US5069899A
Expired / Lapsed
US
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Anti-thrombogenic, anti-microbial compositions containing heparin
Assignee: Angiotech Biocoatings Corp
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Filing: 1989-11-02
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Granted: 1991-12-03
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Expires: 2009-11-02
Abstract
Abstract Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds not reacted with heparin and may also contain quaternary ammonium compound(s) reacted with antibiotics.
Inventors
- 👤 Richard J. Whitbourne
- 👤 Margaret A. Mangan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:55
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L27/00; A61L27/50; A61L27/54; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61L33/0023; A61L33/0029; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/208; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
50 words
An anti-thrombogenic composition comprising heparin reacted with a quaternary ammonium component mixed with a water-insoluble polymer, whereby said composition exhibits a degree of anti-thrombogenic characteristics for a relatively long period of time, and a resistance to removal or deactivation in human or animal body fluids when coated on a substrate.
Claim 2
Dependent Claim
50 words
An anti-thrombogenic composition comprising heparin reacted with a quaternary ammonium component mixed with a water-insoluble polymer, whereby said composition exhibits a degree of anti-thrombogenic characteristics for a relatively long period of time, and a resistance to removal or deactivation in human or animal body fluids when coated on a substrate.
Claim 3
Dependent Claim
35 words
The composition of claim 1 in which the quaternary ammonium is also reacted with an antibiotic which is capable of being gradually released to provide effective anti-microbial action over a relatively long period of time.
Claim 4
Dependent Claim
28 words
The composition of claim 2 in which the antibiotic agent is negatively charged and is selected from the group consisting of penicillin, ticarcillin, cefotoxin cephalosporins, oxacillin, and carbenicillin.
Claim 5
Dependent Claim
29 words
The composition of claim 1 in which the polymer is at least one selected from the group consisting of cellulose esters, polyurethane resins, acrylic polymers, condensation polymers, and polyisocyanates.
Claim 6
Dependent Claim
29 words
The composition of claim 1 in which the heparin-quaternary compound is present in a concentration of about 0.5% to 99.5% by weight with the balance comprising the water-insoluble polymer.
Claim 7
Dependent Claim
31 words
The composition of claim 1 which the quaternary ammonium compounds that are reacted by heparin include at least one of benzalkonium chloride, tridodecylmethylammonium chloride, cetylpyridinium chloride, benzyldimethylstearylammonium chloride, and benzylcetyldimethylammonium chloride.
Claim 8
Dependent Claim
82 words
An anti-thrombogenic composition comprising heparin reacted with a quaternary ammonium component mixed with a water-insoluble polymer which consists of at least one selected from the group consisting of water-insoluble cellulose polymers comprising nitrocellulose, cellulose acetate butyrate or cellulose acetate propionate; acrylic resin; polyurethane resin; polyisocyanate resin; and condensation polymers, whereby said composition exhibits a degree of anti-thrombogenic characteristics for a relatively long period of time, and a resistance to removal or deactivation in human or animal fluids when coated on a substrate.
Claim 9
Dependent Claim
82 words
An anti-thrombogenic composition comprising heparin reacted with a quaternary ammonium component mixed with a water-insoluble polymer which consists of at least one selected from the group consisting of water-insoluble cellulose polymers comprising nitrocellulose, cellulose acetate butyrate or cellulose acetate propionate; acrylic resin; polyurethane resin; polyisocyanate resin; and condensation polymers, whereby said composition exhibits a degree of anti-thrombogenic characteristics for a relatively long period of time, and a resistance to removal or deactivation in human or animal fluids when coated on a substrate.
Claim 10
Dependent Claim
14 words
The composition of claim 7 in which the heparin compound comprises heparin benzalkonium chloride.
Claim 11
Dependent Claim
35 words
The composition of claim 7 in which the quaternary ammonium compounds that are reacted with heparin include at least one selected from the group consisting of cetylpyridinium chloride, tridodecylmethylammonium chloride, benzyldimethylstearylammonium chloride, and benzylcetyldimethylammonium chloride.
Claim 12
Dependent Claim
35 words
The composition of claim 7 in which the quaternary ammonium is also reacted with an antibiotic which is capable of being gradually released to provide effective anti-microbial action over a relatively long period of time.
Claim 13
Dependent Claim
25 words
The composition of claim 7 in which the heparin-quaternary ammonium compound is present in a concentration of at least 0.5% by weight of the coating.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-02 | 1995-06-03 | 1995-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-02 | 1999-06-03 | 1999-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-02 | 2003-06-03 | 2003-12-03 | $7700.00 | Window Closed / Lapsed |