue compatibility to said lens, comprising the steps: a) priming said lens using a solution of a polyamine and croton aldehyde; b) coating the lens treated according to step a) above with periodate-oxidized heparin or heparan sulphate to stabilize said polyamine; c) repeating step a) above on the lens treated according to step b) above; d) repeating step b) above on the lens treated in accordance with step c) above; e) treating the lens resulting from step d) above using a solution of a polyamine; and f) coating the lens treated in accordance with step e) above with a solution of periodate-oxidized heparin or heparan sulphate in the presence of a cyanoborohydride to convert formed labile Schiff's bases to stable secondary amines.
Claim 13
Dependent Claim
133 words
A process for the coating of an intraocular lens to impart tissue compatibility to said lens, comprising the steps: a) priming said lens using a solution of a polyamine and croton aldehyde; b) coating the lens treated according to step a) above with periodate-oxidized heparin or heparan sulphate to stabilize said polyamine; c) repeating step a) above on the lens treated according to step b) above; d) repeating step b) above on the lens treated in accordance with step c) above; e) treating the lens resulting from step d) above using a solution of a polyamine; and f) coating the lens treated in accordance with step e) above with a solution of periodate-oxidized heparin or heparan sulphate in the presence of a cyanoborohydride to convert formed labile Schiff's bases to stable secondary amines.
Claim 14
Dependent Claim
30 words
A process according to claim 1, wherein said intraocular lens, before priming in step a), is etched, such as with an oxidizing agent, for example ammonium peroxidisulphate in aqueous solution.
Claim 15
Dependent Claim
27 words
A process according to claim 2, wherein said polyamine is present in an aqueous solution in a concentration of from about 0.01 to about 0.1% by weight.
Claim 16
Dependent Claim
40 words
A process according to claim 2, wherein said periodate oxidized polysaccharide is present in an aqueous solution in a concentration of about 0.01 to about 0.1% by weight, the pH of said solution being from about 3 to about 5.
Claim 17
Dependent Claim
40 words
A process according to claim 3, wherein said periodate oxidized polysaccharide is present in an aqueous solution in a concentration of about 0.01 to about 0.1% by weight, the pH of said solution being from about 3 to about 5.
Claim 18
Dependent Claim
12 words
A process according to claim 2, wherein said cyanoborohydride is sodium cyanoborohydride.
Claim 19
Dependent Claim
31 words
A process according to claim 2, wherein step d) above is performed at an increased temperature, from about room temperature up to boiling, preferably from about 40° to about 75° C.
Claim 20
Dependent Claim
16 words
A process according to claim 2, wherein step b) is repeated between steps c) and d).
Claim 21
Dependent Claim
29 words
A process according to claim 2, wherein the solution used in step a) also contains croton aldehyde at a basic pH, such as between about 8 and about 10.
Claim 22
Dependent Claim
31 words
A process according to claim 11, wherein said intraocular lens, before priming in step a), is etched, such as with an oxidizing agent, for example ammonium peroxidisulphate in an aqueous solution.
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